Mia Malan Profile picture
Jan 18 6 tweets 4 min read
JUST IN: [Thread] 1/6
1. @CEPIvaccines and Institute Pasteur de Dakar (IPD) have signed an MOU to fill and finish up to 300 million doses of #COVID19 jabs per year
2. Production will start in the 3rd quarter of 2022
2/6 What is "fill + finish?"
1. It's when a company handles the end part of the production of a meds
2. In the case of jabs a company imports the drug (active) substance/key ingredient, mixes it with an inactive substance, puts it in vials (pouches in IPD's case) + packages it
3/6
1. IPD will use a different method to fill + finish #COVID19 jabs
2. It won't put the jabs in glass vials, rather in plastic pouches (like a drip bag) that can hold 200 doses of vaccine per pouch
3. The pouch method = more suitable for poorer countries. Why? (next tweet)
4/6
1. The pouches are lighter and smaller than glass vials
2. They're therefore easier to transport/store and it's cheaper to maintain a cold chain
3. It's quick and easy to administer jabs from the pouches
4. @CEPIvaccines + MedInstill/INTACT Solutions = developed the tech
5/6 How far are things?
1. The IPD manufacturing facility is in an advanced stage of being built
2. IPD is on track to start to fill and finish #COVID19 jabs between July and September 2022
6/6 What other jabs does IPD make?
1. Yellow fever shots which are WHO prequalified (it means the WHO has evaluated the quality + approved it as of a good enough standard 4 donors + aid agencies to buy + distribute)
2. IPD has also signed an MOU with BioNTech 2 make
#mRNA jabs

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More from @miamalan

Jan 14
[Thread] 1. What's happening with SA #Omicron hospital + death data?

Waasila Jassat, @nicd_sa:
"Decoupling" between cases, hospitalisations/deaths = continue.

Black: new #COVID19 cases
Grey: hospitalisations
Red: deaths

Cases higher than Wave 1-3, admissions/deaths = lower
2. #Omicron started in Gauteng + spread 2 other provinces within a week. With previous waves the spread 2 other parts of the country took much longer. So with #Omicron the peaks of provinces' hospitalisations/deaths = much closer to each other.
3. #Omicron hospital admissions in SA peaked at about 60% of the #Delta wave and deaths at about 14-15%
Read 11 tweets
Jan 14
JUST IN [Thread] 1. @SAHPRA1 is reviewing 6 #COVID19 #vaccine applications for emergency use authorisation (called Section 21 approval), including new applications for #Sputnik Lite (1 shot of the 2-shot #Sputnik V jab) and #Novavax.
2. Four of the 6 #COVID19 #vaccine applications are for 2 of the same jabs. So different companies applied 4 approval 4 the same vaccines:
1. #Sputnik (Dr Reddy's Labs, Lamar International)
2. #Sinopharm (MC Pharma, Lamar International; Lamar also applied for Sputnik Lite)
3. On 18 Oct @SAHPRA1 rejected Lamar International's application 4 #Sputnik because of concerns that it might increase HIV negative people's risk of #HIV infection. The application remains open. Lamar needs to submit data to prove the jab is safe.

Read 10 tweets
Jan 14
[Thread] 1. The LATEST on #Omicron in SA

@Dr_Groome of @nicd_sa:
1. Almost 99% of all new #COVID19 cases in SA now = #Omicron (Omicron = red on table, see Nov/Dec)
2. Extremely low proportions of other variants are currently detected through sequencing
2. @Dr_Groome:
1. SA reached its #Omicron peak on 15 Dec (22,588 new #COVID19 cases on that day)
2. Reported cases = only +/- 10% of the actual cases
3. There's been a small increase in new cases over Xmas, but we have seen persistent decreases in terms of 7 day moving averages
3. @Dr_Groome:
1. Previous waves were longer and waves started and ended a few weeks apart in different provinces. With #Omicron the wave is much steeper and provinces followed each other much quicker
2. Gauteng (where SA's Omicron wave started) has exited its 4th (Omicron) wave
Read 10 tweets
Jan 14
[Thread] 1. From TONIGHT (Fri), 8pm, adult #COVID19 hospitalisation data in SA will be available on @HealthZA's dashboard.

Milani Wolmarans, @HealthZA, #EVDS:
The data will be categorised into 3 types of patients:
1. Fully vaccinated
2. Partially vaccinated
3. Unvaccinated
2. What's happening so far?
Of 7,826 adults in hospital because of #COVID19:
- 5,731 (73%) = unvaccinated
- 321 (4%) = partially vaccinated (this = lower than fully vaccinated as there are far fewer partially than fully vaxxed people in total)
- 1,774 (22.6%) = fully vaxxed
3. What % of adults (18+) have been fully + partially vaccinated?

1. Fully vaccinated: 40.14% (if 2020 Stats SA population estimates = used)
2. Partially vaccinated (1 shot of #Pfizer only): 7.7% (12,367,221 [1st shots] - 9,289,091 [2nd shots] = 3,078,130 [1st shot only])
Read 10 tweets
Jan 14
[Thread] #JoePhaahla:
1. WC currently has the highest nr of new #COVID19 cases, followed by KZN
2. Gauteng has officially excited its 4th (#Omicron) wave
3. All other 8 provinces have reached their Omicron peaks and new cases on a decline
2. #JoePhaahla:
1. Although there is a decline in new #COVID19 cases in all provinces, the decline is slower than what the increase
2. That means the Omicron wave is declining at a slower pace than what it had increased
3. #JoePhaahla:
1. There has been a 5% reduction in reported deaths in SA over the past 7 days
2. There has been a 27% decline in new #COVID19 cases over the past 7 days
Read 4 tweets
Jan 10
JUST IN [Thread] 1. Early findings from 2 SA studies suggest #Omicron has a much higher rate of asymptomatic "carriage" (#COVID19 without symptoms) than previous variants and this is likely an important reason why the variant spreads so fast.
Preprint: bit.ly/3q8NykS
2. Which studies are findings based on?
1. Ubuntu: A sub-Saharan #Africa study that measures the effectiveness of #Moderna's #COVID19 jab in #HIV+ people (all initial sites in SA)
2. A sub-study of #Sisonke, conducted among SA #HealthWorkers, that measures #JnJ's effectiveness
3. Neither of the studies = designed 2 look @ asymptomatic infections specifically, rather 2 measure breakthrough infections, immunogenicity + effectiveness of jabs in HIV+ and other groups, but they do give useful info on how #Omicron's spread differs from other variants.
Read 9 tweets

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