Relapsed/persistent
🦠Sars-Cov-2 escaped detection in these
2⚠️immunocompromised patients
...good thing these inquistive teams dug "deeper."
sciencedirect.com/science/articl… #bioinformatics #openscience #itrtg #COVID19 #iot #scicomm #immunology #virology
"2 cases occult SarsCov2 in immunocompromised hosts: Dx originally not suspected due to repeat negative SARS-CoV-2 from NP specimens
isolation of viable SARS-CoV-2 virus + nucleocapsid + spike-protein antigen in lung tissue on immunohistochemistry 3-months from primary infection"
"suggests ongoing 🦠viral persistence and replication as a driver of the lung parenchymal changes,
which resolved after antiviral treatment."
Both patients survived:
discharged on days 80 and 100 respectively.
"...negative nasopharyngeal samples *⃣ do not *⃣ rule out 🦠SARS-CoV-2 persistence, and invasive sampling must be considered...."
(the authors' very sensible words)

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More from @Primary_Immune

Aug 28
🦠 ->🧠
I'm seeing a noticeable ⬆️uptick
in these disturbing reports:
#COVID19-associated psychosis in young patients
with *NO* prior history of mental-illness
publications.aap.org/pediatrics/art… #serverless #womeninstem #itrtg #scicomm #openscience #iot #neuroscience Image
He expressed that "the information system in his brain had been deleted,"
and the government was “coming for him.”
He experienced auditory hallucinations;
“everyone around the world is saying not to let the
doctors do the test” and believed the tests would kill him."
Sars-Cov-2 🦠and ➡️ the 🧠brain
(a partial list of pathology) :
➡️ encephalitis, encephalopathy, seizures, Parkinsonism, altered consciousness, stroke, ataxia, myclonia, hallucinations, psychosis, brain hemorrhaging, vasculitis, coma...
Not just an illness of the 🫁 lungs.
Read 4 tweets
Aug 26
7⃣+ months of Norovirus🦠positivity➕
in this ⚠️Primary Immunodeficiency patient
▪️ Rx-resistant
🧬-> intra-host evolution led to a unique norovirus strain
bit.ly/3RbH53d #bioinformatics #openscience #scicomm #itrtg #raredisease #genomics #immunology Image
Very much in line with what has been seen
in some persistent🦠Sars-Cov-2 infections in immunocompromised hosts.
▪️ viral-clearance failure
▪️ within-host viral evolution/mutations
*the report gives no indication on the fate of the patient.
⚠️Immunocompromised patients ⚠️as atypical
"outliers" with almost every🦠infectious pathogen (circa 2017).
❗️ PLEASE doctors - keep a good 👁️eye on those
with compromised immune-systems
jiac-j.com/article/S1341-… #openscience #scicomm #meded Image
Read 4 tweets
Aug 2
⚠️Beware🦠Omicron:
It doesn't give *⃣ 2 shits *⃣ if you've been infected
with prior variants
...and get💉vaxxed!
wwwnc.cdc.gov/eid/article/28… #bioinformatics #serverless #openscience #snrtg #scicomm #immunology
*⃣ Sorry - I posted the link to the graph
This is the link to the article itself:
wwwnc.cdc.gov/eid/article/28…
The best protection against infection
and/or reinfection with Omicron🦠:
Vaxx/boost💉➕ masking 😷
Read 6 tweets
Jul 16
This will likely have incalculable
repercussions in lives lost.
reut.rs/3ze7sj3 #globalhealth #snrtg #openscience #scicomm #medtwitter #VaccinesSaveLives Image
Expect a likely resurgence of vaccine-preventble pediatric infectious, communicable diseases - according to this study...measles, rubella, mumps, pertussis, polio, rotavirus...
Likely causes of this backslide in childhood vaccination:
▪️ global vaccine-"fatigue"
▪️ hyper-focused attention on one disease (🦠
SarsCov2), while virtually ignoring all others.
Read 4 tweets
Jul 15
Brand 🆕 insight into the mechanism of
anti-interferon (IFN)–γ autoantibodies
- implications for 🧬Inborn Errors of Immunity⚠️
and 🦠SarsCov2
#bioinformatics #openscience #scicomm #immunology #genomics #raredisease
These auto-ABs are linked 🦠to:
1⃣ Primary Immunodeficiencies / "IEIs": susceptibility to certain infections
2⃣ Susceptibility to severe and fatal COVID-19
The anti-interferon (IFN)–γ autoantibody
➡️🦠#COVID19 connection
bit.ly/3yGDbaY #bioinformatics #openscience #scicomm
Read 4 tweets
Jul 12
A large🆕study confirms
the⚠️danger of 🦠SarsCov2
to the #immunocompromised
Take precautions to protect yourself
cdc.gov/mmwr/volumes/7… #WomenInSTEM #openscience #itrtg #scicomm #medtwitter #immunology #raredisease
▪️ 💉vaxx ➕boost💉
▪️😷 mask on and up
▪️📏 practice strategic social-distancing
If you are immunodeficient or immunocompromised,
(👤LIKE ME) ... these 3⃣ things could well save your life.
A news article which accompanies the above research:
"Study highlights need to prioritize
immunocompromised COVID patients"
news-medical.net/news/20220710/… #WomenInSTEM #openscience #scicomm
Read 4 tweets

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