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13 Oct, 4 tweets, 3 min read
🚨BREAKING: huge clinical trial of Johnson & Johnson’s #coronavirus vaccine has been paused with enrollment of new participants stopped due to an "unexplained illness" in a study participant.

No details yet on the nature of the potential adverse reaction.
statnews.com/2020/10/12/joh…
This comes a month after a study of another #coronavirus vaccine by AstraZeneca and @UniofOxford was paused due to a suspected adverse reaction in a UK patient (transverse myelitis). The study resumed in the UK and other countries, but still NOT in the US.
The current pause in JNJ's trial was due to a pre-set “pausing rule” and now, an independent committee (not affiliated with the company) that watches over the safety of patients in the clinical trial will be convened to review all of the safety info.

Bottom line: there are NEVER any guarantees in #vaccine or drug development, especially with a brand-new virus.

This is why the FDA's career physicians and scientists, not Trump's political picks, should be the ones who decide whether or not a vaccine is safe and effective.

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More from @DrDenaGrayson

Dena Grayson, MD, PhD Profile picture
15 Oct
🚨BREAKING: on the same February day that Trump falsely claimed the #coronavirus was “very much under control,” aides told the Hoover Institution the #outbreak could prove worse than publicly revealed, giving wealthy donors an early warning to SELL OFF.🤬

nytimes.com/2020/10/14/us/…
Kudlow revealed the #coronavirus was “contained in the US to date, but now we just don’t know,” per a document from a hedge fund consultant who attended the briefings: “What struck me,” was that nearly every official raised the virus “as a point of concern, totally unprovoked.”🧐
"Interviews w/8 people who either received copies of the memo or were briefed on aspects of it...provide a glimpse of how elite traders had access to info from the administration that helped them gain financial advantage during a chaotic 3 days when global markets were teetering.
Read 8 tweets
Dena Grayson, MD, PhD Profile picture
14 Oct
‼️First #COVID19 death confirmed in a person *REINFECTED* with the #coronavirus.

Although other #SARSCoV2 reinfections have been confirmed, this is the 1st DEATH after reinfection known in the world.

<Thread>

#COVID19 #WearAMask
cnn.com/2020/10/13/eur…
The elderly woman had Waldenström's macroglobulinemia (rare blood cancer) & was receiving therapy to deplete B cells that make antibodies ("humoral immunity"). However, her T cells, which work to kill virus-infected cells (cell-mediated immunity), should NOT have been affected.🦠
The woman was initially admitted into hospital earlier this year with a severe cough + fever and tested positive for the #coronavirus. She was discharged 5 days later when "besides some persisting fatigue, her symptoms subsided completely."

#COVID19 #Reinfection
Read 11 tweets
Dena Grayson, MD, PhD Profile picture
13 Oct
🚨BREAKING: Eli @LillyPad's Phase 3 trial of its monoclonal antibody (mAb) treatment (in combination with #remdesivir) for #COVID19 has been paused after an independent data safety monitoring board (DSMB) noted "potential safety concerns."

#coronavirus
cnbc.com/2020/10/13/us-…
Lilly's mAb for #coronavirus is similar to @Regeneron's mAb cocktail (mixture of 2 mAb's) that Trump received for his #COVID19 and then falsely touted as a “cure.” Trump also touted Lilly’s treatment and others: “We have these drugs, Eli Lilly and the others that are so good.”
Such a "pause" in large clinical trials is not uncommon and may be due to a safety issue NOT related to the mAb (e.g., participant had a stroke). The *independent* (not beholden to the company) DSMB will review all of the safety data before any new participants are enrolled.
Read 4 tweets
Dena Grayson, MD, PhD Profile picture
12 Oct
Leon Black paid >$50 million to pedophile Jeffrey #Epstein AFTER his conviction.

“It was not clear what kind of ‘services’ #Epstein provided to Black, whose $9 billion fortune can buy him access to the best lawyers and accountants in the world.”🧐
nytimes.com/2020/10/12/bus…
Black’s payments included $10 million to a foundation started by #Epstein and “consulting” fees that were sufficiently unusual to draw scrutiny from Deutsche Bank(!), where #Epstein kept his accounts. The total amount sent by Black to Epstein could be as high as $75 million.🧐
#Epstein—a self-styled“financial doctor” to wealthy clients—was a college dropout who had worked on Wall Street for just a few years, had no great skill as an investor, and had no formal training in tax and estate planning.

Why would a billionaire keep paying him MILLIONS?🤢🤮
Read 4 tweets
Dena Grayson, MD, PhD Profile picture
9 Oct
‼️Trump's #TaxReturns reveal how he engineered a sudden financial windfall: >$21 million in "highly unusual" one-off payments from the Las Vegas hotel he owns with his casino-mogul friend, Phil Ruffin.

Smells like TAX FRAUD.🧐

#TaxFraudTrump #TaxFraud
nytimes.com/interactive/20…
Most of the $$ went thru a company called Trump Las Vegas Sales and Marketing: little previous income, no clear business purpose and ZERO employees.

The Trump-Ruffin venture wrote it off as a business expense.

This does NOT look like a legit "business expense."🧐

#TaxFraud
Why did Trump's company with ZERO employees have >$20 million in fees for the first time. And all of this money is going to a man who just happens to be running for president, might not have a lot of cash on hand, and NEEDED cash to float his campaign?🧐

#TaxFraudTrump
Read 6 tweets
Dena Grayson, MD, PhD Profile picture
8 Oct
🔥WHOA. In an unprecedented move, the editors of the prestigious New England Journal of Medicine condemn the Trump administration for its FAILED response to the #coronavirus pandemic.

And they call for @realDonaldTrump to be VOTED OUT.💥

@NEJM #COVID19
nejm.org/doi/full/10.10…
“The magnitude of this failure is astonishing. The US leads the world in #COVID19 cases and in deaths. The death rate in this country is more than double that of #Canada, exceeds that of #Japan, a country with a vulnerable and elderly population, by a factor of almost 50.”💥
We have FAILED at almost every step. We had ample warning, but when the disease 1st arrived, we were incapable of testing effectively & couldn’t provide even the most basic #PPE to health care workers and the general public. And we continue to be way behind the curve in testing.
Read 10 tweets

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