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Dena Grayson, MD, PhD Profile picture
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7 Oct, 4 tweets, 3 min read
šŸšØBREAKING: Eli @LillyPad has reĀ­quested emergency-use auĀ­thoĀ­rizaĀ­tion from FDA of its anĀ­tiĀ­body-based treatĀ­ment LY-CoVĀ­555ā€”a drug similar to the Regeneron antibody drug given to Trumpā€”for peoĀ­ple with reĀ­cently diĀ­agĀ­nosed, mild-to-modĀ­erĀ­ate #COVID19.
wsj.com/articles/eli-lā€¦
LilĀ­lyā€™s anĀ­tiĀ­body therapy mimics human anĀ­tiĀ­bodĀ­ies that can neuĀ­tralĀ­ize the new #coronavirus, simĀ­iĀ­lar to the exĀ­perĀ­iĀ­menĀ­tal anĀ­tiĀ­body-based treatĀ­ment from ReĀ­genĀ­eron (mixture of 2 antibodies) that was given to @realDonaldTrump. šŸ§¬šŸ¦ 

#COVID19
LY-CoVĀ­555, a manufactured antibody based on an antibody found in one of the earĀ­liĀ­est US surĀ­vivors of #COVID19, reportedly reĀ­duced viral loads and the rate of hosĀ­piĀ­talĀ­ization/ER visits of #COVID19 patients to 1.7%, comĀ­pared to 6% for placebo.
investor.lilly.com/news-releases/ā€¦
Lilly says a new study showed that comĀ­binĀ­ing LY-CoVĀ­555 + anĀ­other anĀ­tiĀ­body (similar to Regeneronā€™s Ab cocktail) reĀ­duced viĀ­ral load, sympĀ­toms and hosĀ­piĀ­talĀ­izaĀ­tions in #COVID19 paĀ­tients. Lilly exĀ­pects to seek emerĀ­gency use auĀ­thoĀ­rizaĀ­tion for the comĀ­bo in NoĀ­vember.

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More from @DrDenaGrayson

Dena Grayson, MD, PhD Profile picture
8 Oct
šŸ”„WHOA. In an unprecedented move, the editors of the prestigious New England Journal of Medicine condemn the Trump administration for its FAILED response to the #coronavirus pandemic.

And they call for @realDonaldTrump to be VOTED OUT.šŸ’„

@NEJM #COVID19
nejm.org/doi/full/10.10ā€¦
ā€œThe magnitude of this failure is astonishing. The US leads the world in #COVID19 cases and in deaths. The death rate in this country is more than double that of #Canada, exceeds that of #Japan, a country with a vulnerable and elderly population, by a factor of almost 50.ā€šŸ’„
We have FAILED at almost every step. We had ample warning, but when the disease 1st arrived, we were incapable of testing effectively & couldnā€™t provide even the most basic #PPE to health care workers and the general public. And we continue to be way behind the curve in testing.
Read 10 tweets
Dena Grayson, MD, PhD Profile picture
4 Oct
šŸšØBREAKING: Trump didnā€™t disclose a POSITIVE rapid #COVID19 test result he received *on Thursday* before appearing on Fox News when he didnā€™t reveal it either, instead claiming he was awaiting results.

Trump tried to #coverup having tested positive.šŸ¤¬

wsj.com/articles/trumpā€¦
Trump's 1st positive was a "rapid antigen" #coronavirus test (quick, not as sensitive as PCR). His 2nd, confirmatory test used PCRā€“amplifies genetic material from the virus (more sensitive, not as quick).

Trump KNEW of his 1st positive, but said NOTHING.
šŸ˜±As the #coronavirus spread among the people closest to him, Trump asked an adviser NOT to disclose results of their own positive test. ā€œDonā€™t tell anyone,ā€ he said.

This is RECKLESS and DANGEROUS. Contact tracing #COVID19 cases is crucial to containing a #CoronavirusOutbreak.
Read 5 tweets
Dena Grayson, MD, PhD Profile picture
4 Oct
As I warned, Trumpā€™s condition was much more serious than revealed. His condition was deteriorating faster and earlier in the course of illness than is typical in #COVID19. Thus, the unproven antibody cocktail, #remdesivir (used for seriously ill patients), and now dexamethasone.
Patients with @COVID19 are hospitalized a median of 9days after onset of symptoms. Trumpā€™s became symptomatic on Wednesday at the earliest, so today is Day 5. Yet Trump needed oxygen and hospitalization by Day 2.

Itā€™s VERY CONCERNING that Trump was treated with dexamethasone. As @DrEricDing points out, dex is NOT effective in patients NOT on O2. Biggest benefit is for patients on O2/ventilator, less so for O2 only.

#TrumpCovid #coronavirus
Read 11 tweets
Dena Grayson, MD, PhD Profile picture
2 Oct
ā€¼ļøGuilfoyleā€™s assistant alleges Guilfoyle ā€œsubjected her frequently to degrading, abusive & sexually inappropriate behavior...(Guilfoyle) displayed herself naked & (shows) photographs of the genitalia of men with whom Guilfoyle had had sexual relations.šŸ¤®
newyorker.com/news/news-deskā€¦
The complaint alleges that Guilfoyle ā€œspoke incessantly & luridly about her sex life and...demanded a massage of her bare thighs; Guilfoyle told her to submit to a Fox employeeā€™s demands for sexual favors, encouraged her to sleep with wealthy and powerful men...šŸ¤¬šŸ¤®
...(Guilfoyle) ā€œasked her to critique her naked body, demanded that she share a room with her on business trips, required her to sleep over at her apartment, and exposed herself to her.ā€šŸ¤¬šŸ¤®
Read 7 tweets
Dena Grayson, MD, PhD Profile picture
2 Oct
āš ļøIf Hope Hicks traveled within close proximity to Trump aboard Air Force Oneā€”presumably while NOT wearing a maskā€”then Trump likely was exposed to the #coronavirus.

However, that does not necessarily mean itā€™s likely that Trump will be infected and/or get sick. 1/

#COVID19
A large study in #India of over 500,000 people showed that **only 8%** of #coronavirus-infected people accounted for 60% of all new infections.

These are ā€œsuperspreaders.ā€ šŸ¦ 
In this same study, the chances that a #coronavirus-infected person spread the virus to a household contact (CLOSE contact) was only 9%.

#COVID19 #TrumpVirus
Read 4 tweets
Dena Grayson, MD, PhD Profile picture
1 Oct
ā€¼ļøStudy of 38 million English-language articles about the #CoronavirusPandemic finds that mentions of Trump made up nearly 38% of the overall ā€œmisinformation conversation,ā€ making the Trump the largest driver of the ā€œinfodemic ā€”LIES about the #pandemic.šŸ¤¬
nytimes.com/2020/09/30/us/ā€¦
Lead @Cornell researcher Sarah Evanega says that Trump "was the single largest driver of misinformation around #Covid. Thatā€™s concerning in that there are real-world dire health implications.ā€

Trump's LIES cost LIVES.šŸ¤¬

#coronavirus #TrumpLiesPeopleDie
The study identified 11 topics of misinformation. By far the most prevalent one was ā€œmiracle cures,ā€ including Trumpā€™s hawking of #hydroxychloroquine and disinfectants as potential #COVID19 treatments, accounting for more misinformation than the other 10 topics *combined*.šŸ¤¬
Read 4 tweets

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