Thread by @_oatc_

@donnagreen4 @AirisDamon @LisaTMullin @Bernard_Lane @MailOnline 1/ If you are serious, & not the usual sh**poster, just consider a solid trial protocol for agonists. We have an internationally validated psychological instrument for diagnosing the need, that is about 99% accurate, by excluding some who might benefit. So you'd use that to…

@donnagreen4 @AirisDamon @LisaTMullin @Bernard_Lane @MailOnline 2/…select potential subjects but first you need their & parents' fully informed consent, without any coercion, & referring those who instead wish to be treated elsewhere to a suitable centre. So any child who has been told they will offend god, or hurt their parents, or be…

@donnagreen4 @AirisDamon @LisaTMullin @Bernard_Lane @MailOnline 3/…terribly bullied, or will be a freak, if they transition can be included. You have to explain they will get painful monthly injections which may or may not be effective at stopping the the pubertal development that is giving them nightmares and causing suicide attempts. And…

@donnagreen4 @AirisDamon @LisaTMullin @Bernard_Lane @MailOnline 4/…if they aren't effective they must still stick with it, for years, never seeking treatment elsewhere. To ensure survival of your cohort you'd probably need to deeply medicate or ECT some or keep them on hourly suicide watch in an asylum, so they'd need to be warned of that…

@donnagreen4 @AirisDamon @LisaTMullin @Bernard_Lane @MailOnline 5/…possibility, and they'd have to agree. Now, if you got any subjects (and likely any who agreed to no treatment would be people who aren't going to pass the first screening, which includes insistently, persistently & consistently asking for the wrong puberty to be…

@donnagreen4 @AirisDamon @LisaTMullin @Bernard_Lane @MailOnline 6/…prevented & the right one provided), & gave them the first (painful) placebo injection, they'll know within days if it was real or placebo because agonists cause a massive increase in the "wrong" hormones at the start of treatment. So that's the placebo element gone, in days.

@donnagreen4 @AirisDamon @LisaTMullin @Bernard_Lane @MailOnline 7/…From then you've got the task of forcing them to continue on your "trial", regularly complying honestly with its requirements, turning up for appointments, not seeking relief elsewhere (whether agonists, borrowing someone's Pill, or suicide), honestly answering your…

@donnagreen4 @AirisDamon @LisaTMullin @Bernard_Lane @MailOnline 8/…continued psychological assessments, until every bit of the irreversible, lifelong harm of the wrong puberty has been inflicted, & you can write up your results, & try to get it published in reputable journal - because otherwise it is of no consequence. Oh, & before you…

@donnagreen4 @AirisDamon @LisaTMullin @Bernard_Lane @MailOnline 9/…can do any of that, any at all, you have to get full authorisation, in detail, from an accountable research ethics committee, and funding, including covering any in-patient asylum care needed.

Now, do you think any of that is either ethical, or practically possible?

@donnagreen4 @AirisDamon @LisaTMullin @Bernard_Lane @MailOnline cc @threadreaderapp unroll please

@donnagreen4 @AirisDamon @LisaTMullin @Bernard_Lane @MailOnline @threadreaderapp Errata: In 1/ for trial of agonists read trial either of agonists or denial of agonists. In 3/ for "can be included" read "cannot be included because they are under coercion".

One also needs to point out such a trial would require subjects be followed up for decades.