🚨New study: We tested if antibodies from previously infected and vaccinated individuals can neutralize ancestral #SARSCoV2, #beta, #delta, and #omicron variants.
(1/7) Short thread on what we found.
biorxiv.org/content/10.110…
#COVID19 @VIDO #LZCI
(1/7) Short thread on what we found.
biorxiv.org/content/10.110…
#COVID19 @VIDO #LZCI
(2/7) We isolated variants of concern (VOCs) from clinical specimen and sequenced them to confirm their whole genome sequences. We used these viruses to test antibody levels in serum from infected and vaccinated individuals. 
(3/7) Important – infection with ancestral SARS-CoV-2 or delta variant alone does not induce high levels of neutralizing antibodies against omicron. But..
(4/7) the good thing is that if you receive two doses of the vaccine, your antibody levels will be much higher against omicron. So go get those shots if you are eligible! #CovidVaccine
(5/7) finally, three doses of the Pfizer or Moderna vaccine induces detectable levels of neutralizing antibodies against #omicron in serum samples from long-term care residents, but still lower than levels seen against ancestral virus. So, what does this all mean?
(6/7) It is critical that we determine correlates of protection against severe #COVID19 to inform future vaccine booster strategies. New variants will likely emerge, and we need a coordinated system in place to rapidly assess threats from these variants.
(7/7) For now, go get your #vaccines and hang in there!
Grateful for help from trainees, staff and colleagues @VIDOInterVac @Sunnybrook @UofT @DalhousieU @usask @SinaiHealth. Support from @CIHR_IRSC @CoVaRR_Net @VIDOInterVac @InnovationCA and others.
Grateful for help from trainees, staff and colleagues @VIDOInterVac @Sunnybrook @UofT @DalhousieU @usask @SinaiHealth. Support from @CIHR_IRSC @CoVaRR_Net @VIDOInterVac @InnovationCA and others.
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