Time-restricted eating alone may not result in long-term weight loss

1. Time-restricted eating (TRE), a form of #IntermittentFasting (IF), has gained popularity for #weightloss.
However, weight loss was not seen in a recently published study with TRE.
#obesity #MedTwitter
2. 547 participants (78% women, mean age 51 years, mean BMI 30.8) were followed up for 6 years.
*Mean interval from first to last meal was 11.5 hours and was not associated with weight change.
*The number of #meals per day was positively associated with weight change.
3. Total daily number of large (>1000 calories) and medium meals (500-1000 calories) was associated with increased weight over follow‐up time, while total number of small meals (<500 calories) was associated with decreasing weight.
4. Conclusion
*Meal frequency and meal sizes, rather than the timing of meals, is probably a stronger determinant of weight gain over time.
*In addition to "eating window", what one eats and how much one eats, are more important determinants of long-term weight loss.

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More from @hyderabaddoctor

Jan 25
Canadian guidance on #alcohol consumption
(January 2023)
1. Young people should delay alcohol use for as long as possible.

2. Individuals should not start to use alcohol or increase their alcohol use for health benefits.

3. Any reduction in alcohol use is beneficial.
4. When pregnant or trying to get pregnant, no amount of alcohol is safe
5. When breastfeeding, not drinking is safest
6. Consuming no drinks is associated with better health & better sleep,
7. Three to six drinks/week raise the risk of developing breast, colon & other cancers
8. Seven or more drinks per week increase the risk of #heart disease or #stroke.

9. Each additional drink "radically increases" the risk of these health consequences.

10. Consuming one or two standard drinks weekly will likely not have alcohol-related consequences.
Read 4 tweets
Jan 25
Low dose exercise regimen is quite effective in patients with knee #osteoarthritis (OA)

1. Patients with knee OA suffer from #knee pain, poor knee function and poor quality of life.
A recent study compared low dose versus high dose exercise regimens in people with knee OA.
2. High-dose #exercise therapy lasted for 70-90 minutes consisting of 11 exercises, whereas low dose exercise therapy (consisting of 5 exercises) lasted for 20-30 minutes.
Both were performed three times a week.
Patients were followed up at 3, 6 and 12 months.
3. Both groups improved over time, but there were no benefits of high-dose therapy in most comparisons.
However, small benefits with high-dose exercise were found for knee function in sports and recreation and for quality of life (QoL).
doi.org/10.7326/M22-23…
Read 4 tweets
Jan 24
Ignoring transient vision loss in right eye could have been risky for a 50-year old

1. 50-year old Mr Raj presented with symptoms of sudden onset loss of vision in right eye, which recovered in 30 minutes. It first occurred 30 days back and recurred a week back.
#MedTwitter
2. As his #vision had completely recovered a month back, Raj ignored it and did not seek medical help. When it recurred for the second time, he decided to see an #ophthalmologist.
Eye check up was normal and he was referred to a #neurologist.
#neurotwitter
3. On enquiry, he had complete loss of vision in right eye on both the occasions, which lasted for 30 and 20 minutes respectively. He had no headache or any other neurological symptoms.
He was taking medicines for high BP for two years.
The diagnosis was clear by now.
Read 9 tweets
Jan 24
"Burning the midnight oil" the night before exams results in poorer grades
1. It is common to see students studying late nights especially closer to #examinations. But does studying extra at the cost of missing #sleep result in better academic performance?
#AcademicTwitter
2. A survey was conducted among student pharmacists to correlate sleep duration and course grades. About 300 students of pharmacy (first to third years) were included in the survey.
Reference:
doi.org/10.5688/ajpe79…
3. More than half of student pharmacists obtained less than 7 hours of sleep at night during a typical school week (55%) and a large majority on the night prior to an examination (82%).
Read 7 tweets
Jan 23
Excess of vitamin B12 may be hazardous

1. Vitamin #B12 deficiency is known to cause anemia, peripheral neuropathy, dementia, psychosis and skin pigmentation. Vitamin B12 supplementation is needed in them, however, #vitaminB12 excess may have adverse effects on health and life.
2. In a recent study, >5500 people (mean age 53 years) were followed up for 8.2 years.
Those with high plasma vitamin B12 concentration had 25% higher risk of all-cause death.
The mechanism of increased death is unknown.
#MedTwitter #nurtition #vitamin
3. Older age, high blood pressure, poorer kidney function, as well as increased concentrations of liver enzymes, were positively associated with higher plasma concentrations of vitamin B12. So, these groups should be more cautious while taking vitamin B12 supplementation.
Read 8 tweets
Jan 21
My resting #heart rate (RHR) during past last week ranged from 41 to 47 bpm (average HR 45 bpm)

1. Lower HR (without use of medications) has several health-related benefits.
#MedTwitter #fitness #Health Image
2. Middle aged people with RHR >70 bpm have 68% higher risk of death and 20% higher risk of coronary events during 10.5 year follow up as compared to those with RHR <70 bpm.
doi.org/10.1007/s00392…
3. Compared to men with RHR ≤ 50, those with RHR > 90 had three times higher risk of death (during 16 year follow up)
With RHR as a continuous variable, risk of death increased with 16% per 10 beats per minute (bpm).
doi.org/10.1136/heartj…
Read 9 tweets

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