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ACE inhibitors, 1 of the most commonly used class of drugs for hypertension, have been a subject of #COVID19 confusion d/t the virus hijacking cells via ACE-2. But @NephJC sets this straight really well nephjc.com/news/covidace2
and @escardio's statement
escardio.org/Councils/Counc…
And we keep seeing hypertension as a risk factor for death. That didn't make much sense and may well just be a proxy for age, aptly pointed out by @NephJC's blog (<-so well done)
graph wsj.com/articles/whos-… @betswrites
Like ACE inhibitors engendering #COVID19 confusion, so are anti-inflammatory, NSAID drugs. And the same message—no evidence to stop or change
My rheumatologist friend @RonanTKavanagh elaborates why ronankavanagh.ie/blog/anti-infl…
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More from @EricTopol see all

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Eric Topol
@EricTopol
It's time to clear up the issues about testing. So I've put together a #COVID19 thread on spread.
Addressing the Super-spreaders, Spreaders, and the essentiality of testing
Let's start in China where the 1st cases were manifest.
A @ScienceMagazine yesterday provided elegant modeling from real data to show that 79% of the spread was from people without #COVID19 detection.
Now Singapore, which dealt with 3 clusters by having tight surveillance of pneumonia, testing immediately and tracing all the contacts
thelancet.com/journals/lance… @TheLancet
Read 9 tweets
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Eric Topol
@EricTopol
What will go down as the biggest breakdown in the US response to #COVID19 is the lack of test kits. South Korea and the US had their 1st patients on Jan 20 and Jan 21, respectively. Look at the difference in daily testing. By March 4th, SK was ~18,000 per day.
On March 14, Dr. Barbara Birx did, "When you are tested, and our results look very similar to South Korea now, with South Korea with 96% plus of people with symptoms are negative." That's 4% positive by CDC tests.
Fully transparent: @COVID19Tracking w/ a 9.7% positive rate today
Similar plot of South Korea vs US #COVID19 test data today @nytimes; it includes more recent CDC data, the cumulative N of tests 55 days after each country's 1st patient was diagnosed, confirmed cases, and has a different Y-axis display from mine
nytimes.com/interactive/20…
Read 6 tweets
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Eric Topol
@EricTopol
A new @ScienceMagazine paper is the best evidence yet for the people without symptoms ("undocumented," i.e. with no or mild Sx, not tested) driving the spread #COVID19
science.sciencemag.org/content/early/… brilliant modeling of synthetic outbreak
via @hholdenthorp
If anyone questioned the value of social and physical distancing, this ought to help squelch it.
#StayHomeSaveLives stayhomesavelives.us
I'm taking the liberty of changing the headline of this very good @CNN piece
by @elizcohencnn cnn.com/2020/03/14/hea…
Read 5 tweets

Related threads

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Harlan Krumholz
@hmkyale
Participating in an intern'l webinar with the Chinese Cardiology Association to discuss lessons learned with #COVID-19. Learning from our colleagues. Helping us to prepare. Teamwork. @ACCinTouch #ACCIntl All welcome. From 8-10 EDT. Today March 18.heartm.docbook.com.cn/#/meeting_noti… #COVID19
@ACCinTouch Chinese colleagues making strong point about the asymptomatic transmission. Bin Cao emphasizing the importance of using the N95 masks. For healthcare workers. [Implication: importance for us to solve the shortage problem - he is giving a warning; talking about risk to HCWs.]
@ACCinTouch Chinese colleagues sharing clinical features of #COVID19; one distinctive thing is that dry cough common; but little difference in presentation with flu. In Wuhan experience… 12% had acute cardiac injury. 7% acute kidney injury.
Read 21 tweets
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Faheem Younus, MD
@FaheemYounus
So I’m hearing many myths about #COVID-19 and would like to quickly clear the record.

Coronavirus will go away in Sumer months.

Wrong. Previous pandemics didn’t follow weather patterns plus as we enter summer, there will be winter in the Southern Hemisphere. Virus is global.
Myth #2: In summer, the virus will spread more due to mosquito bites.

Wrong. This infection is spread via respiratory droplets, not blood. Mosquitos don’t increase spread.
Myth #3: If you can hold your breath for ten seconds without discomfort, you don’t have COVID.

Wrong: Most young patients with Coronavirus will be able to hold their breaths for much longer than 10 seconds. And many elderly without the virus won’t be able to do it.
Read 11 tweets
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El internista.
@MediCasos
HILO.

Revisión de artículos e información CIENTIFICA que hay hoy en día sobre el manejo, prevención diagnóstico y tratamiento de #COVIDー19

Atentos.
1. Kings Critical Care.

Fisiopatología:, Xu et al 2/17

SIRA: Caracterizado por daño alveolar difiuso (membranas hialinas).
Se observa daño viral citopatico en los neumocitos, lo que implica daño viral directo, mas que "solo" inflamación.
- Tormenta de citoquinas:
Parecido a sepsis bacteriana o linfohistiocitosis hemofagocitica.

Clínicamente esto se ve con aumento de la PCR y ferritina que aparentemente sirve de seguimiento de severidad y mortyalidad.

Kings Critical Care.
Read 72 tweets
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Mona Eltahawy
@monaeltahawy
An estimated 550,000 people to homeless on any given night in the US. As #Coronavirus spreads, homeless people and their advocates are preparing for an outbreak in a population more susceptible to illness and with no way to isolate or recover at home. google.com/amp/s/mobile.r…
“Shelters and healthcare providers from Los Angeles to Boston are attempting to erect quarantine zones and purchase protective gear to stop the virus from spreading to the roughly 1% of Americans who are homeless at some point in a given year.” #COVIDー19
"In a shelter system that is already bursting at the seams, the ability to isolate and quarantine people and families is going to be very difficult and very expensive," said Aine Duggan, president of homeless advocacy group Partnership for the Homeless in New York. #Coronavirus
Read 8 tweets
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Disaster Artists: The Movie Survival Podcast
@DisasterArtists
So, the Stallone sci-fi classic Demolition Man was almost definitely written by a time traveler from 2032, a world that survived #COVIDー19

#cornoravirus
For one, the film shows how the survivors made sure there would never be a toilet roll shortage again.

#toiletrollcrisis #toiletpaper
Even expressive high-fives between colleagues involve no hand touching
Read 7 tweets
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NotTheMacAnon
@NotTheMacAnon1
@Tara59618340 @angerose56 Thank you, God bless you and you’re more than welcome. 🙏🏻🕯😘
@Tara59618340 @angerose56 Ps
@Tara59618340 @angerose56 A gyroscope (from Ancient Greek γῦρος gûros, "circle" and σκοπέω skopéō, "to look") is a device used for measuring or maintaining orientation and angular velocity.
Read 89 tweets

Trending hashtags

#irancorona #influenza #openscience #COVIDー19 #China #Coronavirus #Coronvirus #EMPAREG #COVID #Covid #FightFlu #Covid_19 #NephJC #CoronaVirus #COVID19 #COVID2019 #toiletrollcrisis #wewillneverforget #coronavirusitalla #irancoronavirus #Coronavirusmexico #coronavirus #YemenCantWait #toiletpaper #SaturdayMorning

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