1/ Rant coming
I hate journalism that wants to tell a sexy story, and in doing so, selectively ignores facts.
It is the case here with @jetjocko's reporting of chloroquine.
The chloroquine/hydroxychloroquine hypothesis did not start with the French study!
I hate journalism that wants to tell a sexy story, and in doing so, selectively ignores facts.
It is the case here with @jetjocko's reporting of chloroquine.
The chloroquine/hydroxychloroquine hypothesis did not start with the French study!
2/ The idea of it came from off-label use by frontline doctors in China and Korea.
The scientific rationale came from post-SARS research in 2004 by Belgian researchers
ncbi.nlm.nih.gov/pubmed/15351731
The scientific rationale came from post-SARS research in 2004 by Belgian researchers
ncbi.nlm.nih.gov/pubmed/15351731
3/ For the COVID19 outbreak, Chinese doctors trialed chloroquine seems to have curative effect.
This was reported Feb 17:
xinhuanet.com/english/2020-0…
It was then unanimously suggested to be included in the Chinese COVID19 treatment protocol (6th edition)
This was reported Feb 17:
xinhuanet.com/english/2020-0…
It was then unanimously suggested to be included in the Chinese COVID19 treatment protocol (6th edition)
4/ Chinese scientists then quickly confirmed in vitro antiviral activity of hydroxychloroquine for COVID19
academic.oup.com/cid/advance-ar…
academic.oup.com/cid/advance-ar…
5/ Feb 13, South Korean COVID-19 Central Clinical Task Force also started recommending hydroxychloroquine for COVID19. Presumably from clinical experience.
koreabiomed.com/news/articleVi…
koreabiomed.com/news/articleVi…
6/
March 1: Italian society for infectious and tropical diseases in the Lombardy region added chloroquine/hydroxychloroquine to its treatment guidelines
March 1: Italian society for infectious and tropical diseases in the Lombardy region added chloroquine/hydroxychloroquine to its treatment guidelines
7/
There are now 13 trials planned to test chloroquine or hydroxychloroquine in one of the treatment arms. Total target pt enrollment is >1600. I am excluding the Papua New Guinea trial here.
There are now 13 trials planned to test chloroquine or hydroxychloroquine in one of the treatment arms. Total target pt enrollment is >1600. I am excluding the Papua New Guinea trial here.
8/
Seriously, inferring to readers that chloroquine/ hydroxychloroquine has no more scientific evidence than camostat mesylate???
Is this a joke? The evidence is based on a SINGLE in vitro study and NO clinical experience.
There are NO trials planned for camostat!
Seriously, inferring to readers that chloroquine/ hydroxychloroquine has no more scientific evidence than camostat mesylate???
Is this a joke? The evidence is based on a SINGLE in vitro study and NO clinical experience.
There are NO trials planned for camostat!
9/ Journalists, get your shit together! Don't try to be the next Malcolm Gladwell. Reporting facts is more important than telling a edgy story of some cryptocurrency dudes making up a clinical trial result.
end of rant/
end of rant/
10/
Addendum. Had the author spent the same amount of time researching COVID19 treatment protocols and trials rather than tracking down the biographies of 2 twitter guys, he would have quickly learned the same info I outlined
Addendum. Had the author spent the same amount of time researching COVID19 treatment protocols and trials rather than tracking down the biographies of 2 twitter guys, he would have quickly learned the same info I outlined
11/
Another addendum. Chloroquine chatter did just start with the French study. I tweeted Chinese report of efficacy March 12
https://t.co/0R3TAQfyjb
Another addendum. Chloroquine chatter did just start with the French study. I tweeted Chinese report of efficacy March 12
https://t.co/0R3TAQfyjb
12/ hydroxychloroquine is being recommended as a frontline treatment in US hospitals RIGHT NOW.
Here is the UCSF guideline:
Here is the UCSF guideline:
