Discover and read the best of Twitter Threads about #VOC

Most recents (24)

#Omicron though the mildest avatar of #SARS2, but is the most transmissible VOC of the SARS2. The original WT variant had an Ro of ~2.5 & the currently dominant variant BA.2 has 12.5! So, there is marked variability in both transmissibility & severity of these VOCs. 1/
Will the next #VOC, whenever it emerges, be the mildest of all variants? A new #Scottish study concludes that it may not be the case, & severity associated with future SARS2 variants is inherently unpredictable. 2/
The principal findings of this study of the relative severity of #COVID19 cases caused by successive SARS2 variant waves in #Scotland was that, #Alpha was associated w/ more severe disease than B.1.177, #Delta was associated with more severe disease than Alpha…….3/
Read 6 tweets
They took out Qaddafi bc they needed His 400k tons of weapons so as to arm #ISIS in Syria.

Plan was to create the Muslim Refugee Crisis but it was a Trojan Horse to bring-in 100M ISIS fighters for an actual US Invasion.

Prior to this was a massive EMP attack called #LODESTAR
Obama was making trips to Cuba bc He made a deal to stage many of the ISIS Fighters in Cuba which is why he opened the Ferry Boats frm Cuba to Miami

Once the lights went out frm the #LODESTAR EMP (to be blamed on N. Korea] the invasion was to begin shortly after HRC took Office ImageImage
John McCain spilled the beans on the LODESTAR attack on America & was promptly executed for his treasonous crimes against America and the American Ppl.
Read 5 tweets
It's #SARSCoV2 #Omicron time! We have some hopefully significant findings on neutralising antibodies (nAbs) in the 70-89 age group, a group who are at high-risk from #COVID19 medrxiv.org/content/10.110…
The @vGlycoproteins team, including @pizza_regret and @The1stNazerick (joint 1st authors) have looked at neutralisation of >20 different #SARSCoV2 Spike proteins from across the globe🌏🌍🌎!

Sera is from an elderly cohort, vaccinated with Pfizer 3 weeks apart.
Getting to the last figure first, of course #Omicron. At 3 and 20-weeks post 2nd dose the nAb response to Omicron is pretty much non-existent. However, at 4 weeks post 3rd dose (aka #BoosterJab) all people had detectable neutralising antibodies, which is good news 🙏👍
Read 9 tweets
1/5
Die #COVID19-Fallzahlen gehen langsam zurück. Der Rückgang ist aber noch nicht in den Kliniken & auf den #Intensivstationen angekommen.

#RKI Präsident #Wieler in der heutigen #BPK mit Bundesgesundheitsminister @Karl_Lauterbach

BPK zum Nachschauen:
➡️ SocialCard mit folgendem Text: Gemeinsam haben wir einen lei
2/5
#Omikron ist noch ansteckender als #Delta und wird zu noch mehr Fällen führen.
Aber darauf können wir uns vorbereiten!

Informationen zu besorgniserregenden #SARSCoV2 -Varianten #VOC, inkl. Omikron
➡️rki.de/DE/Content/Inf… SocialCard mit folgendem Text: Wir müssen Kontaktbeschränk
3/5
Mit #Omikron geraten wir erneut in eine schwierige Lage. Es herrscht eine gewisse Unsicherheit, weil diese Variante neu ist & die Datenlage sehr dynamisch ist. Noch können wir einige Fragen nicht beantworten. Was wir wissen: Die #Auffrischimpfung ist sehr wichtig. SocialCard mit folgendem Text: In Deutschland sind bislang e
Read 5 tweets
Wie erfolgreich ist die Impfkampagne im #KreisAhrweiler?

✅ Es wird wieder mehr geimpft.
❌ Impfziel 85% – #Delta bewältigbar
❌ Impfziel 75% – Delta Welle schmerzhaft
❌ 65% – … katastrophal

⚠ Prognose Jahresende: 60,8% ⚠
#Covid19 #Zweitimpfungen im #KreisAhrweiler
(03.12.2021)

Alter
12-17 2396 35,90%
18-59 42917 64,58%
ab 60 32847 75,34%
Gesamt 78160 59,91%

covid.computer42.org/KreisAhrweiler…
#Covid19 #Erstimpfung im #KreisAhrweiler
(03.12.2021)

Alter
12-17 3023 45,29%
18-59 42321 63,68%
ab 60 33845 77,63%
Gesamt 79189 60,70%

covid.computer42.org/KreisAhrweiler…
Read 13 tweets
1/ #Omnikron und #Delta unter dem Blick von #ControlCovid – eine Analyse.

