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Edgar V. Lerma 🇵🇭
@edgarvlermamd
, 9 tweets, 10 min read Read on Twitter
FRANCIS: Hemolytic Uremic Syndrome
#NKFClinicals 🇺🇸 #Nephpearls
Clinical and laboratory manifestations of atypical HUS (aHUS)
#NKFClinicals 🇺🇸 #Nephpears
👉🏼 openurologyandnephrologyjournal.com/contents/volum…
Mimics of aHUS
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 sciencedirect.com/science/articl…
Evaluation of Thrombotic Microangiopathy (TMA)
#NKFClinicals 🇺🇸 #Nephpearls
The risk of post-transplant recurrence of aHUS depends on the underlying genetic abnormality‼️
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 ncbi.nlm.nih.gov/m/pubmed/24076…
PLASMIC Score: The key in TMA syndromes (including aHUS, TTP and Secondary TMA) is improving the rapidity of accurate diagnosis and early initiation of therapy ‼️
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 thelancet.com/pdfs/journals/…
GORDON: Diagnostic algorithm for the investigation and management of a patient presenting with thrombotic microangiopathy TMA
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 cjasn.asnjournals.org/content/clinja…
SIEDLECKI: Current concepts in mgmt. of aHUS
📌 Plasma exchange is reported in retrospective manner so difficult to compare w/ prospective trials
📌 Eculizumab treatment discontinuation is being considered more frequently in select low risk patients
#NKFClinicals 🇺🇸 #Nephpearls
Current concepts in management of aHUS
📌 Treatment guidelines for pregnancy remain limited but Eculizumab appears to be safe in this context
📌 Infectious prophylaxis should focus on encapsulated organisms incl. N. meningitides and S. pneumoniae
#NKFClinicals 🇺🇸 #Nephpearls
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