There are so many more aminoglycosides than I ever thought 😅
AGs are characterized by concentration-dependent killing (high peak/MIC is desirable), the post-antibiotic effect, and synergism
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#IDtwitter #idmeded
Many many trials have shown once-daily dosing is = or superior to BID/TID in many different diseases/populations
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Synergy does not work for MRSA
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These enzymes are often carried on plasmids that also confer resistance to other drug classes
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Also AGs can induce biofilm formation, sooo...that might be concerning
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By contrast, ototoxicity is due to cumulative effects, so the same total daily dose has same risk, regardless of dosing pattern
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Gentamicin can be used as one-time injection into the middle ear to destroy hair cells and thus treat Meniere disease, controlling vertigo in 75% of patients! Pretty cool!
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