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Thread: Questions we should be asking. Why are so many #SARSCoV2 studies focusing on humoral immunity & neutralizing antibodies when B-cell antibody production is not crucial to overcome #COVID19? It is the strong cytotoxic T-cell responses that bode well for long-term immunity.
2/ Antibody isotope in humoral immunity also matters. #SARSCoV2 antibody studies are only focusing on IgG which provides late #COVID19 protection in the lower airways: the lungs. It is secretory IgA in the nasal mucosa that provides early COVID-19 protection in the upper airways.
3/ Significant lack of discussion of latter: #SARSCoV2 vaccine candidates via intra-muscular injection would NOT confer IgA immunity. Successful #SARSCoV2 containment in upper resp tract requires IgA, not IgG. Leading vaccine candidates against #COVID19 do NOT elicit IgA prod’n.
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#SARSCoV2 #COVID19

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Kulvinder Kaur MD
@dockaurG
Based on published #HCQ studies & case-controlled clinical trials, HCQ has significant efficacy in early treatment of #COVID19: PRE-exposure prophylaxis & early POST-exposure treatment. Recent NEJM RCT focused on NEITHER of these 2 key groups but rather: POST-exposure prophylaxis
2/ Here’s link to NEJM #HCQ RCT published today on POST-exposure prophylaxis given up to 4d AFTER exposure. Disturbing that science was again politically sensationalized by media before study was even published w/quotes from MD with #Gilead #BigPharma COI
nejm.org/doi/full/10.10…
3/ “The results reported by Boulware et al. are more provocative than definitive, suggesting the potential prevention benefit(s) of #Hydroxychloroquine remain to be determined,” concluded Dr. Myron Cohen MD in NEJM editorial re recent NEJM HCQ #COVID19 RCT
nejm.org/doi/full/10.10…
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Kulvinder Kaur MD
@dockaurG
Imp Thread: public health fallacy to claim popn #SARSCoV2 IgG serology tests capture all pts recovered from #COVID19: grossly UNDERestimates % popn that was asymptomatic & recovered. Key arms of immune response to #SARSCoV2: humoral with antibodies & cell-mediated with T-cells
2/ Current public health method to estimate population immunity to #SARSCoV2 from recovered asymptomatic #COVID19 ppl uses serology tests to detect IgG antibodies: this only captures humoral immunity. Currently no widely available testing kit for T-cell immunity to #SARSCoV2
3/ Pts mount strong T-cell immune responses to #coronaviruses. Published Cell research & studies on recovered #COVID19 pts w/immunodeficiency disorders w/inability to mount B-cell responses to #SARSCoV2 reveal B-cell antibody responses not strictly required to overcome COVID-19
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Kulvinder Kaur MD
@dockaurG
1/2M living in ON don’t qualify for OHIP b/c they are not permanent residents or Cdn citizens: their “free” healthcare would cost ON taxpayers ~$2.5B/yr under NDP’s “sanctuary province” & $Billions/yr more from influx once ON opens borders for “free medical tourism”. 1/3

#onpoli
Why are none of these $BILLIONS needed to make ON a “sanctuary province” not costed in @OntarioNDP’s policy platform?

This will be a significant burden on our existing #ONHealth Crisis, esp as our senior pop’n is projected to grow by >68% over next 20yrs. 2/3

#onpoli #onelxn
These $Billions are in addition to $7Billion math mistake already found in NDP platform

Patient care in ON is already significantly rationed to pay our existing $1B/mth interest on ON’s massive $350B debt. I’m fearful for the future of #ONHealth 3/3

#onpoli #onelxn #carenotcuts
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