Antonio Guerrero Profile picture
Jun 3 12 tweets 10 min read Twitter logo Read on Twitter
Human #intestinal #spirochetosis:
✔️#sexual #transmitted infections
✔️of the large intestine by anaerobic spirochetes of the genus Brachyspira spp.
1/10

🖊️A De Gea, @alfredomaldo ,@clarapath, @MarianaDazAlmi1, @alirri, Raquel Escudero, et al.
👇
sciencedirect.com/science/articl… Colonoscopic biopsy. In rou...
@alfredomaldo @clarapath @MarianaDazAlmi1 @alirri Gastrointestinal symptoms such as abdominal pain, proctitis, or chronic diarrhea are the most common manifestations.

Most cases with accompanying symptoms show improvement with metronidazole antibiotic therapy.
2/10

#IntestinalSpirochetosis
Routine staining methods (haematoxylin & eosin & Warthin-Starry) can identify spirochetes on the surface of enterocytes.
Histologically, characteristic findings include a decrease in microvilli &a predominantly eosinophilic inflammatory infiltrate.
3/10

#Pathologists #pathology Colonoscopic biopsy compare...
Microbiological Diagnosis: Stool polymerase chain reaction (PCR) can identify the presence of Brachyspira spp. bacteria at the microbiological level.
4/10

#microbiology #pathTwitter
Epidemiological Trends: Recent studies have reported an increasing number of HIS cases among people living with #HIV (PLHIV) and men who have #sex with men.
This has raised the possibility of HIS being classified as a sexually transmitted infection (#STI).

5/10
36 cases of HIS with the majority being males.
· 29.4% of the patients were PLHIV.
· 56% were men who had sex with men.
· The most frequent clinical manifestation was chronic diarrhea (47%).
· Up to 25% of the subjects presented with clinical proctitis.
6/10

#SexualHealth
39% of the patients had been diagnosed with an #STI in the previous two years. This characteristic was more frequent in PLHIV (90% vs. 28%) compared to patients without HIV infection.
#Syphilis was the most frequently associated STI with a diagnosis of HIS (31%).
6/10
Human Intestinal Spirochetosis has gained significance due to:
✔️ its association with #HIV infection,
✔️a history of #STIs, and
✔️#immunosuppression
6/10
A total of 36 cases of HIS were identified, with the majority being males.
· 29.4% of the patients were #PLHIV.
· 56% were men who had #sex with #men.
· The most frequent clinical manifestation was chronic diarrhea (47%).
· Up to 25% of the subjects: clinical proctitis.
6/10
39% of the patients had been diagnosed with an STI in the previous two years.
This characteristic was more frequent in PLHIV (90% vs. 28%) compared to patients without #HIV infection.

#Syphilis was the most frequently associated STI with a diagnosis of HIS (31%).
7/10
Human #Intestinal #Spirochetosis has gained significance due to its:
✔️association with HIV infection,
✔️a history of STIs, and
✔️immunosuppression.

9/10
Conclusion: This study highlights the association between HIS and sexually transmitted infections, particularly in individuals living with HIV and those with a history of STIs.
10/10

#HIS #IntestinalSpirochetosis #STI #SexualHealth

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More from @guerreroespejo

Jun 5
A 44-yo♂️, HIV +, CD4 cell count of 86/mL, viral load of 35,900 copies/mL: a 1-month history of fevers and pruritic blackish-brown lamellated plaques on the limbs and scalp.
¼
👇
DOI: 10.1056/NEJMicm2213894
#IDtwitter #dermatology Ming J. Liu, M.D., and Wei ...
A RPR titer of 1:32.
A Treponema pallidum particle agglutination: ➕.
A skin-biopsy of the left forearm 🔬: diffuse dermal lymphocytes and histiocytes admixed with a plasma-cell infiltrate.

