Profile picture
Antonio Regalado @antonioregalado
, 6 tweets, 2 min read Read on Twitter
"A lot of sharp problems caused fierce debates on the spot, and the smell of gunpowder was full." --from CRISPR baby maker Jiankui He's blog after attending attending Jennifer Doudna's closed-door gene-edit meeting in February 2017

blog.sciencenet.cn/blog-514529-10…
From He's blog, hanging with the CRISPR inventor in August 2016 at the CSHL meeting. blog.sciencenet.cn/home.php?mod=s…
Early on, He was interested in getting hold of some dinosaur eggs. If there were any DNA fragments inside, maybe he could sequence them.

"Who has a dinosaur egg, lend me one" blog.sciencenet.cn/blog-514529-80…
Didn't realize Jiankui He wrote a book in 2011 "Modularity: The Principle of Evolution in Complex Systems "
blog.sciencenet.cn/blog-514529-42…
I'd buy He's book, but but not for $99
Looks like the book title (and subject?) knocked off from this 2005 tome amazon.com/Modularity-Und…
Missing some Tweet in this thread?
You can try to force a refresh.

Like this thread? Get email updates or save it to PDF!

Subscribe to Antonio Regalado
Profile picture

Get real-time email alerts when new unrolls are available from this author!

This content may be removed anytime!

Twitter may remove this content at anytime, convert it as a PDF, save and print for later use!

Try unrolling a thread yourself!

how to unroll video

1) Follow Thread Reader App on Twitter so you can easily mention us!

2) Go to a Twitter thread (series of Tweets by the same owner) and mention us with a keyword "unroll" @threadreaderapp unroll

You can practice here first or read more on our help page!

More from @antonioregalado see all

Profile picture
Rogue or team player? The complex before and after reaction to He Jiankui in China.

“A milestone accomplishment China has achieved in the area of gene-editing technologies” -People's Daily, November 26th, 2018.

Since deleted from internet.

(thread)
Everyone is condemning He Jiankui right now---everyone in China saying they knew nothing about the CRISPR baby project. Yet it is more likely that many, including in government did know.
JK He had started 7 biotech companies and had millions in research grants. That's the kind of person a lot of people will know. We also know in 2017 He widely advertised his interest in making a baby to US scientists and geneticists. Seems likely he did the same in China.
Read 16 tweets
Profile picture
BREAKING: Any more babies out there? Big question at end of #geneeditsummit in HK

NEW==> Jiankui He registered a *second* study on PCSK9 (low heart disease risk)

Says only involves embryo (no transfer).but who knows.

H/t @erikwestin for inspiration

chictr.org.cn/showprojen.asp…
Let’s hear from @matthewherper about CRISPR babies versus Repatha. The baby approach will be more cost effective😝, but can’t undo ☹️
FYI, I think this trial listing discloses the prelim research on embryos both for CcR5 and pcsk9
Read 4 tweets
Profile picture
In his ethics paper, He Jiankui specifically criticized this image we published in 2015.
He complained of journalist memes of “barcoded” and “discombulated” babies.
The image was from a 2015 story we did explaining how all this was coming. technologyreview.com/s/535661/engin…
Read 5 tweets

Related threads

Profile picture
😱HOLY CRAP. A scientist in China claims to have genetically edited HEALTHY babies using #CRISPR. He Jiankui says he altered a gene in HEALTHY embryos before implanting them in the mother’s womb, with the goal of making babies resistant to HIV infection.
nytimes.com/2018/11/26/hea…
#CRISPR is a powerful gene editing tool that targets a gene to be "edited" and have its sequence changed. For several years, scientists have feared that CRISPR might be used to create "designer babies," in a new form of eugenics.😱

