Thread by @pmyhre

After a lot of work, so proud to finally share this work on #troponin, LV function (#echofirst) and inc HF in the general pop (#ARIC)

1. ⬆️trop is assoc with LV hypertrophy and diastolic (but not systolic!) dysfx

@JAMA_current @JAMACardio @scottdsolomon
ja.ma/2MVFXns

👉🏻Subjects with ⬆️trop AND diast dysfx are at particularly high risk of HF

👉🏻 LV diastolic dysfunction accounts most of the association between troponin and #HFpEF
👉🏻LV Mass accounts for most of the association between troponin and #HFrEF

👉🏻Changes in troponin over 20 years are associated with alternations in LV structure (and not with systolic or diastolic function)

@troponinpapers @johnwmcevoy @J_Boeddinghaus @thomas_nest @baccstudy @HighSTEACS @JJheart_doc @mvaduganathan @yadersandoval @chapdoc1