Shira and I (Rebecca) live on a haunting night walk,
to honor those killed on 7 October 2023,
and to pray for our hostages.
🇮🇱 🕯️🎗️58🎗️
~filling in for Yoni who remains away. The 7th of October Museum on Hazaytim Street here in Haifa, Israel.

Immunodeficient life:
I broke a tooth 🦷 while eating a sandwich 🍞with cherry 🍒jelly because a pit in one of the cherries was missed and not removed.
It is now badly 🦠infected
- I am on 3⃣ 💊antibiotics with high 🌡️ fever.
Tomorrow 🏥I have to have the abcess🩸 drained. Antibiotics will be changed from oral to I.v. if the fever fails to resolve by tomorrow.
I'm told hospitalization is a real possibility.
From a pit, in a cherry, in jelly.

Pediatric🧬Inborn Error of Immunity⚠️
*⃣ "mutations in RIPK1 are
a 🆕monogenic form of IBD"
Great work by Israeli 🇮🇱, Palestinian 🇵🇸 & US 🇺🇸 researchers
frontiersin.org/articles/10.33… #bioinformatics #datascience #iot #snrtg #openscience #raredisease #gastro #genomics #immunology Atypical, severe, immuno- phenotype in young patient(s)' ❓
➡️Think🤔 genetic
⬇️
Sequence her/his🧬DNA.
⬇️
Seek 🔎clues in the genome!

A long battle for survival in a
Sars-Cov-2🦠➕Aspergillosis🦠co-infected
⚠️immunocompromised⚠️patient
(post- stem-cell transplant for leukemia)
ncbi.nlm.nih.gov/pmc/articles/P… #bioinformatics #itrtg #datascience #serverless #openscience #iot #raredisease #immunology #COVIDIsAirborne These scenarios are unique to the
⚠️immunocompromised & immunodeficient⚠️.
If you are as such, please do EVERYTHING in your
power to avoid 🦠 Sars-Cov-2 infection:
💉vaxx ➕😷 mask ➕strategic social-📏-distancing.

🆕: COVID-19🦠vaxx-💉-response in a cohort of
#immunocompromised children
organ-transplant; stem-cell transplant; rheum, +
- 2 vs 3 dose study
go.nature.com/3hERBn3 #serverless #openscience #scicomm #itrtg #iot #raredisease #datascience #immunology A majority of the children mounted effective humoral repsonse following 2 doses; increase to near 100% following.
Caveat: these study authors recommend a 3-dose regimen in immunocompromised pediatric patients.

▪️ High-profile man on Twitter tweets an article he had no part in writing - gets 100s of RTs & likes, and "thanks."
▪️ Woman who authored the paper after year(s) of hard work, tweets it and gets NO RTs, 1 like, and no "thanks."
F-CK that.
#womeninstem #academictwitter #scicomm Misogyny and sexism are alive and well.

🆕: Severe, atypical, post-🦠- #COVID19
neurological🧠 sequelae
💉responsive to IVIg
…mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md… #serverless #womeninstem #openscience #scicomm #snrtg #LongCovid #neurology #immunology 🙏KUDOS and respect to this brave gentleman for consenting to the publication of this video and giving a glimpse into one of the many ways in which 🦠Sars-Cov-2 is affecting the🧠brains of those it infects.
#openscience #scicomm

🆕: ⚠️Not so mild 🦠#COVID19
in this immunosuppressed patient
- development of atypical, severe, acute 🧠 meningitis
ijidonline.com/article/S1201-… #bioinformatics #womeninstem #openscience #scicomm #snrtg #genomics #immunology This patient could not have wound up in better hands:
National Institute of Infectious Diseases
“Lazzaro Spallanzani” IRCCS- Rome, 🇮🇹 Italy
👍 great job treating this patient,
sequencing and monitoring🧬the 🦠strain,
...and saving her life
#openscience #scicomm

🦠 ->🧠
I'm seeing a noticeable ⬆️uptick
in these disturbing reports:
#COVID19-associated psychosis in young patients
with *NO* prior history of mental-illness
publications.aap.org/pediatrics/art… #serverless #womeninstem #itrtg #scicomm #openscience #iot #neuroscience He expressed that "the information system in his brain had been deleted,"
and the government was “coming for him.”
He experienced auditory hallucinations;
“everyone around the world is saying not to let the
doctors do the test” and believed the tests would kill him."

