100 years ago, #insulin was discovered—today, it is inaccessible for millions.

The Lancet journals reflect on this life-saving treatment and the "golden opportunity to improve access to insulin and #diabetes care" the centenary represents: hubs.li/H0Rp3p40 #Insulin100⬇️ Quote: 100 years after its discovery, insulin should be acce
The discovery of insulin ranks among the leading triumphs of medical research, with effects on #endocrinology, #medicine, and society that reverberate 100 years later.

Track "the birth of an idea" in @TheLancetEndo, by Robert Hegele and Grant Maltman: hubs.li/H0Rbx1D0
Although insulin has changed the lives of countless people with #diabetes, writes David Beran et al, the time for celebration has not yet arrived due to the absence of concrete action on #insulin access.

Read the Comment in @TheLancetEndo: hubs.li/H0QMPY00 #Insulin100 Quote: We need to be blunt—urgent action is required to ad
In 2019, 463 million people had diabetes. Poor access to life-saving technologies, such as #insulin, has resulted in acute emergencies and avoidable deaths.

The #LancetDiabetes Commission discusses the barriers to insulin access globally: hubs.li/H0QMLlt0 #Insulin100
To act on the growing epidemic of disease, death, and inadequate patient care in diabetes, @WHO has launched the Global Diabetes Compact.

Daniel Hunt et al. discuss the components of the new initiative, including widening access to #insulin: hubs.li/H0QMNm-0 #Insulin100
Browse historical articles, commissions, multimedia, and more content on closing the gap on global #insulin access on our new hub—100 years of insulin ➡️ hubs.li/H0Rp3p40 #Insulin100

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More from @TheLancet

20 Jun
There are some 26.3 million refugees worldwide today.

On #WorldRefugeeDay, the Lancet journals highlight the health insecurity and inequities refugees face, exacerbated by the #COVID19 pandemic ⬇️

#WithRefugees
Applications for asylum and resettlement disrupted, blamed for spreading #COVID19, and inequitable #vaccine access.

Under the 1951 Refugee Convention, refugees are entitled to certain protections—our Editorial questions whether these are being upheld. hubs.li/H0QDCzT0
Failure to address migrant and refugee health as an essential component of health systems leaves everyone at greater risk of severe health, economic and social impacts when the next pandemic strikes.

Read the Commentary in @EClinicalMed: hubs.li/H0QDCwy0 #WorldRefugeeDay
Read 5 tweets
5 Jun
On this day, in 1981, 5 cases of what came to be known as AIDS, were reported in @CDCMMWR—changing the world.

Today, the Lancet journals reflect on the science and people behind #40YearsOfHIV/AIDS response through a special collection of content ➡️ hubs.li/H0PGLbC0
Months later, Kenneth Hymes et al. published an article in @TheLancet describing Kaposi's sarcoma in a group of young homosexual men in New York, suggesting a sexually transmissible disease might have a role in the pathogenesis of the rare cancer.

Read hubs.li/H0PGMwN0.
In 1984, Philippe Van De Perre et al. and Peter Piot et al. provided early data on #AIDS in Rwanda and Zaire.

Udani Samarasekera talks to Peter, Director of @LSHTM, about the first African research project on AIDS, @UNAIDS, and hopes for the future: hubs.li/H0PGL9f0
Read 7 tweets
29 May
#ChronicPain affects over 30% of people worldwide and exerts an enormous personal and economic burden.

A new @TheLancet Series on #ChronicPain presents recent findings across specialties, with implications for health care providers and patients: hubs.li/H0PgfvK0

Thread⬇️
The Series explores 3 types of pain—nociceptive, neuropathic, nociplastic—and the biopsychosocial model of pain—interactions between #chronicpain, biological, psychological, and social factors.

Read an update on burden, best practices, and new advances: hubs.li/H0Pgfv10
Nociplastic pain is a new descriptor of pain arising from abnormal pain signal processing. It applies to a range of conditions, such as fibromyalgia, that lack clear mechanisms or biomarkers—a challenge to diagnose and treat.

Learn more ➡️ hubs.li/H0Pgfv30
Read 6 tweets
28 May
In 2019, the no. of smokers worldwide ⬆️ to 1.1 billion. Tobacco smoking caused ~8 million deaths—1 in 5 male deaths.

#GBD studies of 204 countries highlight the enormous health toll of 🚬 and authors urge all countries to do more to ⬇️ tobacco use. See hubs.ly/H0Pd0590.
89% of smokers began by age 25—evidence suggests an individual is unlikely to become a smoker if they do not start by this age.

Yet over half of countries show no progress in reducing 🚬 among 15-24-year-olds—a critical window to prevent initiation. Read hubs.li/H0Pd09f0.
Why have 🚬 control policies had little impact on young people? They may respond to policies in different ways to adults, writes @aekunst in @TheLancetPH. The solution? Centralising young people's perspectives and experiences. Read hubs.li/H0Pd0YM0.
Read 7 tweets
18 May
NEW—Emerging evidence indicates #COVID19 has distinctive pathophysiological features that set the disease apart from respiratory failure of other origins.

A new 4-part Series in @LancetRespirMed explores COVID-19: Pathophysiology of Acute Disease: hubs.li/H0NyR540
.@osuchm et al. provide a comprehensive Review of the pathophysiology and phenotypes of #COVID19. Read in @LancetRespirMed: hubs.li/H0NySMY0.
The challenges and promise of therapeutically targeting the pleiotropic cytokine interleukin-6 are considered in the 2nd & 3rd papers.

#Interleukin-6: obstacles to targeting a complex cytokine in critical illness—Oliver McElvaney et al: hubs.li/H0NyRjW0 (1/2)
Read 5 tweets
17 May
Cardiovascular disease is responsible for 35% of deaths in women yearly—yet remains:
❣️Understudied
❣️Under-recognised
❣️Underdiagnosed
❣️Undertreated

NEW @TheLancet Commission outlines 10 recommendations to improve health outcomes for millions of women: hubs.li/H0Ns28Y0
275 million women were diagnosed with cardiovascular disease (CVD) in 2019. Acknowledging sex and gender-specific risk factors is the key to understanding #CVD in women and reducing the 🌍 burden.

Read the #LancetWomenCVD Commission: hubs.li/H0Ns28Y0
The global prevalence of cardiovascular disease in women has declined by 4.3% since 1990, but has risen in some of the world's most populated nations—🇨🇳(10%), 🇮🇩(7%), 🇮🇳(3%).

@TheLancet #LancetWomenCVD Commission provides regional recommendations: hubs.li/H0Ns28Y0
Read 5 tweets

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