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New GC limits and defaults to allow control over how much memory is used
AssemblyLoadContext replaces AppDomains. Supports unloading assemblies! Also supports loading both managed and native assemblies
Startup hooks allow code to be run *before* the entry point to your application.
New diagnostic tools and APIs 
Performance traces can be collected from running processes for analysis
ReadyToRun publishes partially ahead-of-time compiled native images. This means fast startup. Tiered compilation means that code gets re-JIT compiled to optimize for the target machine at runtime
Publish single (large!) .exe file with all dependencies embedded
Tree shaking to remove unused code paths, assemblies and types from the published application.
Native interop improvements - managed C++/CLI, COM, WinRT.
NativeLibrary replaces DllImport and provides a better cross-platform experience
Hardware intrinsics support, e.g. vector instructions
IAsyncDisposable avoids synchronous flushing of streams
Distributed tracing gives correlated logs across processes, including client / server request lifecycle
Zipkin, Application Insights, etc can be used to view traces
Runtime feature detection - detect whether it is possible to emit generated code, and whether it will be jitted or interpreted
Kestrel no longer requires libuv on *nix. Lower overhead in certain scenarios
Static web content can be distributed in class libraries or packages
Pipeline API provides direct access to buffers etc without using Stream. Avoids allocations
Bedrock allows implementing your own client / server code on top of the Kestrel network stack
Support for trailing HTTP headers
Non-HTML exception pages! Also pluggable support for custom exception responses (e.g. JSON)
Compression improvements over HTTPS
