Raj Rajnarayanan Profile picture
Jan 4 19 tweets 17 min read
#COVID19 #VariantDashboard - #UnitedStates

Holiday season - Low seq count this 15day period!

TOP lineages (#15DAYTRENDS):

24.0% XBB.1.5
11.4% BQ.1.1
9.5% BQ.1.22
9.2% BQ.1
3.6% XBB.1
2.6% BQ.1.1.3

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 01/03/2023

1/n Image
Sequence count by US State

New York and California have submitted a large share of sequences with specimen collection dates in the last 15 days.

Appears like a push-pull between BQ.1.1. vs XBB.1.5 as more sequences from outside NE USA are being submitted.

2/n Image
Granular details -#VariantDashboard #USA #15DayTrends

3/n Image
.@CDCgov updated variant proportions estimates on 12/30/2022 (updated every Friday)

Several BQ* are circulating at >1% especially BQ.1.1.3/4, BQ.1.22 is a good candidate to be included in CDC's Nowcast estimates next week!



4/n
#Global #VariantSoup 01/03/2023

Top lineages with at least 5 key convergent #Spike mutations (#30DayTrends):

BQ.1.1 (24.27%)
BQ.1 (8.75%)
BQ.1.22 (4.09%)
XBB.1 (3.99%)
XBB.1.5 (2.96%)👀
CH.1.1 (2.91%)👀
BN.1.3 (2.23%)
BQ.1.2 (2.16%)
BQ.1.1.4 (1.98%)
BQ.1.1.20 (1.75%)

5/n
Predicted Immune Escape and ACE2 binding of top lineages in USA (relative to BA.2)

Bivalent boosters (OG/Omicron.BA.5) will potentially protect the boosted from getting severe disease/hospitalizations.

Please get #boosted ASAP!

public.tableau.com/app/profile/ra…

6/n Image
#Hospital #Capacity - (by State/Division)

All hospitalizations not just COVID-19

public.tableau.com/app/profile/ra…

7/n Image
#COVID19 #Hospitalizations in the #UnitedStates

Please get #boosted (especially > 50 yr old and immune compromised) and #MaskUP!

Hospital Tracker (by States, by age group): public.tableau.com/app/profile/ra…

8/n
Status of the latest #COVID19 Wave in #NewYork #BellwetherState

XBB.1.5 is the dominant #SARSCoV2 lineage in NY

Top Lineages (#15DAYTrends):

XBB.1.5 (54.9%)👀🚀
BQ.1.1 (9.8%)⬇️
XBB.1 (6.0%)
BQ.1 (5.2%)
BQ.1.1.4 (2.6%)
BQ.1.1.3 (2.2%)
BQ.1.3 (1.9%)
..
CH.1.1 (1%)

9/n ImageImage
Rise of highly immune evasive XBB* family of lineages especially XBB.1.5 (Key mutation: Spike F486P) in NY is concerning

fortune.com/well/2022/11/0…

10/n
BQ* Hotspots - #USA #15DayTrends

11/n Image
Recombinant lineage hotspots - #USA #15DayTrends

12/n ImageImage
Adding BN* & CH.1.1* (BA.2.75's sub-lineages) to the watch list

13/n Image
Tracking the current #COVID19 wave, variant soup and #Hospitalizations 👀 in #Massachusetts

2 sequences with sample collection dates in the last 15 days (1 each of XBB.1 & XBB.1.5).

14/n Image
Tracking the current #COVID19 wave, variant soup and #Hospitalizations 👀 in #Connecticut

XBB.1.5 is the top circulating lineage in CT

[low sequence count]

16/n ImageImage
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #NewJersey

XBB.1.5 is the top circulating lineage in NJ

[Low sequence count]

17/n ImageImage
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #Virginia

BQ.1.1 & XBB.1.5 are the top circulating lineages in VA

[low sequence count]

18/n ImageImage
Tracking the current #COVID19 wave, variant soup and #Hospitalizations in #Arkansas

Only one sequence with specimen collection dates within the last 15 days is available (BQ.1.22)

[low sequence count]

19/n Image

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More from @RajlabN

Jan 6
#COVID19 #VariantDashboard - #UnitedStates

Interesting tug or war between BQ.1.1 vs XBB.1.5

TOP lineages (#15DAYTRENDS):

