very happy as we've been sending out #SIRENstudy participants at our site their spike antibody results. today i received mine, and OHHH BOOOOYYYYY are they interesting!
but first, some context 🧵
#postvac #vaccineinjuries #LongCovid #TeamClots
but first, some context 🧵
#postvac #vaccineinjuries #LongCovid #TeamClots
i will start by saying that all my nucleocapsid antibodies are unambiguously negative. each blood sample is accompanied by a PCR + another PCR in between blood samples. + a 3rd PCR a month for ONS.
the numbers. we use the Abbott IgG immunoassay which has a maximum threshold of 80,000 AU/mL. below is the information we have given to participants 
there is HUGE variation in spike antibody results to both #COVID19 and #vaccination in this cohort, though generally antibodies tend to wane quite steadily.
the median spike antibody level for ALL the spike antibody results in our dataset is ~6000 AU/mL
the median spike antibody level for ALL the spike antibody results in our dataset is ~6000 AU/mL
when dealing with participant queries, the only time I've noticed spike antibodies exceed the assay threshold of 80,000 AU/mL is when they've had 2 or 3 vaccines PLUS infection
context over, let's see my results...drum roll please...
context over, let's see my results...drum roll please...
this 👇🏻 is what happened after a single @AstraZeneca #CovidVaccine
my spike antibodies exceeded the assay threshold in less than 2 weeks, then dropped rapidly in the following weeks, followed by a plateau throughout 2022
my spike antibodies exceeded the assay threshold in less than 2 weeks, then dropped rapidly in the following weeks, followed by a plateau throughout 2022
it seems i was right, my body REALLY didn't like the spike protein
i know the cohort i work with are relatively small (~700 originally), but i've never seen such a strong response to a *single* COVID vaccine, followed by such a rapid decline
https://twitter.com/angryhacademic/status/1373653443345326083
i know the cohort i work with are relatively small (~700 originally), but i've never seen such a strong response to a *single* COVID vaccine, followed by such a rapid decline
what the hell is going on? well obviously i don't know, but some thoughts below, and of course keen to hear other ideas
idea 1: a small #LongCovid study found a bigger antibody response to vaccination predicted symptom worsening: pubmed.ncbi.nlm.nih.gov/35238053/
so i wonder if an abnormally strong response in a relatively healthy person could predict a severe chronic adverse reaction?
so i wonder if an abnormally strong response in a relatively healthy person could predict a severe chronic adverse reaction?
idea 2: why the plateau this year? if spike protein is lingering (e.g. assets.researchsquare.com/files/rs-18446…), maybe its providing a low level stimulus to keep producing antibodies?
my levels this year have fluctuated between ~70-100 AU/mL, so very small, & could just be natural variation ofc
my levels this year have fluctuated between ~70-100 AU/mL, so very small, & could just be natural variation ofc
i find this fascinating.
why does MY body react so strongly to the spike protein, when no one else's (in this cohort of several hundreds of participants) does?
This seems important to understand!
why does MY body react so strongly to the spike protein, when no one else's (in this cohort of several hundreds of participants) does?
This seems important to understand!
Other results from the same cohort, same antibody assay. Good example of just how abnormal my response was. (Ofc lots of things different here, Kev is older than me and a man being 2 key differences, but his results seem more "typical" of this cohort)
https://twitter.com/DeansKevin/status/1603451428814700577
I also wonder whether this huge peak and crash occurs frequently in those with #LongCovid and #vaccineinjuries but since patients often test their antibodies at random, we miss the acute (and potentially important) trend
• • •
Missing some Tweet in this thread? You can try to
force a refresh
