Thread by @WesElyMD

1/🧵 #WISDOM of Wine, Coffee & Chocolate. 🍷 🍫 ☕️
 
Millions love morning coffee or curling up w DARK chocolate & wine
 
What’s the #SCIENCE?

All 3 in moderation are safe…
 
This thread will focus on WINE! Let’s explore actual SCIENCE…

2/ This infographic shows the putative benefits – weight & BP control, diabetes & stroke prevention. But what do actual data say about this?
 
bit.ly/3LqvKug

3/ Wine has antioxidants and flavonoids that might reduce cardiac disease.
bit.ly/3LtmGEG
 
Resveratrol from grapes inhibits initiation, promotion, and progression of cancer.
bit.ly/34RZpeK

4/ A massive study in ~25,000 patients & >257,000 person-years (Copenhagen Heart) tracked beer, wine & spirits; smoking, physical activity, education, BMI.
 
All-cause mortality, cardiac, & cancer related deaths ⬇️ w moderate use of 1 to 2 drinks/day.
 
bit.ly/3LuKYyb

5/ The famous Framingham Heart Study also showed a reduction in heart failure with moderate drinking of wine up to ~1.5 drinks/day.
 
bit.ly/3BjGfuM

6/ 38,000 male health care professionals free of heart dz were studied over 12 yrs & 1,418 heart attacks. The type of beverage didn’t matter – beer, white, red, or liquor. A 12.5g ⬆️ in daily alcohol consumption reduced heart attacks by 22% over 4 yrs.

bit.ly/3JqXJI7

7/ In an Extension of the Physicians Health Study of 89,000 men (N=14,125 with a  Hx of HTN), it was shown that as compared to NON-drinkers, monthly, weekly & daily alcohol use cut risk of cardiovascular death by up to 50%.
 
bit.ly/3HMkGW1

8/ A study of the psychological effects of drinking showed that beer drinkers had lower IQs, more neuroticism and psychoticism, higher levels of lying, and more overt abuse.
 
bit.ly/3BiCaab

9/ The same study showed that WINE drinkers had higher parental education, socioeconomic status, less alcohol abuse, and optimal functioning on personality tests, psychiatric symptoms, and health-related behavior.

bit.ly/3BiCaab

10/ The #nurse health study of N=12,480 nurses showed that 1 drink per day of beer or wine had 25% ⬇️ cognitive decline (note risk is lower - on LEFT👇) and there was no increase even up to 2 drinks per day. This is very encouraging for brain health!
 
bit.ly/3uLaQzO

11/ Light to moderate 🍺 🍷
(1.5 drinks/day) reduced risk of a Stroke by 25%. But increased drinking up to 3 to 4 drinks per day made risk go UP by 75%.
 
J-WAVE: it’s another example of the J wave of concern. Moderation is good. Excess is bad.

bit.ly/3Bl9woS

12/ Should diabetics drink alcohol in moderation?

A 2-year study of 224 stable Diabetics randomized to 150 ml of water, white wine, or red wine. All on Mediterranean diet.

Wine was superior to water in reducing lipids & controlling sugars in diabetics.
 
bit.ly/3HOdLeO

13/ CONCLUSIONS:
Wine or combinations of alcohol in these studies were STRONGLY associated w reduced morbidity & mortality from all-causes, heart, cancer, and stroke risk.
 
The J-shaped curve has been consistently proven.

That means =
Everything in moderation = Happier life!

14/fin
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Arch Int Med 2001;161:1844-8
Arch Int Med 2003;163:1189-3
Ann Int Med 2002;136:181-91
NEJM 2003;348:109-8
NEJM 2003;348:163-4
JAMA 2003;289:579-88
Arch Int Med 2004;164:623-8
NEJM 2005;352:245-53
Ann Int Med 2015;163:569-79