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As promised, here is a #tweetorial on spatially-fractionated radiotherapy aka Lattice aka GRID.

If you missed the #CTOS2019 talk by @Notorious_RBE, this one is for you!
Spatial fractionation aims to intentionally deliver heterogeneous dose: alternating “hot” and “cold” areas with a differential of 30-100% Rx.

Thats right: you want 30% cold spots in tumor. (👇 #MedPhys reaction).
It seems crazy, but it is associated with excellent response and limited toxicity. Per reports. That are retrospective.

Dramatic response in rads refractory sarcoma: link.springer.com/article/10.100…

Case series of 71 palliative patients: ncbi.nlm.nih.gov/pubmed/1052442…
Read 14 tweets
Part II of today’s tweetorial for International clinical trials day: #CTD2019 #ICTD2019

Why do you want to give physicists a central role in your radiotherapy trials?



#medphys #radonc
@ipemnews @EFOMP_org @aapmHQ @EORTC @CTRad_CChan
First, what characterises medical physicists?
- We're quantitative, systematic & analytical
- We're trained in modelling, data visualisation, & interpretation of evidence

(And sometimes we - by which I mean me - go exploring in caves, which is almost like running a trial 😅)
But importantly, we understand the opportunities and limitations in current technology & are uniquely placed to understand current gaps in knowledge.

We can ask

“How can we best utilise technology to improve outcomes?”
“Will this be achievable in daily practice?”
Read 22 tweets
Today is International Clinical Trials Day! #CTD2019

In the spirit of #CTD2019, I thought I’d take a bit of time to talk about medical physicists and radiotherapy trials #medphys #radonc
@ipemnews @EFOMP_org @aapmHQ
Why should radiotherapy trialists care about medical physicists? And why should physicists involve themselves in trials?
The short answer: It makes trials a whole lot better!

The slightly longer answer: It ensures maximum value from data that we are entrusted by patients

And the properly detailed answer will take a couple of tweetorials ☺️
Read 14 tweets

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