Thread by @CRISPRjournal

ONLINE Now: "The Ethics of Human Genome Editing"
Very pleased to share our first special issue.
Guest editors: @sarahwchan @shsternberg; cover art by @monooyee
liebertpub.com/toc/crispr/2/5

@sarahwchan @shsternberg @monooyee The first of nine Perspectives is from @HankGreelyLSJU, who argues that germline editing is not inherently bad or unethical, but the technology is unlikely to be particularly useful in the near future.
liebertpub.com/doi/full/10.10…

@sarahwchan @shsternberg @monooyee @HankGreelyLSJU In "Democratic Governance of Human GGE", @sahakris, Ben Hurlbut and @SJasanoff argue that new commissions to study GGE are "premature and problematic" and offer six recommendations.
liebertpub.com/doi/10.1089/cr…

@sarahwchan @shsternberg @monooyee @HankGreelyLSJU @sahakris @SJasanoff Kerry Lynn Macintosh (@santaclaralaw): 3 reasons against a moratorium: 1) danger of a temporary ban becoming permanent; 2) disincentive to make technology safer; 3) the potential stigmatization of children born with edited genomes.
liebertpub.com/doi/10.1089/cr…

@sarahwchan @shsternberg @monooyee @HankGreelyLSJU @sahakris @SJasanoff @santaclaralaw Ross Wilson & Dana Carroll discuss the "Daunting Economics of Therapeutic Genome Editing", which "must avoid several pitfalls that could substantially limit access to its transformative potential, especially in the developing world.”
liebertpub.com/doi/10.1089/cr…

@sarahwchan @shsternberg @monooyee @HankGreelyLSJU @sahakris @SJasanoff @santaclaralaw Manuel Viotti et al. @ZouvesFertility provide an IVF perspective on GGE, and calculate numbers of potential cases that might benefit from GGE where PGT would not work. The numbers are very small...
liebertpub.com/doi/10.1089/cr…

@sarahwchan @shsternberg @monooyee @HankGreelyLSJU @sahakris @SJasanoff @santaclaralaw @ZouvesFertility .@jsherkow writes on "Controlling CRISPR through Law" -- the role that the law can and does play in policing the introduction of ethically problematic uses of the technology.
liebertpub.com/doi/10.1089/cr…

@sarahwchan @shsternberg @monooyee @HankGreelyLSJU @sahakris @SJasanoff @santaclaralaw @ZouvesFertility @jsherkow Jodi Halpern and colleagues @igisci ask: "How can we secure human rights?" and propose a Human Rights Impact Assessment "to evaluate the potential burdens that such biomedical interventions may place on human rights." liebertpub.com/doi/10.1089/cr…

@sarahwchan @shsternberg @monooyee @HankGreelyLSJU @sahakris @SJasanoff @santaclaralaw @ZouvesFertility @jsherkow @igisci Bartha Knoppers & @ErikaKleiderman ask "Who speaks for 'Future' Children?" Children have "distinct rights and interests." A moratorium "neither fosters their best interests or health nor respects their right to benefit from the advancements of science."
liebertpub.com/doi/10.1089/cr…

Also in this issue: an interview with Bartha Knoppers, who is a member of the @theNASEM commission on germline editing.
liebertpub.com/doi/10.1089/cr…

@theNASEM This issue includes two research studies from Kelly Ormond and coworkers:
"Attitudes Toward Hypothetical Uses of Gene-Editing Technologies in Parents of People with Autosomal Aneuploidies"
liebertpub.com/doi/10.1089/cr…

@theNASEM "Attitudes of Members of Genetics Professional Societies Toward Human Gene Editing" -- an international survey of 500 professionals shows little support for enhancement (conducted before #CRISPRbabies)
liebertpub.com/doi/10.1089/cr…

@theNASEM "How beauteous mankind is! O brave new world /That has such people in't!”
A wonderful essay by @derek___so on "The Use and Misuse of Brave New World in the CRISPR Debate" liebertpub.com/doi/10.1089/cr…