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This is pretty wild, looking at the paper now, but they took gut bacteria from (human) schizophrenic folks and non-schizophrenic controls and put it into germ free mice. The mice with the scz bacteria had changes in behavior and CHANGES in the glutamate modulation in the brain.
H/T @mostrolenk here is a write up of the findings... newatlas.com/schizophrenia-…
"Compared to HCs, germ free mice receiving SCZ microbiome fecal transplants had lower gluamate and higher glutamine and GABA in the hippocampus and displayed SCZ-relevant behaviors similar to other mouse models of SCZ involving glutamatergic hypofunction...
"...findings suggest that the SCZ microbiome itself can alter neurochemistry and neurologic function in ways that may be relevant to SCZ pathology."
It's always prudent not to get too excited about mouse studies, but, keep your ear to the ground about this sort of thing for sure. Minocycline is an antibiotic with growing evidence for use in psychosis. ncbi.nlm.nih.gov/pmc/articles/P…
Minocycline's mechanism of action is usually discussed as "anti-inflammatory in the brain" but maybe some of the way it does that is by taking out some pathogens in the gut? This is just speculation...
Also wanted to add the microbiome paper is in a Science franchise, iow The Big Time, not like West Springfield Gut Physiology and Anthropology Journal
And I haven’t had a chance to finish the entire paper but it’s 2019 and we need metabolomics in every useful microbiome paper, not just taxonomy baby, and this paper did them. Woot!
#metabolomics this paragraph!!!!! (yes Vanilla is helping me review) 
