7⃣+ months of Norovirus🦠positivity➕
in this ⚠️Primary Immunodeficiency patient
▪️ Rx-resistant
🧬-> intra-host evolution led to a unique norovirus strain
bit.ly/3RbH53d #bioinformatics #openscience #scicomm #itrtg #raredisease #genomics #immunology Image
Very much in line with what has been seen
in some persistent🦠Sars-Cov-2 infections in immunocompromised hosts.
▪️ viral-clearance failure
▪️ within-host viral evolution/mutations
*the report gives no indication on the fate of the patient.
⚠️Immunocompromised patients ⚠️as atypical
"outliers" with almost every🦠infectious pathogen (circa 2017).
❗️ PLEASE doctors - keep a good 👁️eye on those
with compromised immune-systems
jiac-j.com/article/S1341-… #openscience #scicomm #meded Image
...and sadly, full-circle return
to🦠Sars-Cov-2:
114 days of➕positivity in this immuno/compromised/supressed patient
Outcome: Fatal
sciencedirect.com/science/articl… #openscience #womeninstem #scicomm #COVID19 Image

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Yoni Maisel

Yoni Maisel Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Primary_Immune

Aug 28
🦠 ->🧠
I'm seeing a noticeable ⬆️uptick
in these disturbing reports:
#COVID19-associated psychosis in young patients
with *NO* prior history of mental-illness
publications.aap.org/pediatrics/art… #serverless #womeninstem #itrtg #scicomm #openscience #iot #neuroscience Image
He expressed that "the information system in his brain had been deleted,"
and the government was “coming for him.”
He experienced auditory hallucinations;
“everyone around the world is saying not to let the
doctors do the test” and believed the tests would kill him."
Sars-Cov-2 🦠and ➡️ the 🧠brain
(a partial list of pathology) :
➡️ encephalitis, encephalopathy, seizures, Parkinsonism, altered consciousness, stroke, ataxia, myclonia, hallucinations, psychosis, brain hemorrhaging, vasculitis, coma...
Not just an illness of the 🫁 lungs.
Read 4 tweets
Aug 27
Relapsed/persistent
🦠Sars-Cov-2 escaped detection in these
2⚠️immunocompromised patients
...good thing these inquistive teams dug "deeper."
sciencedirect.com/science/articl… #bioinformatics #openscience #itrtg #COVID19 #iot #scicomm #immunology #virology Image
"2 cases occult SarsCov2 in immunocompromised hosts: Dx originally not suspected due to repeat negative SARS-CoV-2 from NP specimens
isolation of viable SARS-CoV-2 virus + nucleocapsid + spike-protein antigen in lung tissue on immunohistochemistry 3-months from primary infection"
"suggests ongoing 🦠viral persistence and replication as a driver of the lung parenchymal changes,
which resolved after antiviral treatment."
Both patients survived:
discharged on days 80 and 100 respectively.
Read 4 tweets
Aug 2
⚠️Beware🦠Omicron:
It doesn't give *⃣ 2 shits *⃣ if you've been infected
with prior variants
...and get💉vaxxed!
wwwnc.cdc.gov/eid/article/28… #bioinformatics #serverless #openscience #snrtg #scicomm #immunology
*⃣ Sorry - I posted the link to the graph
This is the link to the article itself:
wwwnc.cdc.gov/eid/article/28…
The best protection against infection
and/or reinfection with Omicron🦠:
Vaxx/boost💉➕ masking 😷
Read 6 tweets
Jul 16
This will likely have incalculable
repercussions in lives lost.
reut.rs/3ze7sj3 #globalhealth #snrtg #openscience #scicomm #medtwitter #VaccinesSaveLives Image
Expect a likely resurgence of vaccine-preventble pediatric infectious, communicable diseases - according to this study...measles, rubella, mumps, pertussis, polio, rotavirus...
Likely causes of this backslide in childhood vaccination:
▪️ global vaccine-"fatigue"
▪️ hyper-focused attention on one disease (🦠
SarsCov2), while virtually ignoring all others.
Read 4 tweets
Jul 15
Brand 🆕 insight into the mechanism of
anti-interferon (IFN)–γ autoantibodies
- implications for 🧬Inborn Errors of Immunity⚠️
and 🦠SarsCov2
#bioinformatics #openscience #scicomm #immunology #genomics #raredisease
These auto-ABs are linked 🦠to:
1⃣ Primary Immunodeficiencies / "IEIs": susceptibility to certain infections
2⃣ Susceptibility to severe and fatal COVID-19
The anti-interferon (IFN)–γ autoantibody
➡️🦠#COVID19 connection
bit.ly/3yGDbaY #bioinformatics #openscience #scicomm
Read 4 tweets
Jul 12
A large🆕study confirms
the⚠️danger of 🦠SarsCov2
to the #immunocompromised
Take precautions to protect yourself
cdc.gov/mmwr/volumes/7… #WomenInSTEM #openscience #itrtg #scicomm #medtwitter #immunology #raredisease
▪️ 💉vaxx ➕boost💉
▪️😷 mask on and up
▪️📏 practice strategic social-distancing
If you are immunodeficient or immunocompromised,
(👤LIKE ME) ... these 3⃣ things could well save your life.
A news article which accompanies the above research:
"Study highlights need to prioritize
immunocompromised COVID patients"
news-medical.net/news/20220710/… #WomenInSTEM #openscience #scicomm
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(