#ivermectin does not work.
1/Ther is more than meets the eye.
This paper was first sent 2 @FrontiersIn special issue
But issued a rejection after they identified “series of strong, unsupported claims” in paper as it "didnt offer an objective nor balanced scientific contribution
2/ Read the Chief Editor Frederick Fenter's media statement on the same blog.frontiersin.org/2021/03/02/2-m…
The paper made series of strong, unsupported claims based on studies with insufficient statistical significance, and at times, without the use of control groups. #COVID19
3/ Further, authors promoted their own specific #ivermectin treatment wich was inappropriate 4 a systematic review/metanalysis article. This paper does not follow @PRISMAStatement guidelines prisma-statement.org
Authors missed astute risk of bias/heterogeinity assessments
4/ Authors reviewed pooled metanalysis frm their own biased website that does not consider proper inclusions and exclusion. There is no PRISMA flow study followed. It is a TERRIBLE paper. They incluced observational trials along with RCTs to prove a point. Thats just bad science.
5/ These are elements required for metanalysis/syst review prisma-statement.org/documents/PRIS…
C hw much they screwed up in methodology. There is NO: search strategy/selection process/data collection steps/risk of bias assesment/systhesis methods/reporting bias/certainity assesment
Pathetic.
5/ the-scientist.com/news-opinion/f…
This is actually #ivermectincult FLCCC's own webpage based 'reviews' of studies wich included PREPRINTS with lot of bias/risks for inclusion into a good meta-analysis. Meta-analysis is as gud as the studies included. This 1 FAILS by a LONG margin.
6/ Bcoz they didnt hav any better options as FLCCC group know that its a biased paper, AJT ultimately tuk it, for brownie points on citation. Only a matter of time, wen a letter to editor/proper critique will send this to hell. @ronaklmno@pash22@GorwayGlobal@Neurophysik
You can actually see how insecure the FLCCC is becoz they did not waste anytime in putting up this 'accepted article' all over their website and social media handles and news - for them to get the required (false) credibility. They R just a bunch of glorified cultist #quacks.
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I challenge ur narrative tat alternative medicine works
It doesnt/#neem studies tat u keep quoting, are NOT peer-reviewed, NOT published/has been collecting dust in preprint server since Apr 2020
Tis makes ur argument invalid
But #science is kind, so lets discus #MedTwitter
2 indiarxiv.org/pyqx4/ This is UR molecular docking study u uploaded to preprint. Y was this never published? Bcoz this is highly flawed from methods to results to conclusions. Molecular docking was blind - hence ligand optimization is not accurate... #ayush
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...and grid coordinates wer computer generated. Hw did u correct for tis? U cud hav used predicted binding sites 2 improve accuracy/efficiency ncbi.nlm.nih.gov/pmc/articles/P…
Predicted binding sites 4 #SARSCoV2 is widely published/ use of grid-based docking wud be better...
2/5 'Hypothesis' #Covid19 promot defective glucose metabolism (shown in controversial study pubmed.ncbi.nlm.nih.gov/32697943/) never clinically proven tho. Low-glucose mimetic (2DG) reduces tis, wit additional anti inflammatory/interaction wit viral proteins - again, cell study #MedTwitter
3/5 The anti-inflammatory/antiviral effect is thot 2 B due to glucose switching of 2GD - reversal of aerobic glycolysis to oxidative phosphorylation - is also in-silico study - not comprehensively shown in cell models. tandfonline.com/doi/full/10.10… @drreddys jumped the gun quickly.
Hello doctor. You can answer 2 ur own tweets.
Y call your non-medical friends? U hav been tweeting utter nonsense, polypharmacy 4 treatment of #COVID19India against all evidence based pooled data and analysis. Answer to why you want to use anti-depressants, diuretics and NSAIDs?!
You have tagged ICMR, when they dont recommend any drugs for 'variants' as your treatment suggest. U have tagged PMO India! That's intense, but he's MIA. What will Yogi Bisht, UP-CM discuss wit regards to covid protocol? He's busy arranging oximeters 4cows. U might hav read news
Also read more on the FLCCC alliance crap. The @NIH clearly recommend against #ivermectin use and these maverick groups are wasting everyone's time. Two handles you tagged are from these pariah medical groups - BIRD and FLCCC. That's not very credible. medpagetoday.com/infectiousdise…
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He goes 2 a GP. Clinical examination and blood tests done. Says some chest infection. Puts him on antibiotics for a week. Asks for review. 1wk later some change in symptoms, but not fully ok. GP extends antibiotic course 7 more days. C, no fever and no signs of infection yet.
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After 14d course, no change. Patient chucks the GP. Goes for a senior GP. Senior GP does clinical exam,blood tests AND chest X ray. X ray comes back as "not looking normal" 🙄 But no diagnosis. So he says. Let's try a short course of #antibiotics AND antifungal. Again 14 days
24 yr male - overweight by 11kg. Routine check up - fatty liver/advised by GP 2 stop eating - yes he said stop eating, eat when hungry or he'll develop cirrhosis + #MedTwitter#livertwitter
2/ So the guy gets food phobia - loses 2 much weight in 2 months - close to 12 kg - rechecks liver test - AST and ALT enzymes are higher than before - fellow is sure its 2 late and he is going to develop cirrhosis - so he goes 2 a Gastroenterologist at a suburban clinic + #ethics
3/ Gastro doc does his ultrasound liver - sees grade 3 fatty liver frm prev Grade 1 - says its bad (on radiological assessment). Liver tests show AST 200 ALT 102. Patient repeatedly asks if he had developed cirrhosis
No answer (a silent doctor is either a fool or thinking one) +
1/ My comments: #quackery is diff frm #pseudoscience
Former may hav secular/political or religious attributes while the latter does hav regional differencs wit respect 2 political/religious practices
Some eg, discuss:
Traditional Chinese Med
Japanese Kampo
Homeopathy
Ayurveda
2/ "A quack is a "fraudulent or ignorant pretender to medical skill" or "a person who pretends, professionally or publicly, to have skill, knowledge, qualification or credentials they do not possess; a charlatan or snake oil salesman".
3/ "Pseudoscience consists of statements, beliefs, or practices that claim to be both scientific and factual but are incompatible with the scientific method". #pseudoscience may or may not lead to quackery
Eg i-red.in zyropathy.com