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Harriet Carroll: To be decided... Profile picture
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17 Dec, 4 tweets, 2 min read
nice article about pilot studies:
ncbi.nlm.nih.gov/labs/pmc/artic…

i think a lot of people see pilot studies as "mini" studies, but this can be misleading.

tl;dr: pilot studies primarily test study feasibility; they do NOT *test* hypotheses

#AcademicTwitter #research #Science
key aims of a pilot study include (depending on the study):
☑️checking the feasibility of the protocol
☑️work out finer details (e.g. dosage, type of placebo/control)
☑️assess randomisation/blinding/etc procedures
☑️refine participant-facing documentation (e.g. consent form, information sheet, etc)
☑️refine study-related documentation (etc) (e.g. finding data entry issues)
☑️understand likely drop-out/retention
what a pilot is not really designed to do:
❎calculate power (though they may offer useful insight, such as which outcome should be the focus)
❎justify foregoing a full trial if results are significant
❎testing a hypothesis

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Harriet Carroll: To be decided... Profile picture
17 Dec
#Antivax narratives actively harm the voices of the legit vaccine injured.

Antivaxxers fuel fear, take stories out of context, and encourage others to not get vaccinated. this means the vaccine injured (who may not be able to get boosters) are now less protected by herd immunity
There is a cruel irony that antivaxxers often shout about side effects being hidden, but they are the ones driving some of the silence. When a study comes out (e.g. the viral vector blood clots) and...
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Harriet Carroll: To be decided... Profile picture
17 Dec
something #academics i think dont want to admit when it comes to marking #student work:
you quite often just *know* what the mark is & this seems to be quite reliable between markers
no amount of rubrics can define this & often these trap markers into box-ticking
#AcademicTwitter
would you agree?

i hate having to justify my mark based on a rubric; it is usually obvious who is a upper/middle/lower 1st, 2:1, 2:2, 3rd, or fail.

obvs the issue is bias without something "objective" but...
...i don't think the objectivity line helps as we just end up fitting our mark into the rubric rather than letting the rubric define the mark
Read 6 tweets
Harriet Carroll: To be decided... Profile picture
19 Nov
something i think doctors don't always appreciate:
diagnoses are important to patients, even if there's no treatment

🧵

#MedTwitter #chronicillness #DisabilityRights
im sure there's other reasons but key things overall i think are:
1. a diagnosis gives you limits - what treatment can and can't be tried, what can trigger things, what's the prognosis, etc
2. it gives patients a community - there's tonnes of groups for people with all kinds of ailments, conditions, illnesses, disabilities. being able to talk to someone with a shared experience helps make everything less shit
Read 12 tweets
Harriet Carroll: To be decided... Profile picture
18 Nov
As some of you know im suffering weird #neurological symptoms atm. The last week has been pretty awful. One of the weirder symptoms is called micrographia: writing getting smaller and smaller.
↙️ My writing on Tuesday (bad not awful day)
My writing on Wednesday (awful day) ↘️ The words: corporate → research & development Location: coThe words: brief [blanked out] on extension Written in small
Micrographia in itself *can* be an early sign of conditions like #Parkinsons

In patients with Parkinsons, closing their eyes whilst writing can often help mitigate micrographia
(in my case the rapid onset followed by rapid improvement makes me think / hope its just whatever the fuck is going on with my neuro-immunology not a sign of whats to come...😬)
Read 5 tweets
Harriet Carroll: To be decided... Profile picture
7 Dec 20
during my #PhD, i conducted a side project investigating what the barriers are towards making changes to the #academicpublishing system to reduce publication #bias

journals.plos.org/plosone/articl…

this showed me a rather dark side to #academia... 1/8

#AcademicTwitter #phdlife
i got about 50:50 praise and hate for this. weirdly enough, the praise and hate were often about the same thing: the (early) stage of my career.

praise: "it's great you're so keen and have grasped key issues and taken action so early..." 2/8
hate: "you're too early in your career and naïve to understand these issues. you shouldn't be researching this"

more worryingly, whilst i did get a lot of this feedback in person/by email, some of it was BEHIND MY BACK to my colleagues 3/8
Read 10 tweets
Harriet Carroll: To be decided... Profile picture
11 Nov 20
ok i've used R now for about 10 hours so im definitely suitably enough experienced to say i hate it, its a big pile of shit, i dont know why this is what is popular, and i wish i had access to stata again. WAHHHHH
im sure people can tell me a million reasons why R is great. sorry to say: YOU'RE WRONG.
i will delete these tweets in a few weeks when it finally clicks and i think R is brilliant like everyone else does
Read 6 tweets

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