The less we eat, the longer we live
1. This seems to be true.
A recent extensive review of studies done in geographies with maximum 100+ aged people showed that most of them practiced some form of calories restriction (CR) right from childhood.
#fasting #Longevity #MedTwitter
1. This seems to be true.
A recent extensive review of studies done in geographies with maximum 100+ aged people showed that most of them practiced some form of calories restriction (CR) right from childhood.
#fasting #Longevity #MedTwitter
2. Calorie restriction (CR) is defined as consuming fewer (10-30% lower) calories as compared to usual.
This can be achieved by either intermittent fasting, or time-restricted feeding or substantially reducing carbohydrate intake.
#nutrition #HealthyEating
This can be achieved by either intermittent fasting, or time-restricted feeding or substantially reducing carbohydrate intake.
#nutrition #HealthyEating
3. In ageing, #Insulin increases and insulin sensitivity decreases, which increase the risk of #diabetes, #obesity and #cardiovascular diseases. CR reverses these- reduces insulin levels and increases insulin sensitivity. #Glucose levels also reduce with CR.
4. CR causes a shift from carbohydrate to fat metabolism, leading to fatty acid oxidation and ketogenesis. Iso-caloric #ketogenic diet is known to increase longevity.
5. CR causes lowering of T3, with no changes in T4 and TSH levels. This is associated with longevity. In a study, people with low-normal #thyroid hormone levels lived 3.5 years longer than people with normal-high thyroid hormone levels.
6. CR has anti-inflammatory effects. Several markers of inflammation reduce after CR. Inflammation is the leading cause behind several serious diseases such as heart attack, stroke, cancer, Alzheimer's disease and Parkinson's disease.
7. CR has favorable effects on gut microbiome. CR promotes probiotic species and reduce proinflammatory species in the gut.
8. Summary-
Nutrition plays a major role in increasing lifespan. Calorie restriction is the most important of all.
For maximum benefits, CR should be started right from early childhood (school going age).
Nutrition plays a major role in increasing lifespan. Calorie restriction is the most important of all.
For maximum benefits, CR should be started right from early childhood (school going age).
9. Caution: CR may not suit all. Those who are already underweight, or suffer from serious diseases, are old, or are at risk of sarcopenia (muscle loss) should be careful while starting CR. Those indulging in high volume exercise should also exercise caution in limiting calories
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