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Linking a bacterium genotoxin and colon #cancer for the 1st time in organoids, and the mutational signature in validated in affected patients @nature @HansClevers @Cayetanopm @_Hubrecht nature.com/articles/s4158…
@nature @HansClevers @Cayetanopm @_Hubrecht Such an important smoking gun for the gut #microbiome's potential contribution to cancer, just as we've recently seen it's ability to protect from cancer
nature.com/articles/s4156… @NatureMicrobiol
@nature @HansClevers @Cayetanopm @_Hubrecht @NatureMicrobiol Watch this gut #microbiome and #cancer space.
It looks like we're just scratching the surface
nature.com/articles/s4156…
nature.com/articles/s4156…
@NatureRevCancer
@EranElinav
@nature @HansClevers @Cayetanopm @_Hubrecht @NatureMicrobiol @NatureRevCancer @EranElinav I also wonder whether the mysterious, big spike in young people with colon #cancer has something to do with genotoxic bacteria like the E Coli published this week (top of thread, @nature)
washingtonpost.com/national/healt… @PostHealthSci
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Eric Topol
@EricTopol
We have the wrong "flattening of the curve" in the U.S.
The pathetically slow, sluggish response to #COVID19 testing, social distancing, key decisions, aggressive action. As the virus impact quickly grows.
@CDCgov @WhiteHouse @US_FDA
As @genomedan points out "It's even worse that that"
so I added the real US #COVID case graph
With adjusted case graph via @genomedan
Read 3 tweets
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Eric Topol
@EricTopol
"Dangerously and absurdly, political leaders have been using the low number of confirmed cases as the evidence of success when it is actually a measure of our blindness."—@MJGerson
washingtonpost.com/opinions/coron… #COVID19 @PostOpinions
"how long it took to cut through red tape to try to save lives in an outbreak" --@HelenChuMD @UWMedicine
“What they [@CDCgov and @US_FDA] said on that phone call very clearly was cease and desist to Helen Chu. Stop testing.” nytimes.com/2020/03/10/us/…
@sherifink @bymikebaker
Disappointing that @nytimes didn't credit @amymaxmen @nature @naturenews who was all over the #CDCgov and @US_FDA obstruction of #COVID19 testing by @HelenChuMD @UWMedicine @UWVirology @seattleflustudy 1 week earlier
nature.com/articles/d4158…
Read 3 tweets
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Eric Topol
@EricTopol
From pandemic to pandemonium:
If anyone thinks flu has any resemblance to #COVID19, all you have to do is look at the massive necrosis of the lung on a CT scan in an affected patient. That doesn't happen w/ flu. Image
We don't yet know the case fatality rate (CFR), infected fatality rate (IFR) the denominators, the % asymptomatic carriers. We still don't know a lot about #CODIV19. But we do know it's a very potent virus, & unlike those we know. We ought to get serious about social distancing.
The image I posted above was not intended to represent massive necrosis; it was from a prior #COVID19 report. The point I am making is that a distinctive (likely pathognomonic) CT scan appearance for this virus is accumulating and is markedly differentiated from flu.
#COVID≠flu
Read 5 tweets

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Chris Tape
@christophertape
Extremely proud to share my lab’s first paper: ‘Cell-Type Specific Signaling Networks in Heterocellular Organoids’ out today in @naturemethods (1/14) nature.com/articles/s4159…
#Organoids are amazing biomimetic tissue models that contain multiple cell-types (e.g. stem, differentiated), each in their own cell-state (e.g. proliferating, quiescent, apoptotic). (2/14)
While this complexity is what makes organoids so useful, it also makes them tricky to study. My lab wanted to use organoids to study cell-signalling in cancer – but bulk methods (e.g. LC-MS/MS) couldn’t easily provide cell-type and cell-state specific signalling data. (3/14)
Read 14 tweets
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Dr. Cecilia Tomori
@DrTomori
@sophiejrigney @elizabethmoya @makesmilk @babyfriendly Anthropologist here - I have written about changing ideas about #time and about the regulation of infants quite a bit. These are #culturalideologies that came about in late 19th-early 20th century in response to social changes 1/n
@sophiejrigney @elizabethmoya @makesmilk @babyfriendly the rise of industrial #capitalism changed labor practices and emphasized efficiency and predictability. The #clock was particularly important in this regard.
@sophiejrigney @elizabethmoya @makesmilk @babyfriendly There was a fundamental reworking of #time from a very different understanding - agricultural labor has a very different rhythm (EP Thompson famously wrote about this) jstor.org/stable/649749?…
Read 9 tweets
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Victoria Brownworth
@VABVOX
This day has been so hard.
It's been a year since my last surgery.
I lost correct count of how many surgeries I have had, but it's close to two dozen over my life time.
So many scars on my body and psyche.
I am legit terrified of this next surgery.
I'm so shaky tonight, folks. 😷
People with #cancer are supposed to be brave and model courage for others, but the fact is, it's just the loneliest and scariest of journeys.
I have watched people I admired chart their slow deaths on here.
Quite simply, I don't want to be one of them.
Brave, yes.
Dying, no.😷
Watching #TonyBennett (yes, I am so freaked out I am watching a country #Christmas special, although it's had a lot of jazz for a country special & not much country) belt out tunes with Diana Krall at 92, I want that--decades more time. I want years more of my voice out there.
Read 6 tweets

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#PtExp #clinicaltrial #biomedicalization #PJI #PuvisdeChavannes #neckties #Organoids #Fragonard #Resistance #AbigailWexner #Time #surrealist #disability #secte #BoycottWexner #UnblockHealth #CNRSLeJournal #PabloServigne #Raphael #medtwitter #Euratom #patients #ThérapiesAlternatives #Ties #TF1

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