Discover and read the best of Twitter Threads about #neurodegeneration

Most recents (21)

🧠Do It Again🧠

"Researchers at the Technion-Israel Institute of Tech
activated certain combinations of neurons in healthy
mice, who had no physical problems at all, and watched
inflammation suddenly appear.
This illustrates the power of the BRAIN to initiate
physical illness>
The experiment, which involved dozens of mice, suggested that at least some PSYCHOSOMATIC illness is caused by the brain “REPLAYING” an episode of physically induced illness to the body...This suggests that the brain STORES some kind of representation of inflammatory conditions>
that mice experience, and has a way of causing the same inflammation..."I was surprised to see the effect so clearly, with inflammation starting soon after neurons were activated, even though there was NO PATHOGEN or other physical trigger,” Rolls said.>…
Read 5 tweets
With A Little Help From My Friends

"If you’re a Covid case in Chertow’s emerging pathogens lab, you’re not there for treatment; you’re the subject of an autopsy.
The man died at the hospital, tested NEGATIVE. for SC2, so he doesn’t fit the definition of a COVID-RELATED fatality>
He succumbed to viral MYOCARDITIS, or inflammation of the heart muscle. Chertow’s sleuthing points to the CORONAVIRUS as the culprit">…
Vaxxine Induced Enhanced Disease

"But better spike protein antibodies are HORRIBLY maladaptive for future strains and actually the molecular basis for Vaccine Induced Enhanced Disease. Antibodies that DON'T NEUTRALIZE the virus only HELP it.>…
Read 17 tweets
The Sign

...evidence that a circulating 3-microRNA SIGNATURE correlates with cognitive function, is linked to COGNITIVE DECLINE, that the 3 microRNAs regulate processes important for neuronal plasticity in the adult brain and that the signature serves as a target for RNA>
therapeutics. These data provide unprecedented evidence for the view that the blood microRNAome could be suitable as molecular biomarker for neuropsychiatric and neurodegenerative diseases>
Alzheimer’s disease (AD) is usually diagnosed at an advanced stage of molecular pathology... This study aimed to identify a minimally invasive BIOMARKER that can help to identify individuals at RISK for COGNITIVE DECLINE BEFORE clinical MANIFESTATION>
Read 12 tweets
🧠 Brain Damage 🧠

....a new strategy to probe the effects of SC2 on human brains in a linked alveolus-BBB organ chip platform.
The new multi-organ platform allows to recapitulate
the essential features of human alveolar-capillary
barrier and blood-brain barrier in a>
microgluidic condition by co-culturing the organ-specific cells. The results reveal direct SC2 exposure has no obvious effects on BBB chip alone. While, infusion of endothelial medium from infected alveolus chips can cause BBB DYSFUNCTION and NEUROINFLAMMATION on the linked chip>
platform, including BRAIN ENDOTHELIUM DISRUPTION, GLIAL CELL ACTIVATION and inflammatory CYTOKINES findings suggest that SC2 could induce neuropathological alterations, which might not result from direct viral infection through hematogenous route>
Read 5 tweets
⚡️ Wake Up ⚡️

We assume that the subcutaneous and the potential lymph node uptake might be related to an INDUCED INFLAMMATION with PEPTIDES DEPOSITION, as amyloid-beta peptides are involved in the systemic inflammatory process such as in the physiopathology
of Alzheimer's>
disease and chronic, low-level systemic inflammation may EXACERBATE THE Aβ deposition. Such induced inflammation...may be further enhanced in AD patients by the amyloid-beta presence. In this sense...the INTRACELLULAR IMMUNOREACTIVITY was significantly INCREASED by the SarsCoV2>
pseudovirus in the presence of Aβ1-42 (a strong indicator of AD with HIGH AFFINITY for SC2 SPIKE PROTEIN S1 subunit) compared to SC2 pseudovirus alone. Interestingly, they also observed that Aβ1-42 significantly increased SC2 infectivity>
Read 5 tweets
🩸 Blood and Sand ⌛️…
-COVID-19 is a blood and blood vessel disease.
-Current treatment protocols are actively harmful to patients
-Early treatment interventions have been suppressed in favor of vaccines and expensive patented drugs
- Natural immunity confers protection against all of the virus’s proteins, and not just one.
-Vaccines will do more harm than good.
-The vaccine and the virus were made by the same people.
Read 6 tweets
🚑 One Thing Leads to Another 🚑

Fire them...When you have a heart attack may there be no EMS (oops, no paramedics available!) and no staffed bed, thus.... hope you can fix your own cardiac blockage since you FIRED the people who would otherwise assist.
According to the Office for National Statistics, since July 2 there have been 9,619 EXCESS DEATHS in England and Wales, of which 48% were NOT CAUSED by Covid-19.

