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Raj Rajnarayanan Profile picture
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Apr 29 • 4 tweets • 4 min read
#OmicronUpdates #NewLineagesAlert

BA.2.35 alias of B.1.1.529.2.35 | Prevalent in #Portugal

Key mutations: S:L452R & N:221F

PANGO issues: #554 | github.com/cov-lineages/p… Image
Cov-spectrum prediction: BA.2.35 has 39% growth advantage over BA.2 and ~95% over BA.1.1 in #Portugal (in the recent 3 month period)

Currently spotted in #Portugal, #UnitedKingdom, #USA, #Austria, #France, #Denmark and #Spain Image
Cov-spectrum link to follow this lineage: cov-spectrum.org/explore/Portug…
Presence of Spike L452R mutation makes it an important lineage to follow over time.

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More from @RajlabN

Raj Rajnarayanan Profile picture
May 2
Tracking #BA4 and #BA5 #Omicron #Sublineages over time

This tracker includes only sequences with signature mutations👇

Tracker: public.tableau.com/app/profile/ra…

Updated 5/02/2022
Tracking #BA4/#BA5 in #Europe ImageImage
Tracking #BA4/#BA5 in #USA Image
Read 5 tweets
Raj Rajnarayanan Profile picture
May 2
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

24.63% BA.2.12.1, <- Spike:L452Q
17.54% BA.2,
14.93% BA.2.9,
12.00% BA.2.12,
11.38% BA.2.10,
9.55% BA.2.3, and
2.35% BA.1.1

Tracker (by State): tinyurl.com/mryj4uu7

#OmicronUpdates 05/01/22
#OmicronVariantUpdates #UnitedStates 05/01/22

Top circulating #sublineages: BA.2.12.1, BA.2*, BA.2.9, BA.2.12, BA.2.10, BA.2.3, and BA.1.1

* includes recently designated BA.2.x.y Image
BA.2.12.1 Spike #L452Q #Hotspots - #USA

#NorthCarolina
#NewYork Image
Read 5 tweets
Raj Rajnarayanan Profile picture
May 1
Tracking #BA4 and #BA5 #Omicron #Sublineages over time

This tracker includes only sequences with signature mutations👇

Tracker: public.tableau.com/app/profile/ra…

Updated 5/01/2022
Tracking #BA4 and #BA5 in #NorthAmerica Image
This tracker doesn't include a suspected BA.4 sequence from #Maryland

Reason: #Amplicon #Dropout in the key region containing signature spike aa 452/486 which partly defines this lineage. Image
Read 6 tweets
Raj Rajnarayanan Profile picture
May 1
BA.2.12.1 is the top circulating lineage in the #UnitedStates

It has significant growth advantage over other circulating lineages in #USA

Cov-spectrum predicts a 47% growth advantage over BA.2* (over last three months)

Get #Boosted and #MaskUp! Image
Tracking Spike #L452Q mutation over time

Current Hotspot: #USA
Emerging Hotspot: #Canada

Tracker: public.tableau.com/app/profile/ra… Image
Tracking the rise of Spike L452Q mutation in #Canada

Hotspots: #BritishColumbia, #Alberta

Note: Many BA.2.12 (534 sequences) with Spike L452Q & Spike S704L (should have been designated as BA.2.12.1) Image
Read 8 tweets
Raj Rajnarayanan Profile picture
Apr 30
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

23.39% BA.2.12.1, <- Spike:L452Q
19.16% BA.2,
14.85% BA.2.9,
12.25% BA.2.10,
10.79% BA.2.12,
9.43% BA.2.3 and
2.33% BA.1.1

Tracker (by State): tinyurl.com/mryj4uu7

#OmicronUpdates 04/30/22
#OmicronVariantUpdates #UnitedStates 04/30/22

Top circulating #sublineages: BA.2.12.1, BA.2*, BA.2.9, BA.2.10, BA.2.12, BA.2.3, and BA.1.1

* includes recently designated BA.2.x.y Image
Sequence count by Division - #UnitedStates 04/30/22

#NewYork, #NorthCarolina, #Arizona, #California and #Connecticut have submitted >125 sequences with sample collection dates between April 15 to April 30, 2022. Image
Read 8 tweets
Raj Rajnarayanan Profile picture
Apr 30
To BA.4 or not to... that is the real question!

BA.4 signature -

From PANGO issue #517 (#silcn): N:P151S, L452R, F486V (@CorneliusRoemer's query BA.2* + 12160A, 9866., 27788T)

From @Tuliodna - N:P151S, NS7b: L11F, NSP1 141-143del

There is overlap but missing many.. Image
@siamosolocani @Gab_H_R @sigallab @PeacockFlu @TWenseleers @DrEricDing @EricTopol @Mike_Honey_ @kallmemeg @VincentRK @Rajeev_The_King @rid1tweets @DGBassani @trvrb @nicd_sa
Here's @Tuliodna's tweet

Read 8 tweets

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