Residual #SARS-CoV-2 🦠 ags detected in GI and liver tissues from 5 recovered pts with #COVID-19. gut.bmj.com/content/early/… @vipintukur @AskDrShashank @VirusesImmunity
#SARS-CoV-2 nucleocapsid protein (NP) was detected in the colon, appendix, ileum, haemorrhoid, liver, gall- bladder and lymph nodes from 5 pts who recovered from COVID-19, ranging from 9 to 180 days after testing -ve for SARS-CoV-2. #MedTwitter Image
Although resp transmission is responsible for most COVID-19 inf, there is ⬆️ evidence of COVID-19 causing GI & hepatic manifestations, as studies reported the presence positive SARS-CoV-2 RNA in anal swabs & stool samples, despite NP or sputum specimens testing -ve for the virus
It seems that a negative swab result might not necessarily indicate complete viral clearance from the body...!! @BagaiDr @ICMRDELHI @iiscbangalore

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More from @vikkypaedia

3 Jun
Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier.. @vipintukur @ProfSomashekhar @naveenthacker @iapindia @INDIANJOURNALO4 @VirusesImmunity @EditorIndPed @ICMRDELHI @MoHFW_INDIA @iiscbangalore Image
Weeks after #SARS-CoV-2 inf or exposure, some children develop a severe, life-threatening illness called Multisystem Inflammatory Syndrome in Children (#MIS-C). GI symptoms are common in MIS-C pts & severe hyperinflammatory response ensues with potential for ❤️ complications.
👉🏽As proof of concept, they treated a #MIS-C patient with #larazotide, a #zonulin antagonist, & monitored impact on antigenemia and clinical response.
👉🏽in MIS-C, prolonged + of SARS-CoV-2 in t GI tract ➡️ to release of zonulin, a biomarker of intestinal permeability,
Read 14 tweets
30 May
This gentle man is Sir William Osler.. He has frequently been described as the “Father of Modern Medicine” and one of the "greatest diagnosticians ever to wield a stethoscope". What did he hv to say about #India ? @sanjeevsanyal @vipintukur @naveenthacker @EricTopol @mvankerkhove Image
His fascination for #India, The land of #Vishnu had no bounds..!! At each & every intellectual commentary he mentions about his interest in the values #India was known for @ProfSomashekhar @iapindia @IndianMedicalAs @MoHFW_INDIA @VirusesImmunity Image
In one of his essays; “Of India, of "Vishnu-land," what can one say in a few minutes? To the Hindoos we owe a debt which we can at any rate acknowledge; and even in medicine, many of our traditions and practices may be traced to them”. @drharshvardhan @PMOIndia @BharadwajSpeaks Image
Read 11 tweets
29 May
#Mucormycosis and children...! What info do we have? After Covid-19, 16-Yr-Old Fights Mucormycosis, Pancreatitis, Stroke..!! ahmedabadmirror.com/after-covid-19… look at the confidence in this boy..!! Way to go boy..! @iapindia @naveenthacker @vipintukur @ProfSomashekhar @AskDrShashank
“He was operated on for it, his right-side palate and teeth had to be removed, and he is now on medication,” a 13 year old child..!! indiatoday.in/amp/india/stor… @ICMRDELHI @PedCritCareMed @INDIANJOURNALO4
The boy a 15 year old was discharged from the hospital earlier after successfully recovering from the #COVID19 disease in April. Later, he was diagnosed with Mucormycosis. No mention of any risk factors..!! @ARanganathan72 @PMOIndia. hindustantimes.com/india-news/guj…
Read 6 tweets
22 May
Inadvertent Pumping in too much of Zinc!could this also be contributing to this epidemic of #mucormycosis #blackfungus in association with other risk factors...!? @MoHFW_INDIA @ProfSomashekhar @BagaiDr @iiscbangalore @ShamikaRavi @ICMRDELHI @ARanganathan72
ncbi.nlm.nih.gov/pmc/articles/P…
ipen.br/biblioteca/200… is this coincidental...!! Image
ncbi.nlm.nih.gov/pmc/articles/P… we seem to be pushing the already susceptible by feeding the #BlackFungus with more and more #zinc by negating the “nutritional immunity”... ImageImage
Read 7 tweets
19 May
#Covid19 is probably the greatest debunker in #medicine we have seen...

Read this ... 👇🏾
🧵 *** The researchers found no evidence of a difference in response in biochemical markers of #inflammation between patients with #MIS-C/PIMS-TS who were treated with #IVIG, #steroids, or #biologics, compared with those who were not.
*** Despite a lack of evidence, 🇬🇧 and 🇺🇸 treatment guidelines for MIS-C/PIMS-TS have become very similar.

*** By the end of the study period, most patients had received immunomodulation.
#AcademicChatter #AcademicTwitter #MedTwitter #foamed #MedStudentTwitter #LongCovidKids
Read 5 tweets

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