In the #US & #Mexico trial of #Novavax vaccine (where 50% were #Alfa variant), it shows an overall efficacy of 90.4% & 100% efficacy against moderate or severe disease, on par with the vaccines made by Pfizer-BioNTech and Moderna…
“Novavax may be used as a booster in the U.S., but it’s certainly will be the first vaccine a lot of people are going to see around the world”
#Novavax new booster vax against #Beta variant is also found highly immunogenic in #baboon studies. A strong anamnestic response was demonstrated in baboons boosted with rS-B.1.351 approximately one year after immunization with #NVXCoV2373 (rS-WU1)…
@Novavax This high efficacy across all categories is incredibly impressive (even when comparing to Pfizer & Moderna) because this trial was done with circulating variants of concern (#VOC).
And above all, #Novavax is as safe as a placebo!
➡️ Side effects: much lower than mRNA & viral vector vaccines ➡️ Only a very low number of serious & severe adverse events, but they occurred equally in the vaccine and placebo groups
US disinterest in according EUA to #Novavax may benefit #India. As per Indian government estimates, 200 million Novavax shots (50 million a month) can be available during September-December & number may rise…

• • •

Missing some Tweet in this thread? You can try to force a refresh

Keep Current with Vipin M. Vashishtha

Vipin M. Vashishtha Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!


Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @vipintukur

14 Jun
#DELTA DIARY: It is clear we are now dealing with a virus that spreads far more easily - probably more than twice as easily - as the version that emerged in #Wuhan at the end of 2019 1/…
The #Ro was around 2.5 when the pandemic started in Wuhan and could be as high as 8.0 for the Delta variant 2/
DELTA is evolving: A new, more genetically diverse cluster, lineage AY.1 (which is termed as #Delta+) with a new spike substitution #N417K having immune escape property, has emerged independently in some countries @vinodscaria 3/
Read 9 tweets
13 Jun
After almost 6 months of global rollout of #Covid19 vaccines, we have some data to assess their comparative efficacy/effectiveness. There seems to be a gradient in their performances:
*Best performing: BNT162b2 (Israel, US & UK) & Moderna’s mRNA & Sputnik-V (Bahrain) 1/
*Moderately effective: #AstraZeneca (UK), #JNJ (US, data still evolving)
*Modestly effective: #Sinovac’s CoronaVac (Chile, Brazil, Uruguay, Middle East) #Sinopharm’s inactivated (Seychelles, Mongolia) 2/
But on safety front, the #inactivated vaccines have scored over all others, both on reactogenicity front & as far as rare, serious AEFIs are concerned 3/
Read 5 tweets
5 Jun
What does #HerdImmunity mean in context with #SARSCoV2?
We don’t need the entire population to be vaccinated or the vaccines to be 100% effective (they never are); we just need them to reduce infection rates enough to get us <1. That is herd immunity 1/…
The issue is more complex. Despite achieving high seropositivity in certain regions, resurgences have occurred. And in certain regions/countries, the virus suddenly retracted even in the absence of a significant sero-positivity 2/
It is not a pure mathematics. There is an interplay of infection or vaccine-induced immunity & the evolution in the virus. The 'Ro' is not a fixed number--keep on changing with the virus transmissibility. With this changes the thresholds to achieve 3/
Read 6 tweets
4 Jun
How did #India fare? The graphic tells the whole story:
➡️Brutal onslaught by #B16172: having the highest transmissibility & most immune evader of all VOCs with higher virulence?
➡️No support from Vaccination (negligible coverage & high breakthrough, but reinfections rare) 1/
➡️ Social mitigation measures worked! Or the virus ran out of steam? Or still too early to conclude?
➡️ India struggled (significant mortality/health infrastructure collapsed) but survived!! 2/
New study on immune escape potential of #B16172 in comparison to #B1351 w/ #BNT162b2 vaccine: More immune evader than even B1351 VOC! Significant loss of antibody neutralisation vs live B16172 (-5.8x, akin to B.1.351) @TheLancet 3/…
Read 6 tweets
3 Jun
#CDC has recently reported myocarditis & pericarditis cases following #mRNA #vaccination in adolescents & young adults in the US. Are these the first reported cases of cardiac involvement following mRNA vaccines? 1/…
Fortunately, these incidents are extremely rare events. But, have the agencies overlooked earlier signals? Are these cases indeed related to mRNA vaccines? Are the vaccines responsible? If yes, what could be the probable mechanism? 2/
Few cases of post-vaccination myocarditis, heart failure & heart attacks have been reported in #Israel since December soon after the launch of #Pfizer mRNA vaccine. Health officials referred them as “A murky wave of heart attacks” 3/…
Read 17 tweets
29 May
We know that the two Ad-vector based vaccines, #AstraZeneca & #JNJ lead to clot-related complications like cerebral venous sinus thrombosis. We also know these events are referred to as ‘Vaccine induced Thrombotic Thrombocytopenia’ (VITT). But what lead to these complications? 1/
Now a new explanation for VITT seen with vector vaccines. “Vaccine-Induced #Covid19 Mimicry” Syndrome: Splice reactions within the #SARSCoV2 Spike ORF result in ‘Spike protein variants’ that may cause thromboembolic events in patients immunized with vector-based vaccines 2/
These soluble Spike #variants may initiate severe side effects when binding to #ACE2-expressing #endothelial cells in blood vessels 3/
Read 27 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!