These scenarios are unique to the
⚠️immunocompromised & immunodeficient⚠️.
If you are as such, please do EVERYTHING in your
power to avoid 🦠 Sars-Cov-2 infection:
💉vaxx ➕😷 mask ➕strategic social-📏-distancing.
Kudos to teams at:
Osaka Metropolitan University Graduate School of Medicine,
Osaka, 🇯🇵 Japan,
for saving the life of this critically-ill patient. #openscience
A reminder that stem-cell-🧪transplantation
involves immuno-suppression, leaving patients highly-susceptible to severe 🦠infections.
⚠️Stem-cell transplant patients have had among the
⬆️highest fatality-rate of the pandemic,
up to 2⃣8⃣% in some cohort studies.
Please protect and shield yourself from the virus - all.
That goes 2⃣✖️(double)
for my ⚠️immunocompromised ⚠️
sisters and brothers,
...who are the most susceptible to severe and fatal COVID-19.
"Aspergillus fumigatus"🦠: the fungal pathogen which co-infected this COVID-19 patient.
An opportunistic pathogen seen in numerous COVID cases.
Has increased COVID fatality-rate exponentially,
especially in the immunocompromised.
(image: JAMA) #scicomm#openscience
A majority of the children mounted effective humoral repsonse following 2 doses; increase to near 100% following.
Caveat: these study authors recommend a 3-dose regimen in immunocompromised pediatric patients.
Kids do ⚠️NOT⚠️ have de-facto immunity to 🦠Sars-Cov-2
*⃣ especially immunocompromised kids *⃣
I have read recent case-reports of *fatal* COVID in kids with ▪️Primary Immunodeficiency, ▪️autoimmunity, ▪️rheumatic disease, ▪️cancers, ▪️sickle-cell, ▪️transplants, and more...
▪️ High-profile man on Twitter tweets an article he had no part in writing - gets 100s of RTs & likes, and "thanks."
▪️ Woman who authored the paper after year(s) of hard work, tweets it and gets NO RTs, 1 like, and no "thanks."
F-CK that. #womeninstem#academictwitter#scicomm
Misogyny and sexism are alive and well.
This is not a 'one-off.' I see it every day.
Man = hero.
Woman = almost zero.
🙏KUDOS and respect to this brave gentleman for consenting to the publication of this video and giving a glimpse into one of the many ways in which 🦠Sars-Cov-2 is affecting the🧠brains of those it infects. #openscience#scicomm
Protect yourself from 🦠Sars-Cov-2,
please.
It's messing up 🧠 brains.
This patient could not have wound up in better hands:
National Institute of Infectious Diseases
“Lazzaro Spallanzani” IRCCS- Rome, 🇮🇹 Italy
👍 great job treating this patient,
sequencing and monitoring🧬the 🦠strain,
...and saving her life #openscience#scicomm
I have found only a handful of reports in literature of
🦠Sars-Cov-2 induced🧠 meningitis. I thought there would be more. Caveat: it's exceedingly rare, but it does happen.
He expressed that "the information system in his brain had been deleted,"
and the government was “coming for him.”
He experienced auditory hallucinations;
“everyone around the world is saying not to let the
doctors do the test” and believed the tests would kill him."
Sars-Cov-2 🦠and ➡️ the 🧠brain
(a partial list of pathology) :
➡️ encephalitis, encephalopathy, seizures, Parkinsonism, altered consciousness, stroke, ataxia, myclonia, hallucinations, psychosis, brain hemorrhaging, vasculitis, coma...
Not just an illness of the 🫁 lungs.
"2 cases occult SarsCov2 in immunocompromised hosts: Dx originally not suspected due to repeat negative SARS-CoV-2 from NP specimens
isolation of viable SARS-CoV-2 virus + nucleocapsid + spike-protein antigen in lung tissue on immunohistochemistry 3-months from primary infection"
"suggests ongoing 🦠viral persistence and replication as a driver of the lung parenchymal changes,
which resolved after antiviral treatment."
Both patients survived:
discharged on days 80 and 100 respectively.