Dr. Manigreeva Krishnatreya Profile picture
Sep 21, 2020 11 tweets 3 min read Read on X
Let’s talk about #Immunity and #COVID19! In the narrative of an army and enemy.
Our immune system is like an army. Its mission? To protect us from enemies both foreign (viruses and bacteria) and domestic (diseases like cancer).
When the enemy (#SARSCoV2 for COVID19).. 1/n
..enters our body, our army’s first line of defence with army’s surveillance officer (helper T-Cells) are pressed into action. The enemy (viruses) can enter cells by infecting cells directly, leading to replication of virus inside the cells. During this process, 2/n
some of the viral proteins (enemy’s target body parts, usually the brain or heart is better for one-go kill) will be degraded into peptide fragments, which will be recognized by the army’s surveillance officer (presented on these helper T-Cells). 3/n
Through a series of events from priming to eventually getting readied, now our army’s men and women with the artillery guns (Killer T-Cells) will fire bullets (cytotoxic granules) and kill the enemy. This process is short and can clear the enemy army (virus) effectively ..4/n
.. without much noise (symptoms). Now, in case, the enemy survives this artillery gunners (T-Cell), then it has overwhelmed our primary resources (now minor symptoms will appear), but it has not yet reached the parliament. At this point, the second command .. 5/n
.. with tanks and bombers (B-Cells) are sent to the rescue mission. Once activated, initially these tanks (B-Cells) will fire heavy ammunitions (short lasting IgM) and once, this short lasting ammunitions are exhausted, it will fire the bigger missiles and ..6/n
.ammunitions (long lasting IgG) to clear the enemy from our body. At this stage, our artillery gunners (T-Cells) are also providing cover firing support (releasing cytokine) to tanks and bombers (B-Cells). At this stage, the war is full blown!! Now, ..7/n
.. due to lack of proper coordination between artillery gunners and tanks (T-Cells and B-Cells) due to higher number of enemy's army (*high viral load), there is leak of false information (bad cytokines) and at this point, our army fails to recognize the enemy and ..8/n
.. starts shooting our own body’ cells (cytokine storm). This type of poor coordination between various wings of the army (T-Cell and B-Cell) is seen in elderly population and people deficient of #vitaminD , and other essential vitamins/minerals. 9/n
No wonder, people of all ages are succumbing to this common enemy, more often the elderly. In children though, as recently their army were trained (by multiple dosage of vaccines), they don’t misfire and their army is well regulated, thanks to the training !! 10/n
*Masks help in reducing the number of enemies (high viral load). END 🙏🙏

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More from @manigreeva

Oct 30, 2021
Coincidence of a series of coincidences ! This thread is for those who love 💘 #coincidences. A 🧵 ... 1/n
It is just a coincidence that the World Economic Forum (#WEF) and Bill Gates et al reviewed a meeting in 2019 and predicted about a possible future viral pandemic, just before the #COVID #pandemic. It must be another plain coincidence that a viral pandemic began exactly 2/n
.. in the place where there is a level-4 #virology laboratory (#Wuhan). It was a coincidence that, whole world followed China's #lockdown policy with ZERO #scientific and #economic basis. 3/n
Read 8 tweets
Apr 15, 2021
Given the full community spread of #SARS_CoV_2, it is time to stop incessant #RTPCR testing in asymptomatic people, so called "healthy sick" , and save resources. Start early Rx with ivermectin+budesonide+Zn+ chicken soup+kadha or whatever in mild to moderate #Covid_19 cases. 1/n
And, reserve #ICUs for serious #Covid patients only. Start triage and stop the use of #Remdesivir and #convalescentplasma therapy ASAP, as it doesn't help save lives. Don't hospitalize maniacs hyperventilating due to fear in the Covid ward and shift them to counseling ... 2/n
.. for managing hyper active state of mind & deactivate their social media accounts + WhatsApp. Public health intervention with #VitaminD 60k once week for 4 weeks starting now and not while patient is sick with #Covid By then it will not help to build adequate VitD reserve..3/n
Read 6 tweets
May 19, 2020
. @CovidIndiaSeva I beg your kind attention here ! If we look at proportion of #Covid_19india patients on #ventilator support, it is 0.4% to 0.5%, which reflects ARDS due to Pneumonia due to #COVID19 as cause of death (COD) ( @WHO code: U07.1/2)... 1/n
So, around 150 deaths in 3000 projected deaths are actually due to #Covid_19india Epiphenomenon: People with diabetic complications, advanced cancer etc where the main COD is underlying health conditions, but #COVID19 can only be a contributing cause .. 2/n
Vast majority of #COVID19 deaths in India could be an epiphenomenal death only, considering #BCG vaccine induced trained #Immunity (Nature paper link at the end of this thread) that offers protection from severity of #Covid_19india . Why I am saying this is more important.. 3/n
Read 5 tweets
Apr 15, 2020
The real figure in Covid-19 is the infection mortality rate (IMR), as I mentioned earlier. Case fatality rate would be higher, as testing in symptomatic cases only will reduce the denominator. Large population testing in Germany showed IMR to be 0.3%.. 1/n Image
Even at 1.3% mortality in Germany where testing included mild cases and 8.7% in UK where testings were done in severe cases, >80% of deaths occurred in persons above 65 years. Add to this, their population >65 years which is between 18% to 20%, ...2/n
..and compare this to India's geriatric population of just over 6%. Taken all these factors, in India, IMR will be 0.09% or even less, which is good for allowing herd immunity with reverse quarantine with least possible population deaths.. 4/n
Read 8 tweets

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