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David A. Sinclair AO PhD Profile picture
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Mar 19 • 5 tweets • 3 min read
A landmark identical twin study indicates how a child is raised (e.g. type & amount of food, lack of exercise) influences their rate of aging & how healthy they will be for the rest of their life. How often do we hear, "Oh, they'll grow out of it"? tinyurl.com/4kemv9mb
A child's lifestyle appears to influence a variety of human conditions, such as obesity, type 2 diabetes, cardiovascular diseases, #cancer & #mentalillness
Non-genetic associations with DNA methylation patterns (epigenetic associations) #aging #Health
Genetic associations with DNA methylation patterns
Evidence that lifestyle influences the rate of aging. These twins are genetically identical but one didn't live a healthy lifestyle #life #fitness

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More from @davidasinclair

David A. Sinclair AO PhD Profile picture
Mar 16
New paper: Scientist @MayoClinic report that humans who’ve ingested dasatinib + quercetin to destroy senescent cells have higher levels of the suspected longevity protein called Klotho, which in mice increases lifespan by 30%
Clotho is the one of the Three Fates in Greek mythology. Seen on the left, she spins the thread of human life, including deciding when a person is born🤰Lachesis draws out life and Atropos cuts it 💀
newsnetwork.mayoclinic.org/discussion/sen…
Read 5 tweets
David A. Sinclair AO PhD Profile picture
Mar 16
What do lentils have to do with #Covid_19? Lectins are ancient proteins that evolved before antibodies to inactivate invading organisms. Human mannose-binding lectin has been found to inactivate #SARSCoV2. So have lectins in plants, such as one made by the common lentil 🌱1/n
Mannose-binding protein, MBL, is a member of the collectin family, and it has a carbohydrate recognition domain and a collagen-like domain @NatImmunol 2/n nature.com/articles/s4159…
The first study of lectins began 134 years ago by Peter Stillmark who found that the seed extracts of the Castor bean can cause red blood cells stick together. The lectin was named Ricin. 3/n ncbi.nlm.nih.gov/pmc/articles/P…
Read 5 tweets
David A. Sinclair AO PhD Profile picture
Feb 11
Caloric restriction (CR) may extend lifespan. People who did 14% CR for 2 yrs had gene expression changes in fat incl. NAMPT, which makes NAD, and Pla2g7. In mice, deletion of Pla2g7 reduced inflammatn & kept the immune system young, pointing to new drugs tinyurl.com/4nd8tyx6
The gene expression changes were similar to effects of bariatric surgery and exercise and included nutrient sensing, inflammation and longevity
The data from this human study are also relevant regarding controversies emerging from animal studies that questioned CR’s effects on health and inflammation
Read 5 tweets
David A. Sinclair AO PhD Profile picture
Feb 3
Turning up the fruit fly Sirt6 gene slows 🪰 aging and extends lifespan, just as in 🐭 and possibly 👩🏻, apparently by mimicking fasting and slowing protein production
🪰 pnas.org/content/119/5/…
🐁 pubmed.ncbi.nlm.nih.gov/34050173/
👩🏻 tinyurl.com/ytb63s7t
The above is a mortality curve, with % of the fly population still alive each day
Companies are in a race to make therapies that a turn up Sirt6 to treat cancer, metabolic diseases and inflammation. Might make an announcement soon 🙊
longevity.technology/gene-therapy-u…
Read 5 tweets
David A. Sinclair AO PhD Profile picture
Jan 22
Ignore the clickbait title - here’s a well researched article about real companies working on age reversal to treat real diseases 1/n @NatureBiotech @sciam tinyurl.com/yckpbmb4
Space is red 🔥. Companies highlighted: 2/n
“Multiple companies have sprung up to build on these pioneering studies: Sebastiano co-founded Turn Bio, Sinclair set up Life Biosciences, & Izpisúa Belmonte has joined Altos Labs.” 3/n
Read 4 tweets
David A. Sinclair AO PhD Profile picture
Jan 15
Risk of multiple sclerosis increases 32-fold after infection with Epstein-Barr virus (which causes Mono). These findings cannot be explained by any other risk factor and suggest EBV as the leading cause of MS 1/n
Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the herpes virus family. It is one of the most common human viruses @CDCgov 2/n
Most people get infected with EBV at some point in their lives. EBV spreads most commonly through bodily fluids, primarily saliva 3/n
Read 6 tweets

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