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Talal Hilal
@THilalMD
, 15 tweets, 5 min read Read on Twitter
My only #ASCO19 Tweets will be in this thread. I will post a few abstracts of negative trials with and without positive spin. Things not to do as of June 2019.
This is somewhat obvious, but in case you didn't know, do not give rituximab maintenance for DLBCL. meetinglibrary.asco.org/record/174772/…
Despite these deceptive conclusions, do not use pembrolizumab in
HCC in the second-line setting. meetinglibrary.asco.org/record/173190/…
Do not get overly excited about a PFS endpoint in a lethal disease like pancreatic cancer meetinglibrary.asco.org/record/174488/…
When you have a patient with advanced soft tissue sarcoma, do not give them olaratumab. meetinglibrary.asco.org/record/174690/…
Don't blast patients with metastatic colorectal cancer with FOLFOXIRI + bev because of a 3 month median PFS difference, and no OS difference. meetinglibrary.asco.org/record/171164/…
Don't add abiraterone to enzalutamide in metastatic CRPC. More is not better in this case. meetinglibrary.asco.org/record/172903/…
There is no need to give patients with metastatic CRPC diarrhea by giving them 2 grams of metformin when they will be getting docetaxel for their cancer. meetinglibrary.asco.org/record/172957/…
Again, despite deceptive conclusions, pembrolizumab +chemo is not superior to EXTREME regimen in overall population of metastatic head and neck cancer, specifically in CPS 0%. meetinglibrary.asco.org/record/171051/…
More regimens trying to beat EXTREME but failing. Docetaxel, cisplatin, cetuximab + maintenance cetuximab is not superior to EXTREME. Do not conclude equivalence in a superiority trial. meetinglibrary.asco.org/record/171046/…
If you come across some more informative negative trials please reply to this thread..
Can we call this a negative trial? Or maybe a positive trial that is not so positive for patients.
Let me add a few more.

Durvalumab +/- tremelimumab in second-line metastatic head and neck cancer not better than SOC chemo (including methotrexate!). Do not use durvalumab. meetinglibrary.asco.org/record/175441/…
Interesting study in adjuvant non-squamous NSCLC where pemetrexed/cisplatin not proven to be superior to vinorelbine/cisplatin. meetinglibrary.asco.org/record/173488/…
Pazopanib/gemcitabine in second-line metastatic STS not superior to SOC gemcitabine/docetaxel. meetinglibrary.asco.org/record/175014/…
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Talal Hilal
@THilalMD
Let's talk broad concepts - Causality. #thread
Suppose Jack took LSD and then got into a car accident. Did the LSD cause the car accident?
In a parallel universe where Jack did not take the LSD:
- If he gets into a car accident, then the LSD was probably incidental
- If he does not get into a car accident, then the LSD was probably the cause

That's a counterfactual view of causality.
Read 19 tweets
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Talal Hilal
@THilalMD
Why the confidence interval (CI) is very useful. #thread #epistats
Hypothesis testing involves estimating the probability that an observed result would have occurred by chance if the null hypothesis were true.
There are limitations to hypothesis testing:
1- Viewing outcomes as dichotomous (yes/no) rather than viewing them as a continuum
2- Choosing a single cut point for “rejecting” the null hypothesis when that choice is often arbitrary
Read 17 tweets
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Talal Hilal
@THilalMD
Our viewpoint JUST OUT in @NatRevClinOncol on the role (or lack thereof) of blinatumomab for B-ALL in complete remission #leusm nature.com/articles/s4157…
We present 4 points to think about when considering the use of blinatumomab for B-ALL in CR. I have a feeling Vinay Prasad (@PlenarySessShow), may have a few things to say about it. nature.com/articles/s4157…
1/ the methods of MRD testing are not universally agreed upon and have variable sensitivities. What is sometimes considered "negative" by one method may not be "negative" by another. bloodjournal.org/content/125/26…
Read 9 tweets

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Esther Bartkiw
@soul_whispers
June New Moon Report ➡️ happening Monday the 3rd at 6:02 am eastern time in the sign of Gemini and the energetics support communications, socialization and strong intuitive hits PLUS gives us a foreshadowing of what may be coming up during the July 2nd Solar Eclipse New Moon
2. ...Let's break it down.
New Moon energies are ripe with the perfect frequencies to facilitate new beginnings and fresh starts. Because the moon is transiting the Gemini part of the sky all Gemini themes are highlighted for boosts and NEW all month long leading up to
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Dr Luttapi
@Mayavi101
From a neck to neck race to one sided contest in just a few months. From Rahul rising & Modi dropping, how did things reverse in just a few months ?
It’s a long #Thread.
14 Feb, the worst terror attack on security forces happened killing 44 soldiers. Congress supported govt on any impending action, media looked for opportunities to blame Congress. Key question left unanswered.
Amidst mounting pressure govt promised action, says No to dossier diplomacy. In the following days India lost 7 more soldiers in anti terror operations. Media shielded govt & attacked all & sundry. No accountability for Pulwama sought.
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Aijay
@Hejeoma
#Thread 1. My people make una no vex about the gist I promised to drop, the damn thing is too long & too explicit. I have been working with my team of directors at 'HBO' to edit & re-shoot. lol I go do am like 'Game of thrones' & drop it in episodes cos all cant fit in 25 extra
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Avon Healthcare
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So you’ve found that bae of life & you're ready to take the next step. There’s nothing we love more than love but there are health questions you both have to answer before making a lifelong commitment.

Here's a #thread of 5 important steps you must have before marriage.
Since you’re getting married, your future decisions will now be taken for two and you have to take both you and your partner’s health seriously.

Unfortunately, many people let love blind them to serious sexual and reproductive health issues that can become problematic later.
So before going on to start a family, the following are tests you need to take before getting hitched.
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Wale Micaiah
@WaleMicaiah
HAVE YOU LOST YOUR PHONE OR HAS YOUR PHONE BEEN MISSING?

May you not be a victim but these are the steps you can take to prevent collateral damage if you lose your phone.

A #Thread

Cc @yinkanubi

#Beware #BeAware
When people lose their phones, usually they are loss of things like:

The lost phone
The Contacts
The Messages
The Apps
The Images & Videos
...and may be ease of use of their day to day applications/utilities as they have been well accustomed to the workings.
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You can:
Insure your phone on theft.

Install some security solutions that can remotely wipe your data.

Get apps that can track the phone wherever it is & with who.
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Antony Fastier #nofakenews
@fastier_antony
Préliminaire 1 : mes
#tweets n’engagent que mon opinion personnelle.

Préliminaire
2 : je ne suis pas anti- #bio, j’en achète même pour mes élevages
d’insectes (elle sont belle mes fourmis hein !)
Ceci étant dit et comme promis, je vais vous parler des #pesticides #bio. La majorité d’entre vous le sait, 4% vont l’apprendre.
Pour certains je ne vais que répéter des banalités mais c’est toujours bien de répéter ça ancre les choses…
Alors en Europe, nous avons un règlement #bio eur-lex.europa.eu/legal-content/… que vous pouvez lire dans toutes les langues EU . Allez y c’est instructif, un peu chiant aussi comme tous les textes règlementaires. Bon ce qu’on note quand même, c’est que le #bio c’est compliqué.
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