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TheLiverDoc Profile picture
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8 May, 6 tweets, 4 min read
1/5
 Whole premise of #2deoxy2glucose is based on this SINGLE computational proteomics study nature.com/articles/s4158…
No human trials until nw
1 of 'targets' hypothesized in reviews nature.com/articles/s4225…
Last human trials on this molecule is from 1982-2007
@drcheruvarun @pash22
2/5
 'Hypothesis' #Covid19 promot defective glucose metabolism (shown in controversial study pubmed.ncbi.nlm.nih.gov/32697943/) never clinically proven tho. Low-glucose mimetic (2DG) reduces tis, wit additional anti inflammatory/interaction wit viral proteins - again, cell study
#MedTwitter
3/5
 The anti-inflammatory/antiviral effect is thot 2 B due to glucose switching of 2GD - reversal of aerobic glycolysis to oxidative phosphorylation - is also in-silico study - not comprehensively shown in cell models.
tandfonline.com/doi/full/10.10…
@drreddys jumped the gun quickly.
4/5
 But the dose of 2DG required, daily administration may cause non-target effects in the form of brain disturbances and cardio-respiratory side effects
AND 2DG is better wen used wit low dose radiation therapy (LDRT)
BUT LDRT is found useless in #covid pubmed.ncbi.nlm.nih.gov/33957219/
5/5
 Optimum 2DG dose shud B administered soon after infection + 2 enhance efficacy LDRT for #COVID19India pneumonia - as per hypothetical reviews
So timing/dose/add on LDRT all matter which is MISSING in this protocol
This 'adjuvant' is another money making business if U ask me.

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More from @drabbyphilips

TheLiverDoc Profile picture
9 May
1
I challenge ur narrative tat alternative medicine works
It doesnt/#neem studies tat u keep quoting, are NOT peer-reviewed, NOT published/has been collecting dust in preprint server since Apr 2020
Tis makes ur argument invalid
But #science is kind, so lets discus
#MedTwitter
2
indiarxiv.org/pyqx4/ This is UR molecular docking study u uploaded to preprint. Y was this never published? Bcoz this is highly flawed from methods to results to conclusions. Molecular docking was blind - hence ligand optimization is not accurate...
#ayush
3
...and grid coordinates wer computer generated. Hw did u correct for tis? U cud hav used predicted binding sites 2 improve accuracy/efficiency
ncbi.nlm.nih.gov/pmc/articles/P…
Predicted binding sites 4 #SARSCoV2 is widely published/ use of grid-based docking wud be better...
Read 14 tweets
TheLiverDoc Profile picture
8 May
#ivermectin does not work.
1/Ther is more than meets the eye.
This paper was first sent 2 @FrontiersIn special issue
But issued a rejection after they identified “series of strong, unsupported claims” in paper as it "didnt offer an objective nor balanced scientific contribution
2/
 Read the Chief Editor Frederick Fenter's media statement on the same
blog.frontiersin.org/2021/03/02/2-m…
The paper made series of strong, unsupported claims based on studies with insufficient statistical significance, and at times, without the use of control groups.
#COVID19
3/
 Further, authors promoted their own specific #ivermectin treatment wich was inappropriate 4 a systematic review/metanalysis article. This paper does not follow @PRISMAStatement guidelines prisma-statement.org
Authors missed astute risk of bias/heterogeinity assessments
Read 9 tweets
TheLiverDoc Profile picture
7 May
Hello doctor. You can answer 2 ur own tweets.
Y call your non-medical friends? U hav been tweeting utter nonsense, polypharmacy 4 treatment of #COVID19India against all evidence based pooled data and analysis. Answer to why you want to use anti-depressants, diuretics and NSAIDs?!
You have tagged ICMR, when they dont recommend any drugs for 'variants' as your treatment suggest. U have tagged PMO India! That's intense, but he's MIA. What will Yogi Bisht, UP-CM discuss wit regards to covid protocol? He's busy arranging oximeters 4cows. U might hav read news
Also read more on the FLCCC alliance crap. The @NIH clearly recommend against #ivermectin use and these maverick groups are wasting everyone's time. Two handles you tagged are from these pariah medical groups - BIRD and FLCCC. That's not very credible.
medpagetoday.com/infectiousdise…
Read 5 tweets
TheLiverDoc Profile picture
16 Mar
1
Listen to this story of #tuberculosis
Real, not fiction. Even though may sound like super fiction. Of a patient now admitted under me.

56 yr man. Prior #smoker No #alcohol use, no #DRUGS. Family guy. Starts havin cough. Nagging no sputum
Keeps him awake at night
#MedTwitter
2
He goes 2 a GP. Clinical examination and blood tests done. Says some chest infection. Puts him on antibiotics for a week. Asks for review. 1wk later some change in symptoms, but not fully ok. GP extends antibiotic course 7 more days. C, no fever and no signs of infection yet.
3
After 14d course, no change. Patient chucks the GP. Goes for a senior GP. Senior GP does clinical exam,blood tests AND chest X ray. X ray comes back as "not looking normal" 🙄 But no diagnosis. So he says. Let's try a short course of #antibiotics AND antifungal. Again 14 days
Read 18 tweets
TheLiverDoc Profile picture
16 Mar
1/
 A real story of #modern medicine & #Ayush

Sad wen the former messes things up

24 yr male - overweight by 11kg. Routine check up - fatty liver/advised by GP 2 stop eating - yes he said stop eating, eat when hungry or he'll develop cirrhosis +
#MedTwitter #livertwitter
2/
 So the guy gets food phobia - loses 2 much weight in 2 months - close to 12 kg - rechecks liver test - AST and ALT enzymes are higher than before - fellow is sure its 2 late and he is going to develop cirrhosis - so he goes 2 a Gastroenterologist at a suburban clinic +
#ethics
3/
 Gastro doc does his ultrasound liver - sees grade 3 fatty liver frm prev Grade 1 - says its bad (on radiological assessment). Liver tests show AST 200 ALT 102. Patient repeatedly asks if he had developed cirrhosis
No answer (a silent doctor is either a fool or thinking one) +
Read 14 tweets
TheLiverDoc Profile picture
15 Mar
1/
 My comments:
#quackery is diff frm #pseudoscience
Former may hav secular/political or religious attributes while the latter does hav regional differencs wit respect 2 political/religious practices
Some eg, discuss:
Traditional Chinese Med
Japanese Kampo
Homeopathy
Ayurveda
2/
 "A quack is a "fraudulent or ignorant pretender to medical skill" or "a person who pretends, professionally or publicly, to have skill, knowledge, qualification or credentials they do not possess; a charlatan or snake oil salesman".
3/
 "Pseudoscience consists of statements, beliefs, or practices that claim to be both scientific and factual but are incompatible with the scientific method".
#pseudoscience may or may not lead to quackery
Eg
i-red.in
zyropathy.com
Read 6 tweets

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