MALIGNANT SYPHILIS
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#microbiology #dermpath #RareInfection
Malignant #syphilis:
- uncommon form of secondary syphilis
- primarily affects immunocompromised persons.
-skin manifestations are varied, ranging from ulceronodular lesions to oyster shell–like crusts
3/4

#primarycare #MedTwitter #Awareness
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May 17
Lactante, un mes de vida: fiebre, placa en la cara ligeramente sobreelevada, eritematosa, con coloración anaranjada periférica, delimitada, y con aumento de temperatura a la palpación
1/7

🖊️F Rivera y col. continuum.aeped.es/courses/info/9… @ContinuumAEP @aepediatria
#AtencionPrimaria Image
@ContinuumAEP @aepediatria ERISIPELA
✔️infección superficial que afecta a la dermis superior, el tejido celular subcutáneo y a veces al sistema linfático,
✔️causada en la mayoría de los casos por S. pyogenes o estreptococos de los grupos B, C o G.
2/7

#urgencias #microbiología
@ContinuumAEP @aepediatria Origen: interrupción de la barrera cutánea por picaduras de insecto, erosiones, etc.
Comienzo: agudo
Placa eritematosa con bordes bien definidos y ligeramente elevados
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Frecuente: adenopatías regionales.
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#pediatria #MIR
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May 16
A 31-YO♂️, #sexually active with 2♂️partners in the previous month: 8 days before redness of the R eye, an itchy perianal rash & rectal pain; scattered, tender, shallow ulcers & pustules on chest (A), abdomen (B), back (C) & perianal (D)
1/9

nej.md/44ILgLy
#proctology Image
PCR from the perianal vesicel:➕for nonvariola orthopoxvirus DNA.
Species-specific PCR: ➕for #mpox virus, clade II.

The patient reported a new rash with numerous ulcer on his chest, abdomen, and back

MPOX (formerly known as #monkeypox)
2/9

#MolBiol #virology
During the next 2 days, the patient took tecovirimat & reported redness & discomfort of the right eye and become painful

He had learned that mpox had been diagnosed in one of his #sexual partners from the previous month.

Likely MPOX CONJUNTIVITIS
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#ophthalmology #IDtwitter On examination of the right...
Read 9 tweets
Apr 11
An 85-YO in rural Mississippi: months of tender, erythematous plaques & edema on bilateral hands extending to the elbows & on feet extending below the knees with significant pain

🔬skin granulomatous inflammation & numerous AFB
Mycobacterial🧫:➖
1/19

#IDtwitter #dermatology ImageImage
A repeat skin extensive granulomatous inflammation (A), with Ziehl-Neelsen stain clusters of acid-fast bacilli throughout the dermis (B).
Kinyoun stain >9 AFB/high-power field (C & D).
2/19

DOI: doi.org/10.1128/jcm.00…
#dermpath #microbiology (A) Skin biopsy specimen, h...
Molecular identification: 100% identity to multiple Mycobacterium leprae

BORDERLINE LEPROMATOUS LEPROSY WITH REVERSAL REACTION
3/19

#MedTwitter #MolBiol
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Mar 3
A 44-YO♂️, stayed in a rural cottage of France 2 weeks previously: cramping upper abdominal pain with watery diarrhea.
He had passed what he thought were worms in his feces
Eosinophilia
1/6

doi.org/10.1093/cid/ci…
#GITwitter #IDtwitter #microbiology “Worm” specimen brought to clinic by patient (petri dish
The specimens: identified as the larvae of the drone fly, Eristalis tenax
These larvae are 2.5–3 cm in length; the posterior tube gives them the name of “rat-tailed maggots”

INTESTINAL MYASIS CAUSED BY ERISTALIS TENAX LARVA
2/6

doi.org/10.1093/cid/ci…
#parasites #GIPath #Doctor “Worm” specimen brought to clinic by patient (petri dish
Myiasis caused by E. tenax:
✔️rare but have been
✔️reported from various countries including Europe
✔️most often intestinal myiasis, but cases of infestation of the nasal cavity, urinary tract, and vagina have been described.
3/6

#Doctor #MedStudentTwitter
Read 6 tweets
Feb 27
3 años ♀️, padre con lesiones cutáneas similares: lesiones cutáneas polimorfas localizadas en los glúteos, con elementos papulares, vesiculares y pustulosos umbilicados
1/13

🖊️M Roguera y col. @hgermanstrias @aepediatria
DOI: 10.1016/j.anpedi.2022.09.006
#pediatria #infecciosas Lesiones cutáneas en glúteo izquierdo. Detalle de las lesi
@hgermanstrias @aepediatria Se confirmó en el padre la infección por virus de la viruela del mono (MPXV).

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VIRUELA DEL MONO (Mpox)
2/13

#MolBiol #virology #virología
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No hubo complicaciones ni nuevas lesiones en el seguimiento.
3/12

#IDtwitter #microbiología
Read 12 tweets

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