#crisprbabies
I can think of MULTIPLE genes that could be genetically altered to create "Super Humans" who have vastly increased strength and endurance. Forget performance enhancing drugs: if this report is true (and I have every reason to think that it is), then we've entered a whole new era.
Read 7 tweets
Profile picture
So let's comment on these reports that came out today on the creation of the first #CRISPR babies from a team at Shenzhen, China reported here -> technologyreview.com/s/612458/exclu… or here -> apnews.com/4997bb7aa36c45… and this Youtube video
What we know about it? Well not much. 1/ They have edited CCR5 gene, which prevent HIV entry. Have they edited CCR5 to generate a ∆32 mutation? no idea. It looks they edited CCR5 in the pronuclear and check editing by sequencing 3-5 days later -> 16/22 edited and 11 implanted
Twins were born with one carrying an heterozygous allele and the second baby an homozygous allele and one carried mosaic alleles. Details? No off target found but I don't have any details on this too. Are the CCR5 protein level changed? Again very little details on this.
Read 10 tweets
Profile picture
✂️🐟🎉🏀 Hey everyone, @Science_Baller here! I'll be the guest host today talking about all things #STEMed #scioutreach #scicomm and #CRISPR today! Jump with questions at any time and I'll try to answer them! It's going to be a #zebrafishparty and I'm pumped! 😎
A little about myself: I am a new lecturer in Biological Sciences @VanderbiltU . I teach a section of Introductory Bio (220 students) and 3 sections of Intro Bio Lab (16 students/each). What's the biggest course you have had to teach? #STEMed #AcademicTwitter #phdlife #phdchat
I graduated with my Ph.D. in Biochemistry in May from @RiceUniversity . My research focused on #zebrafish genetics using #CRISPR mutagenesis. My big paper discussed a new #CRISPR tool that we developed which has an increased mutation rate+longer deletions onlinelibrary.wiley.com/doi/pdf/10.100…
Read 52 tweets
Profile picture
Hace una semana lanzé un HILO en el que explicaba los orígenes e información básica para entender las herramientas #CRISPR. Gracias a @jm_alarcon ese HILO está recogido en esta web: threadreaderapp.com/thread/9834491… Hoy continuaré con otro en el que hablaré de las aplicaciones. Dentro HILO
Las herramientas #CRISPR nos han cambiado tanto la vida a los investigadores de ciencias de la vida que prácticamente suelo decir que pronto solamente habrá dos tipos de laboratorio: (1) los que YA están usando CRISPR en sus experimentos y (2) los que VAN a usar CRISPR. Y ya está
Lo que está ocurriendo con las #CRISPR y la edición genética de alguna manera recuerda a lo que ocurrió a finales de los años 80, cuando apareció y se instaló la técnica de amplificación del ADN #PCR (reacción de la polimerasa en cadena) que está presente hoy en todas partes.
Read 38 tweets
Profile picture
En apenas 5 años (los primeros experimentos que demostraban su uso como editores genéticos aparecieron en enero de 2013) las herramientas #CRISPR han revolucionado los laboratorios de todo el mundo. Voy a intentar explicar por qué, de forma resumida. Vamos con el prometido HILO:
Voy a empezar por el final. Lo que hace a las #CRISPR unas herramientas sorprendentes es su aparente facilidad para promover cambios en el genoma, en el material genético de cualquier organismo. Recordemos que el ADN está formado por cadenas de letras (nucleótidos) A, T, G y C
El ADN es una doble cadena. La A siempre se empareja con la T, y la G con la C. Cada organismo tiene un número de letras específico. Nosotros tenemos aproximadamente 3.000 millones de letras. Por el contrario una bacteria como Escherichia coli tiene apenas 3 millones de letras.
Read 38 tweets
Profile picture
Today, we are celebrating the achievements of women in science, technology, engineering & maths ow.ly/rR2u30fLxVd #AdaLovelaceDay
For #AdaLovelaceDay, we’ll be highlighting the many wonderful #womeninstem that help us understand the world today ow.ly/ehEe30fLzDU
Pratiwi Sudarmono is professor of microbiology @univ_indonesia & the first Indonesian astronaut ow.ly/Djsn30fzS5g #AdaLovelaceDay
Read 55 tweets

Trending hashtags

#organunframed #NeverAgain #BTSIsOverParty #HOSEOKLOVESYOONGI #FLYJOHNNYFLY #Cas9 #SenorBeaverotti #SNPP #NewAwarenessAwards #AI #Ronco #strangeinvitation #homersimpson #monrail #RaoulDuke #WinterSprinter #starcrawler #PhilHartman #MakeNoise #OswaldTheLuckyRabbit #STEMed #masterpiece #YoonminAU #sleeper #Naman

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just three indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member and get exclusive features!

Premium member ($30.00/year)

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!