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Yoni Maisel Profile picture
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Nov 16 • 6 tweets • 3 min read
🆕: COVID-19🦠vaxx-💉-response in a cohort of
#immunocompromised children
organ-transplant; stem-cell transplant; rheum, +
- 2 vs 3 dose study
go.nature.com/3hERBn3 #serverless #openscience #scicomm #itrtg #iot #raredisease #datascience #immunology
A majority of the children mounted effective humoral repsonse following 2 doses; increase to near 100% following.
Caveat: these study authors recommend a 3-dose regimen in immunocompromised pediatric patients.
Kids do ⚠️NOT⚠️ have de-facto immunity to 🦠Sars-Cov-2
*⃣ especially immunocompromised kids *⃣
I have read recent case-reports of *fatal* COVID in kids with ▪️Primary Immunodeficiency, ▪️autoimmunity, ▪️rheumatic disease, ▪️cancers, ▪️sickle-cell, ▪️transplants, and more...
I strongly concur with the authors' recommendation of a minumum 💉3-dose regimen in immunocompromised and immunodeficient youngsters - ⚠️ if not contraindicated.
Vunerable kids deserve protection from 🦠Sars-Cov-2.
Getting your immunocompromised kids vaccinated is an act of love.
More case reports of
fatal pediatric COVID
in young immunocompromised patients
in literature today - and it's not even noon.
👥kids with ▪️juvenile arthritis, ▪️brain cancer
▪️autoimmunity, and ▪️infantile IBD.
🙏Please 💉vaxx your ⚠️vulnerable children.

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More from @Primary_Immune

Yoni Maisel Profile picture
Nov 17
A long battle for survival in a
Sars-Cov-2🦠➕Aspergillosis🦠co-infected
⚠️immunocompromised⚠️patient
(post- stem-cell transplant for leukemia)
ncbi.nlm.nih.gov/pmc/articles/P… #bioinformatics #itrtg #datascience #serverless #openscience #iot #raredisease #immunology #COVIDIsAirborne Image
These scenarios are unique to the
⚠️immunocompromised & immunodeficient⚠️.
If you are as such, please do EVERYTHING in your
power to avoid 🦠 Sars-Cov-2 infection:
💉vaxx ➕😷 mask ➕strategic social-📏-distancing.
Kudos to teams at:
Osaka Metropolitan University Graduate School of Medicine,
Osaka, 🇯🇵 Japan,
for saving the life of this critically-ill patient. #openscience
Read 7 tweets
Yoni Maisel Profile picture
Sep 14
▪️ High-profile man on Twitter tweets an article he had no part in writing - gets 100s of RTs & likes, and "thanks."
▪️ Woman who authored the paper after year(s) of hard work, tweets it and gets NO RTs, 1 like, and no "thanks."
F-CK that.
#womeninstem #academictwitter #scicomm
Misogyny and sexism are alive and well.
This is not a 'one-off.' I see it every day.
Man = hero.
Woman = almost zero.
Read 6 tweets
Yoni Maisel Profile picture
Sep 14
🆕: Severe, atypical, post-🦠- #COVID19
neurological🧠 sequelae
💉responsive to IVIg
…mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md… #serverless #womeninstem #openscience #scicomm #snrtg #LongCovid #neurology #immunology
🙏KUDOS and respect to this brave gentleman for consenting to the publication of this video and giving a glimpse into one of the many ways in which 🦠Sars-Cov-2 is affecting the🧠brains of those it infects.
#openscience #scicomm
Protect yourself from 🦠Sars-Cov-2,
please.
It's messing up 🧠 brains.
Read 4 tweets
Yoni Maisel Profile picture
Sep 12
🆕: ⚠️Not so mild 🦠#COVID19
in this immunosuppressed patient
- development of atypical, severe, acute 🧠 meningitis
ijidonline.com/article/S1201-… #bioinformatics #womeninstem #openscience #scicomm #snrtg #genomics #immunology Image
This patient could not have wound up in better hands:
National Institute of Infectious Diseases
“Lazzaro Spallanzani” IRCCS- Rome, 🇮🇹 Italy
👍 great job treating this patient,
sequencing and monitoring🧬the 🦠strain,
...and saving her life
#openscience #scicomm
I have found only a handful of reports in literature of
🦠Sars-Cov-2 induced🧠 meningitis. I thought there would be more. Caveat: it's exceedingly rare, but it does happen.
Read 4 tweets
Yoni Maisel Profile picture
Aug 28
🦠 ->🧠
I'm seeing a noticeable ⬆️uptick
in these disturbing reports:
#COVID19-associated psychosis in young patients
with *NO* prior history of mental-illness
publications.aap.org/pediatrics/art… #serverless #womeninstem #itrtg #scicomm #openscience #iot #neuroscience Image
He expressed that "the information system in his brain had been deleted,"
and the government was “coming for him.”
He experienced auditory hallucinations;
“everyone around the world is saying not to let the
doctors do the test” and believed the tests would kill him."
Sars-Cov-2 🦠and ➡️ the 🧠brain
(a partial list of pathology) :
➡️ encephalitis, encephalopathy, seizures, Parkinsonism, altered consciousness, stroke, ataxia, myclonia, hallucinations, psychosis, brain hemorrhaging, vasculitis, coma...
Not just an illness of the 🫁 lungs.
Read 4 tweets
Yoni Maisel Profile picture
Aug 27
Relapsed/persistent
🦠Sars-Cov-2 escaped detection in these
2⚠️immunocompromised patients
...good thing these inquistive teams dug "deeper."
sciencedirect.com/science/articl… #bioinformatics #openscience #itrtg #COVID19 #iot #scicomm #immunology #virology
"2 cases occult SarsCov2 in immunocompromised hosts: Dx originally not suspected due to repeat negative SARS-CoV-2 from NP specimens
isolation of viable SARS-CoV-2 virus + nucleocapsid + spike-protein antigen in lung tissue on immunohistochemistry 3-months from primary infection"
"suggests ongoing 🦠viral persistence and replication as a driver of the lung parenchymal changes,
which resolved after antiviral treatment."
Both patients survived:
discharged on days 80 and 100 respectively.
Read 4 tweets

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