Was ist Control-Covid? Eine Niedrig-Inzidenz-Strategie des #RKI, welche wie andere Empfehlungen des RKI fahrlässig durch die Politik ignoriert wird.
@rki_de
2/ Niedrig-Inzidenz-Strategie heißt das die Maßnahmen so gewählt werden, das die Inzidenz in der Gesellschaft dauerhaft in einem „grünen Bereich“ bleibt.

Andere solche Strategien sind #NoCovid und #ZeroCovid.

rki.de/DE/Content/Inf…
3/ Unterschiede der Strategien sind Grenzwerte und Maßnahmenkataloge.

#ControlCovid ist im Vergleich die „schwächste“ Strategie, da die Grenzwerte vergleichsweise hoch liegen. Aber um Klassen besser als alle bisherigen Verordnungen der Politik.
Read 25 tweets
1/3:
👉🏻B.1.1.529 je tek 5. varijanta za zabrinutost (#VOC ), dodeljenog imena #OMICRON
👉🏻Deli kljucne mutacije Alfa, Beta, Gama i Delta varijanti sa dodatnim osobinama
👉🏻50 kljucnih mutacija Omikron-a: 30 u S proteinu, od cega je 15 u delu koji se vezuje za receptor (RBD)
2/3:
Pitanja na koja jos ne znamo odgovore za Omikron:
👉🏻Da li se brze prenosi?
👉🏻Da li izbegava imunski odgovor?
👉🏻Da li izaziva tezu kl.sliku?

Znamo:
❗️u J.Africi je samo 24% vakcinisanih
💉da bi adapt. vakcina, ako se sad krene sa razvojem, mogla da bude u upotrebi u leto ‘22
3/3:
🔎Prve odgovore na nepoznata pitanja imacemo za nekoliko nedelja.
🔎Sa zaustavljanjem globalnog sirenja Omikrona verovatno se vec zakasnilo.
🔎Cinjenica da je u Africi vakcinisano samo 7% stanovnistva, govori o globalnom problemu i zaristima novih varijanti.
Read 3 tweets
La #variante"Nu" B.1.1.529: segue un thread con le poche info che abbiamo. Ma non c'è da andare nel panico, ve lo spiego. Iniziamo. 1/21
#COVID19
Le autorità sudafricane sono allarmate per la rapida diffusione di una nuova #variante che in tre settimane è passata dall'1 al 30% di casi, soppiantando la #Delta (attualmente predominante nel mondo). Vediamo di cosa si tratta. 2/21
Si tratta di una variante di #SARSCoV2 emersa per la prima volta l’11 novembre 2021 a seguito di tre rilevamenti in #Botswana. 3/21
Read 21 tweets
Egal, wie gefährlich B.1.1.529 (Evtl. Ny) am Ende ist, ein paar Merksätze:

- If you need to be right before you move, you will never win
- Better safe than sorry
- Perfection is the enemy of the good
- Wenn die Zahnpasta mal aus der Tube ist, bekommen wir sie schwer wieder rein.
Zwei mögliche Fälle von #B11529 in Belgien entdeckt. Bestätigung steht noch aus.

(Via @BNODesk)

hln.be/binnenland/mog…
Read 15 tweets
What do we know about the B.1.1.529 variant of SARS-CoV-2 with a very large number of mutations
An updated thread on emerging evidence. Image
B.1.1.529 is a newly designated variant of SARS-CoV-2 github.com/cov-lineages/p…
This would not have been possible without the exemplary work of researchers in Africa who have sequenced and deposited the genomes in public domain which forms the basis of this variant designation.
The lineage (variant) is characterized by 32 conserved spike mutations A67V Δ69-70 T95I G142D/Δ143-145, Δ211/L212I ins214EPE G339D S371L S373P S375F K417N N440K G446S S477N T478K E484A Q493K G496S Q498R N501Y Y505H T547K D614G H655Y N679K P681H N764K D796Y N856K Q954H N969K L981F
Read 28 tweets
Who else knows the real story/truth about Fluoride in the water???

It has everything to do with Alcoa..

They needed to dispose of the aluminum fluoride so they started putting it in water and then later.. our food chain.

duluthreader.com/articles/2013/…
I was researching Aluminum Fluoride & then remembered some stories about Spontaneous Human Combustion & put two and two together.

Aluminum Fluoride resides in every cell at the cellular level & I believe that if a person has a "super saturation" of Aluminum Fluoride in thr body
And then that person is hit with high-powered microwaves.. they would be set on fire from the inside.