19.4% BQ.1.1
17.0% XBB.1.5
10.8% BQ.1
3.3% XBB.1
2.8% BQ.1.1.4
2.4% BQ.1.1.3

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 01/05/2023

1/n Image
Note: Thanks to Emily Smith (tweet below), misassigned BQ.1.22s were reassigned now to BQ.1.1 or BQ.1.x.y (will check them again and update if there are any additional changes)



2/n
Sequence count by US State

Large share of sequences from outside NE States with specimen collection dates in the last 15 days. The proportion of BQ.1*/BQ.1.1* >> XBB.1.5 outside NE states. XBB.1.5 is expected to outcompete all other circulating lineages soon.

2/n Image
Read 18 tweets
Jan 5
Tracking XBB.1.5* lineage over time | 01/05/2023

Total Sequence Count
- Global: 4,064
- USA: 3,597

Earliest sample collection date: 10/22/22 (NY, USA)*
Now circulating in 33 countries

Tracker: public.tableau.com/app/profile/ra…

* [excluding samples with date errors] Image
Tracking XBB.1.5* lineage over time in North America | 01/05/2023

Northeast USA is a major hotspot (mainly NY & NE USA)

Emerging hotspot outside USA: Ontario, Canada Image
Tracking XBB.1.5* lineage over time in Europe | 01/05/2023

Emerging hotspots #UnitedKingdom, #Denmark, #Germany, #Austria Image
Read 4 tweets
Jan 5
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (#15DAYTRENDS):

18.9% XBB.1.5
14.5% BQ.1.1
9.6% BQ.1
6.6% BQ.1.22
3.2% XBB.1
2.4% BQ.1.1.4
2.3% BQ.1.3
2.1% BQ.1.12
2.0% BQ.1.1.3

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 01/04/2023

1/n Image
Sequence count by US State

New York, California, North Carolina, Washington, Virginia and Florida have submitted a large share of sequences with specimen collection dates in the last 15 days.

2/n Image
Granular details -#VariantDashboard #USA #15DayTrends

3/n Image
Read 21 tweets
Jan 4
Tracking XBB.1.5* lineage over time | 01/04/2023

Total Sequence Count
- Global: 3,582
- USA: 3,161

Earliest sample collection date: 10/22/22 (NY, USA)*

Tracker: public.tableau.com/app/profile/ra…

* [excluding samples with date errors] Image
Tracking XBB.1.5* lineage over time in North America | 01/04/2023

Northeast USA is a major hotspot (mainly NY) Image
Tracking XBB.1.5* lineage over time in Europe | 01/04/2023

Emerging hotspots #UnitedKingdom, #Denmark, #Germany, #Austria Image
Read 4 tweets
Jan 3
#VariantDashboard #India - #30DayTrends

>> Low Sequence Count (n=79) <<

Top circulating lineages:

XBB.1 (14.5%)
BQ.1.1 (9.6%)
XBB.1.5 (9.6%)
XBB (8.4%)
XBB.2 (7.2%)
BQ.1 (6.0%)
BY.1 (6.0%)
BA.5.2 (3.6%)

Tracker: public.tableau.com/app/profile/ra…

Updated: 01/02/2023
Granular details - #VariantProportions #India 1/2/23

XBB* is still the dominant circulating group of lineages in India

XBB.1.5* has entered the conversation in #Maharashtra, #Gujarat and #Telangana
Variant landscape in Indian States with reported XBB.1.5* sequences #30DayTrends (#Maharashtra, #Gujarat and #Telangana)
Read 4 tweets
Jan 3
#COVID19 #VariantDashboard - #UnitedStates

Holiday season - Low seq count this 15day period!

TOP lineages (#15DAYTRENDS):

35.7% XBB.1.5
13.4% BQ.1.1
8.5% BQ.1
4.1% XBB.1
2.8% BQ.1.1.4
2.6% BQ.1.1.3

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 01/02/2023

1/n
Sequence count by US State

New York has submitted a HUGE SHARE of sequences with specimen collection dates in the last 15 days.

2/n
Granular details -#VariantDashboard #USA #15DayTrends

3/n
Read 18 tweets

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