Relapsed/persistent
🦠Sars-Cov-2 escaped detection in these
2⚠️immunocompromised patients
...good thing these inquistive teams dug "deeper."
sciencedirect.com/science/articl… #bioinformatics #openscience #itrtg #COVID19 #iot #scicomm #immunology #virology "2 cases occult SarsCov2 in immunocompromised hosts: Dx originally not suspected due to repeat negative SARS-CoV-2 from NP specimens
isolation of viable SARS-CoV-2 virus + nucleocapsid + spike-protein antigen in lung tissue on immunohistochemistry 3-months from primary infection"

7⃣+ months of Norovirus🦠positivity➕
in this ⚠️Primary Immunodeficiency patient
▪️ Rx-resistant
🧬-> intra-host evolution led to a unique norovirus strain
bit.ly/3RbH53d #bioinformatics #openscience #scicomm #itrtg #raredisease #genomics #immunology Very much in line with what has been seen
in some persistent🦠Sars-Cov-2 infections in immunocompromised hosts.
▪️ viral-clearance failure
▪️ within-host viral evolution/mutations
*the report gives no indication on the fate of the patient.

⚠️Beware🦠Omicron:
It doesn't give *⃣ 2 shits *⃣ if you've been infected
with prior variants
...and get💉vaxxed!
wwwnc.cdc.gov/eid/article/28… #bioinformatics #serverless #openscience #snrtg #scicomm #immunology *⃣ Sorry - I posted the link to the graph
This is the link to the article itself:
wwwnc.cdc.gov/eid/article/28…

This will likely have incalculable
repercussions in lives lost.
reut.rs/3ze7sj3 #globalhealth #snrtg #openscience #scicomm #medtwitter #VaccinesSaveLives Expect a likely resurgence of vaccine-preventble pediatric infectious, communicable diseases - according to this study...measles, rubella, mumps, pertussis, polio, rotavirus...

Brand 🆕 insight into the mechanism of
anti-interferon (IFN)–γ autoantibodies
- implications for 🧬Inborn Errors of Immunity⚠️
and 🦠SarsCov2

https://twitter.com/JExpMed/status/1547621961106198529?ref_src=twsrc%5Etfw

#bioinformatics #openscience #scicomm #immunology #genomics #raredisease These auto-ABs are linked 🦠to:
1⃣ Primary Immunodeficiencies / "IEIs": susceptibility to certain infections
2⃣ Susceptibility to severe and fatal COVID-19

A large🆕study confirms
the⚠️danger of 🦠SarsCov2
to the #immunocompromised
Take precautions to protect yourself
cdc.gov/mmwr/volumes/7… #WomenInSTEM #openscience #itrtg #scicomm #medtwitter #immunology #raredisease ▪️ 💉vaxx ➕boost💉
▪️😷 mask on and up
▪️📏 practice strategic social-distancing
If you are immunodeficient or immunocompromised,
(👤LIKE ME) ... these 3⃣ things could well save your life.

🦠This is dreaded
"Marburg Virus"🔬 (Video: PLOS)
- case-fatality-rate up to 9⃣0⃣%
🩸hemorrhaging from all orifices leads to death
*⃣ 2 patients in Ghana have just tested positive aljazeera.com/news/2022/7/8/… #scicomm #openscience #medtwitter #snrtg #virology Marburg Virus is classified as a hemorrhagic fever virus. It is closely related to Ebola Virus.
Some scary viruses out there beyond Sars-Cov-2.

Quite remarkable results in this
5 year-old suffering severe post-effects of
a rare form of autoimmune 🧠encephalitis
journals.sagepub.com/doi/10.1177/09… #snrtg #medtwitter #openscience #scicomm #neurology #immunology #stemcell "The patient was in a vegetative state when she was first admitted to hospital and received cell therapy as a last resort."
...she is now ready to attend school.

🦠9⃣-MONTH Sars-Cov-2 infection in an
immunocompromised patient
⚠️ with more than 20 🧬viral mutations
academic.oup.com/cid/advance-ar… #bioinformatics #openscience #scicomm #snrtg #immunology #genomics Getting 💉vaccinated💉: 1⃣ protects the immunocompromised from SarsCov2, and 2⃣: protects ALL OF US from the emergence of new🦠variants🧬

⏰5:38 AM🌄☕️ Good morning.
In my country 🇮🇱,
the work-week begins on Sunday. ...and for most, it ends on Thursday.

. 🧬Exciting stuff! 🧬
Hope of a genetic-"fix" for youngsters with a rare blood disorder
newscientist.com/article/232451… #bioinformatics #snrtg #scicomm #openscience #technology #biotech #genomics #raredisease The clinical trial results which prompted extending CRISPR treatment to kids for
🧬 Sickle-cell and Beta-Thalassemia🩸
bit.ly/3n4MwUO #openscience #scicomm

My country 🇮🇱:
in new full-blown #COVID19 🦠wave
⚠️New cases up 7⃣0⃣0⃣% in past 3 weeks
hospitalizations up 90%; positivity rate: 39%
datadashboard.health.gov.il/COVID-19/gener… #openscience #scicomm #snrtg 🇮🇱 COVID-19🦠:
Just In ⚠️
Our Health Ministry has instructed
Israeli hospitals to re-open shuttered COVID wards.
#CovidIsNotOver