Thread by @1derfultype

Betting for the next best thing in digital #diabetes technology:

'#AID systems & algorithms are very effective.
Unfortunately, they are used by a minority of ppl who cld benefit from them.'
-Steven Russell

#EASD2022 #dedoc°voices #nothingaboutuswithoutus @dedocORG 1/n

Betting for the next best thing in digital #diabetes technology:

'In addition to the challenges of getting hybrid #AID systems, they still require setups. They still require the user to #carbcount for meals & initiate correction boluses.'
-Steven Russell

#EASD2022 #dedoc 2/n

Betting for the next best thing in digital #diabetes technology:

'The #IletBionicPancreas pivotal trial results will be published by end Sept.' -Steven Russell

✅ Only setup needed: @PwD's weight
✅ No #carbcounting
✅ Fully automated

#EASD2022 #dedoc°voices #BetaBionics 3/n

Betting for the next best thing in digital #diabetes technology:

'The 13 wks #IletBionicPancreas pivotal trial results will be published by end Sept.' -Steven Russell

✅ 26% minority population
⬆️ +16% #TIR
⬇️ -0.5% #A1c

#EASD2022 #dedoc°voices #diabetesadvocacy @dedocORG 4/n

Betting for the next best thing in digital #diabetes technology:

'Similar results with #ControlIQ studies whereas the #IletBionicPancreas doesn't require carb counting and insulin parameters.' -Steven Russell

It looks promising ✨

#EASD2022 #dedoc°voices #payitforward 5/n

Betting for the next best thing in digital #diabetes technology:

2 faster insulins #Fiasp & #Lyumjev have:
✅ 15-25min shortened time of peak
⬇️ postprandial #BG
⬇️ mean #BG
↔️ #TIR

#EASD2022 #dedoc°voices #nothingaboutuswithoutus #diabetesadvocacy
@EASDnews @dedocORG 6/n

Betting for the next best thing in digital #diabetes technology:

'With faster insulin, we can clamp the #BG within a very narrow range.' 👇
-Steven Russell

✅ Mean BG in #T1D group: 107mg
✅ Range: 96-128mg
✅ #TIR: 98%
✅ No hypo

#EASD2022 #dedoc°voices @dedocORG 7/n

Betting for the next best thing in digital #diabetes technology:

'Glucagon could take us further.
2 hormones are missing in #T1D:
❌ #insulin beta cells
❌ #glucagon alpha cells are there but no longer respond to hypo.'
-Steven Russell

#EASD2022 #dedoc°voices @dedocORG 8/n

Betting for the next best thing in digital #diabetes technology:

'#glucagon is the most important defence against #hypo ➡️ automatic microdosing of glucagon may prevent severity of hypo as it is absorbed much faster than #insulin.' -Steven Russell

#EASD2022 #dedoc @dedocORG 9/n

Betting for the next best thing in digital #diabetes technology:

7-day #IletBionicPancreas study:
Insulin only ▶️ 72% #TIR
Bi-hormonal ▶️ 79% #TIR & less hypo

'We now have a stable #glucagon analog: Zegalogue (Dasiglucagon).'
-Steven Russell

#EASD2022 #dedoc° 10/n

Betting for the next best thing in digital #diabetes technology:

'In the future, we may have glucose-responsive #insulin that only acts when the glucose is high and is prevented from acting when low.' -Steven Russell

#EASD2022 #dedoc°voices #DOC @EASDnews @dedocORG 11/n

Betting for the next best thing in digital #diabetes technology:

'Possible adjunct therapies to #AID:
✅ Pramlintide
✅ GLP-1 agonists
✅ SGLT-2 inhibitors'
-Steven Russell

#EASD2022 #dedoc°voices
@EASDnews @dedocORG 12/n

Betting for the next best thing in digital #diabetes technology:

Ideal bihormonal #ClosedLoop system:
✅ Automated #glucagon
✅ Smart #insulin
✅ Adjunct drugs

The device has been submitted to the FDA - not yet to Europe 😭

#EASD2022 #dedoc°voices @dedocORG 13/n

Hey @threadreaderapp, pls unroll this 🧵

🙏🙏🙏