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Dr Vikram Sakaleshpur kumar 🇮🇳 Profile picture
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26 Nov, 12 tweets, 7 min read
B.1.1.529 seems to have gone from 0.1% to 50% in just a couple of weeks, when it took Delta several months to achieve that..!!

Brace up folks..!!
#NuVariant

Things are getting worrisome folks..!! Read and understand this thread..!!

Looks like a Double whammy folks..!! @DHFWKA @ICMRDELHI @MoHFW_INDIA
This new variant, B.1.1.529 seems to spread very quick! In less than 2 weeks now dominates all infections following a devastating Delta wave in South Africa (Blue new variant, now at 75% of last genomes and soon to reach 100%)
And it’s reached 🇮🇱….. as 🇮🇱 reports first case of new coronavirus variant B.1.1.529..!!
And this is what we know in 🇮🇱
@WHO to convene meeting at 12 p.m. Geneva time (6 a.m. ET) to assess new coronavirus #Variant #B11529 #NuVariant
@WHO @MoHFW_INDIA @ICMRDELHI @DHFWKA will lose their sleep over this #NuVariant ‼️
New (Nu) #Variant = very likely new (Nu) #pandemic
Karma for neglecting #Africa ‼️
All you need to know right now about the #NuVariant in #israel ..!! All the infected people were #vaccinated atleast twice with #Pfizer #vaccine ‼️For more 👇🏾

Hmm..!
some reassuring news...

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Dr Vikram Sakaleshpur kumar 🇮🇳 Profile picture
26 Nov
Such a well written editorial this in @Open_HeartBMJ Superb..!! openheart.bmj.com/content/8/2/e0…
a must read for everyone... #MedTwitter #Cardiology
interesting points a 🧵👇
Metabolic acidosis is a chronic condition that
many people in the Western world have but
do not realize it... It occurs when there is
retention of acid in the body, which leads to
a depletion in the bicarbonate stores of the
body. Ways to test for low-grade metabolic acidosis👇
what are the Four main mechanisms that compensate for chronic latent metabolic acidosis?
Read 8 tweets
Dr Vikram Sakaleshpur kumar 🇮🇳 Profile picture
26 Nov
pn.bmj.com/content/21/6/4… a superb article with many many learning points..#neurotwitter #MedTwitter #AcademicTwitter #scicomm
key points in the review article "Localization in focal epilepsy"👇
Cortical zones defined in presurgical evaluation
This is such a fantastic Summary of semiological signs by symptomatogenic zone on mesial and lateral structures. DLPFC, dorsolateral prefrontal cortex; SMA, supplementary motor area.
Read 6 tweets
Dr Vikram Sakaleshpur kumar 🇮🇳 Profile picture
25 Nov
#Covid outbreak in SDM Med college, Dharwad, #Karnataka after a student college festival.. many infected… @MoHFW_INDIA @DHFWKA @ICMRDELHI #news
Yesterday Day 1
URTI like symptoms !
Contact tracing done
Around 100 tests positive inc staff, students n other primary contacts !

All stable till now..!!
Yeah, the student festival was named ….

The Déjà vu…!!

Take care folks..!! @ProfSomashekhar @vipintukur @VincentRK @GKangInd @naveenthacker @iapindia @RajeevJayadevan
Read 5 tweets
Dr Vikram Sakaleshpur kumar 🇮🇳 Profile picture
7 Jun
Residual #SARS-CoV-2 🦠 ags detected in GI and liver tissues from 5 recovered pts with #COVID-19. gut.bmj.com/content/early/… @vipintukur @AskDrShashank @VirusesImmunity
#SARS-CoV-2 nucleocapsid protein (NP) was detected in the colon, appendix, ileum, haemorrhoid, liver, gall- bladder and lymph nodes from 5 pts who recovered from COVID-19, ranging from 9 to 180 days after testing -ve for SARS-CoV-2. #MedTwitter Image
Although resp transmission is responsible for most COVID-19 inf, there is ⬆️ evidence of COVID-19 causing GI & hepatic manifestations, as studies reported the presence positive SARS-CoV-2 RNA in anal swabs & stool samples, despite NP or sputum specimens testing -ve for the virus
Read 4 tweets
Dr Vikram Sakaleshpur kumar 🇮🇳 Profile picture
3 Jun
Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier.. @vipintukur @ProfSomashekhar @naveenthacker @iapindia @INDIANJOURNALO4 @VirusesImmunity @EditorIndPed @ICMRDELHI @MoHFW_INDIA @iiscbangalore Image
Weeks after #SARS-CoV-2 inf or exposure, some children develop a severe, life-threatening illness called Multisystem Inflammatory Syndrome in Children (#MIS-C). GI symptoms are common in MIS-C pts & severe hyperinflammatory response ensues with potential for ❤️ complications.
👉🏽As proof of concept, they treated a #MIS-C patient with #larazotide, a #zonulin antagonist, & monitored impact on antigenemia and clinical response.
👉🏽in MIS-C, prolonged + of SARS-CoV-2 in t GI tract ➡️ to release of zonulin, a biomarker of intestinal permeability,
Read 14 tweets
Dr Vikram Sakaleshpur kumar 🇮🇳 Profile picture
30 May
This gentle man is Sir William Osler.. He has frequently been described as the “Father of Modern Medicine” and one of the "greatest diagnosticians ever to wield a stethoscope". What did he hv to say about #India ? @sanjeevsanyal @vipintukur @naveenthacker @EricTopol @mvankerkhove Image
His fascination for #India, The land of #Vishnu had no bounds..!! At each & every intellectual commentary he mentions about his interest in the values #India was known for @ProfSomashekhar @iapindia @IndianMedicalAs @MoHFW_INDIA @VirusesImmunity Image
In one of his essays; “Of India, of "Vishnu-land," what can one say in a few minutes? To the Hindoos we owe a debt which we can at any rate acknowledge; and even in medicine, many of our traditions and practices may be traced to them”. @drharshvardhan @PMOIndia @BharadwajSpeaks Image
Read 11 tweets

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