Take a piece of aluminum or better yet.. take some granular 400-mesh aluminum powder & mix it in a cup of water & place in a microwave & set for 1:00-minute.
Read 4 tweets
[Thread]
If every Government in every nation in the world is pushing for #VaccinePassports then there should NEVER be ANY doubt that they had ALL of this shit planned a long time ago.
If McConnell had allowed Merrick Garland appointment to #SCOTUS then HRC would have picked the next two so they could overturn Heller & (in a perfect world) disarm the American People!

Scalia was murdered so there would have been an open seat on the Supreme Court #ThinkAoutIt
Next.. If President Trump hadn't of won the 2016 Election then Hillary absolutely would have picked the next two so they could disarm us & we'd be just like effing New Zealand and Australia but that didn't work out.

This means they had #Covid19 planned a LONG TIME AGO!
Read 5 tweets
Muita gente ficou surpresa com as notícias referentes a C.1.2, uma variante possível aumento na transmissão e com algum escape imunológico anunciada pelo Inst. Nacional de Doenças Transmissíveis da 🇿🇦 e da Plataforma de Inov.e Seq. de Pesq. KwaZulu-Natal

Acompanha 🧶👇
RESUMO:
🔹Variante com características preocupantes, mas que não tem circulação global
🔹Nada nos diz que vacinas não abrangeriam ela
🔹Mais um indicativo de que o vírus está se adaptando
🔹A desigualdade de distr. de 💉 no 🌎 É UM PROBLEMÃO
🔹💉E 😷pelo amor de Deus

Detalhes👇
Não é segredo, nem novidade, que a permanência desse estado de transmissão elevado, que é construído por vários fatores, (baixa cobertura 💉, falta de adesão adequada a medidas como uso de 😷, p.ex), gera um risco de vermos novas variantes surgirem
Read 29 tweets
Um brilhante fio de @sailorrooscout discutindo sobre células B de memória induzidas por vacina de RNA, que continuam a aumentar em frequência pelo menos (mas não somente) por 6 meses, MESMO com a queda de anticorpos circulantes!

Acompanhe 🧶👇
Antes de tudo: @sailorrooscout com certeza é meu perfil favorito de fora do país para acompanhar a pandemia e as vacinas. Sigam esse perfil, é super tranquilo usar a ferramenta de tradução do twitter!

Thanks a lot for all your efforts @sailorrooscout ♥️
O estudo foi publicado ontem (23/08/21) na forma de preprint no @biorxivpreprint e pode ser acessado pelo link: biorxiv.org/content/10.110…
Read 34 tweets
#CoronavirusUpdate 2021/7/29🇯🇵 A physicist argues by using a brilliantly crafted animated scale to show how #StateofEmergency measures #緊急事態宣言 “cannot be used over and over again” because its effectiveness is limited without hard #lockdown measures.
#Tokyo2020 #Olympics
Dr. @ryseto updated his infographic after 3,177 cases were confirmed in Tokyo on July 28, saying "SoE declaration which can have some effect by just 'declaring" cannot be used over and over again," suggesting the declarations have not been enough.
Earlier on, he also used his infographic to show how #VoC (Variant of Concern) has been replacing the original strain of #COVID19 in #Asia. It shows a more strong measure is needed or otherwise we will be crushed by the 'apparent shift' in the equation.
Read 5 tweets
[Thread in 25: Was wir über #Delta aus #Singapur lernen können]

Vorab: Jede Menge!

Singapur hat gerade einen moderaten Ausbruch mit Delta - und ein gutes Kontakttracing, aus dem sich viele Erkenntnisse gewinnen lassen.

Zudem hat man dort eine ähnliche #Impfquote wie wir.

1/25 Image
Singapur ist mit Stand 28.06.21 praktisch der Impfdoppelgänger von Deutschland:

* 44,53% ungeimpft
* 35,51% doppelt geimpft
* dazu 19,96% einfach geimpft
* vorwiegend Impfungen mit mRNA-Impfstoffen (Moderna und BioNTech)

Das macht den Vergleich mit uns umso interessanter!

2/25
Was ist jetzt neu?

Man kann jetzt dank des #Tracing in Singapur genau zeigen, wie sich doppelt Geimpfte während eines Ausbruches mit der #Delta-Variante (#B16172) auswirken.

