I feel like we "know" this for lots of small things
- Lasix should make 'em pee within 20 minutes
- PEEP improves oxygenation in 20 minutes
- uroseptic shock should break within 24 hour
- Lasix should make 'em pee within 20 minutes
- PEEP improves oxygenation in 20 minutes
- uroseptic shock should break within 24 hour
There are some scattered superb research projects:
- optimal durations of SBTs
- optimal time to neuroprognostication s/p anoxic injury
- Blood cultures will turn positive for MRSA w/i 48 hours if they are going to
- optimal durations of SBTs
- optimal time to neuroprognostication s/p anoxic injury
- Blood cultures will turn positive for MRSA w/i 48 hours if they are going to
(of course as I write this, I am quite dubious about the evidence base upon which most my "knowledge" rests)
Side-project: cross-site and international variation in clinician folk beliefs in time-to-response of common ICU therapies. How do folks decide when to redose?
Side-project: cross-site and international variation in clinician folk beliefs in time-to-response of common ICU therapies. How do folks decide when to redose?
But as we think about #TimeLimitedTrials, can we move beyond our experience-derived anecdotes to a more rigorous information basis?
Project 1: Time to physiologic response or (time profile of likelihood of death if no response for common treatments, purely observational
Project 1: Time to physiologic response or (time profile of likelihood of death if no response for common treatments, purely observational
Project 2: Causal inference version: during what time periods is physiologic response a valid surrogate marker of ultimate response to therapy?
Project 3: Variation in folk-beliefs and practices (actual redosing intervals)
Project 3: Variation in folk-beliefs and practices (actual redosing intervals)
