Latest #TeamClots preprint on clotting abnormalities in #LongCovid. We demonstrated that the average levels of 6 inflammatory procoagulatory molecules were significantly higher in the soluble fraction of blood in #LongCovid when compared to controls medrxiv.org/content/10.110… 1/n
These werealpha-2-antiplasmin (A2AP), serum amyloid A (SAA), platelet factor 4 (PF4), E-selectin, von Willebrand Factor (VWF) & platelet endothelial cell adhesion molecule-1 (PECAM-1). The mean A2AP level exceeded the upper limit of the lab reference range in #LongCovid 2/n
Considering that large quantities of these molecules have already been detected inside microclots using proteomics, the elevation in plasma/serum means that total levels of these inflammatory mediators are indeed alarming in #LongCovid 3/n
In addition, we found that the addition of PECAM-1 & E-selectin to healthy blood stimulated microclot formation & platelet hyperactivation, signalling a key role for them in the pathological clotting found in #LongCovid 4/n
We conclude that the presence of microclots & these inflammatory molecules points to thrombotic endotheliitis as a key pathological process in #LongCovid. Urgent attention MUST be given NOW to studies of treatments targeting the hypercoagulability 5/n
We have known since the beginning of the pandemic that this is a prothrombotic virus. We cannot let people suffer any longer; treatment trials are needed urgently.
It was a privilege to collaborate with @resiapretorius @dbkell & others on this paper 🙏🏾 6/n
It was a privilege to collaborate with @resiapretorius @dbkell & others on this paper 🙏🏾 6/n
Thank you @loscharlos for picking out the clinically relevant bits!
https://twitter.com/loscharlos/status/1580831993742249984
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