So if all these extra people are not dying from coronavirus, what is killing them?>
Data from Public Health England shows that during
that period there were 2,103 extra death registrations with ISCHEMIC HEART DISEASE, 1,552 with HEART FAILURE, as well as an extra 760 deaths with cerebrovascular diseases such as STROKE>
Read 6 tweets
Why Are We Vaxxinating Children Against COVID-19?

Clinical trials for these💉were VERY SHORT-TERM
(a few months), had samples not representative of
the total pop., and for adolescents/children, had
poor predictive power because of their SMALL SIZE.
Further, the clinical trials>
did NOT ADDRESS changes in BIOMARKERS that could serve as EARLY WARNING INDICATORS of elevated PREDISPOSITION to SERIOUS DISEASES. Most importantly, the clinical trials did not address LONG-TERM EFFECTS that, if serious, would be BORNE by CHILDREN/ADOLESCENTS for potentially>
DECADES. A novel best-case scenario cost-benefit ANALYSIS SHOWED very conservatively that there
are 5 X'S THE NUMBER OF DEATHS attributable to each💉vs those attributable to COVID
in the most vulnerable 65+ demo. The risk of
Read 5 tweets
Does It Ever Cross Your Mind?

In the brain, both in the cortical and in the medulla and in the region of the basal nuclei, pronounced pericellular and perivascular edema, diapedesis and focal hemorrhages with saturation of adjacent brain tissue with blood were found.>
It is believed that violations of permeability of the blood-brain barrier and associated neural tissue damage are the result of the cytokine storm. Hemmoragic findings in the brain were found in seven cases.>…
Microscopic findings in other organs in COVID-19 patients. H
Read 10 tweets
🏠This Old House🏚️

Here we show that expression of either the SARSCoV2 spike sufficient to INDUCE FUSION BETWEEN INTERCONNECTED NEURONS,
as well as between neurons and glial cells.
This PHENOMENON is OBSERVED ACROSS SPECIES, from nematodes to mammals>
including human embryonic stem cells-derived neurons and brain organoids.
We show that fusion events are PROGRESSIVE, CAN OCCUR BETWEEN DISTANT NEURITES, and lead to the
FORMATION OF MULTICELLULAR SYNCYTIA. Finally, we reveal that in addition to intracellular molecules>
…some viruses do not kill their host cells, and the CHRONIC NEUROLOGICAL SEQUELAE of these infections cannot be explained by the loss of infected neurons...>
Read 8 tweets
Insane in The Membrane

The most comprehensive molecular study to date of the brains of people who died of COVID turned up unmistakable signs of inflammation and impaired brain circuits....The brains of patients who died from severe COVID-19 showed PROFOUND MOLECULAR MARKERS of>
INFLAMMATION even though those patients didn’t have any...signs of neurological impairment...
Scientists disagree about whether SARSCoV2 is present in COVID-19 patients’ brains..."really looked hard for the virus’s presence, and we couldn’t find it..."
But previous work... has>
shown that bloodborne factors outside the brain can SIGNAL THROUGH the BLOOD-BRAIN BARRIER to ignite INFLAMMATORY RESPONSES INSIDE the BRAIN. This could explain why...factors in young mice’s blood can rejuvenate older mice’s cognitive performance, whereas blood from old mice can>
Read 31 tweets
I've seen your picture
Your name in lights above it
This is your big debut

Nano Drugs: Let The Blood-Brain Barrier No Longer Be A "Barrier" | Biochempeg…
Read 7 tweets
"Cytokine stimulation increased the binding capability of anti-S2 antibodies to human lung epithelial cells. Together, the upregulated expression of annexin A2 by SARS-associated cytokines and the cross-reactivity of anti-SARSCoV S2 antibodies>
Read 4 tweets
On #WorldBrainDay, the Neuronet programme is celebrating @IMI_JU's public-private partnerships in #neurodegeneration research; from fundamental science to clinical studies, data analysis to knowledge mining & beyond.

Keep your eyes peeled! #WeAreNeuronet
2/20 @bwfalcon, now a group leader at @MRC_LMB, worked on the structure of Tau filaments @imprind, showing how they are misfolded in the brains of people with #neurodegenerative diseases.

Read about his work here: #WorldBrainDay
3/20 #WorldBrainDay 2020 is dedicated to raising awareness of #Parkinsons disease. There are currently no disease-modifying treatments for mild cognitive impairment in PD; the #PD-MIND project aims to test a new drug to treat this condition. Find out
Read 21 tweets

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