For studies with subjective endpoints, was the control really adequate.
amjmed.com/article/S0002-…
Always be cautious when surrogate endpoints are used.
thelancet.com/journals/lance…
Consider the “pre-study” probability that the treatment is effective.
jamanetwork.com/journals/jama/…
When the results of a trial only barely reach statistical significance, consider the fragility index.
jamanetwork.com/journals/jamas…
Remember that trials terminated early systematically overestimate the benefit of the intervention.
jamanetwork.com/journals/jama/…
Never forget about publication bias and p-hacking.
ncbi.nlm.nih.gov/pubmed/22853650
Always ponder generalizability. Your patient almost certainly would have been excluded from the trial you are reading. Is it OK to still apply the conclusions to your patient?
And, for #8, just seems like this needs to be cited…
journals.plos.org/plosmedicine/a…