Zunächst das allgemeine Bild - ich drösel das in den folgenden Tweets genauer auf:

3/25 Image
Read 31 tweets
1/5 Aktualisierter #RKI-Bericht zu den #Virusvarianten (Variants of Concern #VOC, Variants of Interest #VOI) von #SARS_CoV_2:
➡️rki.de/DE/Content/Inf…

Die Darstellung basiert auf Daten aus der #Gesamtgenomsequenzierung.
2/5 Der Anteil der VOC B.1.617.2 (#Delta) nimmt weiterhin stark zu & hat sich wiederum innerhalb einer Woche verdoppelt. Diese starke Zunahme des Anteils der #Variante B.1.617.2 geht mit einer leichten Zunahme der Delta-Fallzahlen bei weiterhin abnehmender Gesamt-Inzidenz einher.
3/5 Die aktuell vorliegenden Daten zeigen, dass die #VOC Delta sich gegenüber den anderen Varianten, insbesondere auch gegenüber der bisher dominierenden Variante B.1.1.7 (#Alpha), durchsetzen wird.
Read 5 tweets
.@Genesys and @Qualtrics team up for a better experience. More accurately they are pairing G’s #CCaaS engagement data with Q’s experience data. Combines actual interaction info with voice of the customer and satisfaction scores. prnewswire.com/news-releases/… #TalkingPointzThread
The two companies have a similar vision, both have a complementary focus on customer service and experience. Genesys calls it Experience as a Service. Qualtrics calls it Experience Management. 2/9
The idea is to better understand (or map) all of the signals and data from interactions. Elements of #CCaaS #VOC and #CRM 3/9
Read 9 tweets
In the #US & #Mexico trial of #Novavax vaccine (where 50% were #Alfa variant), it shows an overall efficacy of 90.4% & 100% efficacy against moderate or severe disease, on par with the vaccines made by Pfizer-BioNTech and Moderna nytimes.com/2021/06/14/hea…
“Novavax may be used as a booster in the U.S., but it’s certainly will be the first vaccine a lot of people are going to see around the world”
#Novavax new booster vax against #Beta variant is also found highly immunogenic in #baboon studies. A strong anamnestic response was demonstrated in baboons boosted with rS-B.1.351 approximately one year after immunization with #NVXCoV2373 (rS-WU1)

biorxiv.org/content/10.110…
Read 6 tweets
After almost 6 months of global rollout of #Covid19 vaccines, we have some data to assess their comparative efficacy/effectiveness. There seems to be a gradient in their performances:
*Best performing: BNT162b2 (Israel, US & UK) & Moderna’s mRNA & Sputnik-V (Bahrain) 1/
*Moderately effective: #AstraZeneca (UK), #JNJ (US, data still evolving)
*Modestly effective: #Sinovac’s CoronaVac (Chile, Brazil, Uruguay, Middle East) #Sinopharm’s inactivated (Seychelles, Mongolia) 2/
But on safety front, the #inactivated vaccines have scored over all others, both on reactogenicity front & as far as rare, serious AEFIs are concerned 3/
Read 5 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
An introductory thread on B.1.617.2 and why we’re concerned about vaccine effectiveness (VE) against this virus. TL:DR The vaccines will work against B.1.617.2 but two doses of vaccine will be required to optimise effectiveness 1/n
The primary way of measuring likely VE (or more specifically antibody effectiveness) against a virus in the lab is the neutralisation test. In this test, we try to grow (or culture) the virus in the presence of antibodies in the laboratory 2/n
If the antibody is effective, we won’t see any growth because the virus has been ‘neutralised’. If the antibody is not effective, then we will see growth. However, it’s not a yes/no answer. There will be a range of growth from none to lots 3/n
Read 17 tweets
Logik: Die indische Mutante #Delta (#B16172) breitet sich massiv in #England aus und da sollte man erwarten, dass das #RKI sofort die unzureichende #Einreisequarantäne verbessert - aber nein - das RKI stuft die #COVID-Gefahrenlage für Deutschland herunter
Hallo Dr. #KaiSchulze, ist für das @rki_de der Ausbruch der indischen Mutante #B16172 in #England isoliert? Kann #Delta nicht durch die löchrige #Einreisequarantäne nach DE eingeschleppt werden? Wie kann man jetzt die COVID-#Risikobewertung herabstufen?
Strategie #Herdenimmunität
Todesfälle wurden offenbar einkalkuliert. #Brasilien sollte durch natürliche Infektionen zur Herdenimmunität geführt werde. Das bedeutet mit 1% IFR, 70% Herdenschwelle >1,4 Millionen einkalkulierte Todesfälle #Bolsonaro #COVIDZID nytimes.com/2021/05/27/opi…
Read 31 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets

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