Thread by @PulmCrit

-for stable patient dont transfuse unless hemiglobin <7 (possibly 8 in acute coronary syndrome)
-give in single units to avoid overshoot

- platlet transfusion target of 10 in absence of bleeding
- avoid platelets in HITT and TTP
-Lissa Ajjamada at #HRmed19

- dose ffp around 3-5 units
- will never get normal INR!
- avoid FFP as prophylaxis before low-risk procedures
-Lissa Ajjamada at #HRmed19

cryo: fibrinogen targets depend on clinical context
-Lissa Ajjamada at #HRmed19

always give IV vitamin K with PCC!
-Lissa Ajjamada at #HRmed19

adnexanet still awaiting approval in canada. insanely expensive, may be problematic if approved
-Lissa Ajjamada at #HRmed19

- citrated tube to r/o pseudothrombocytopenia
- thought required: don’t just throw FFP at everything
-Lissa Ajjamada at #HRmed19

mixing study to differentiate factor inhibitor vs deficiency
-Lissa Ajjamada at #HRmed19

-INR isnt reflection of true overall coagulation in cirrhosis
-liver transplant surgeons may take pts to OR with INR of six!
-Lissa Ajjamada at #HRmed19

-nonemergent procedure: early IV vitamin K (dont give PCC!)
- newer formulations of IV vitamin K safer, lower risk of anaphylactoid rxn
-Lissa Ajjamada at #HRmed19

- DIC pt without active bleeding: treat cause.
- unless in APL (acute promyelocytic leukemia), little value in replacing factors
-Lissa Ajjamada at #HRmed19