any of you who've had me tell you "commercial melatonin supps are way overdosed", here's another reminder
you want like 0.5mg melatonin at most, 0.3 ideally; more will work no better but will desensitise your MT receptors
you want like 0.5mg melatonin at most, 0.3 ideally; more will work no better but will desensitise your MT receptors
*also* holy retweets, don't panic. As far as receptors to throw out of cal, MTNR1x are def among the least troublesome and simplest to fix
i can name this tune in ... three more tweets
i can name this tune in ... three more tweets
Receptor circuits are always in self-cal. Cal "cycle" periodicity can be as short as minutes on some to weeks on others. Some are little more than a single autoreceptor. Others? The size, extent, and sophistication of the feedback/control circuits are like nothing yet terrestrial
Jerk one out of cal, or try to target a different equilibrium point, and like any circuit it takes a few cycles to restabilize, and the different parts of it can exhibit all those fun things like ring, overshoot, etc
MTNR1x: p simple, sensitivity dominated by autoreceptor output
MTNR1x: p simple, sensitivity dominated by autoreceptor output
and, to hopefully no one's surprise, the basic periodicity of a cycle is ~24 hrs
so, if you're doing nightly 4 mg, you'll sleep fine, then be ugh/"off" (how & how much is mostly a function of how in-tune w/yourself you are) for mainly 2 or 3 days, and then it's ~cal'd for 4 mg
so, if you're doing nightly 4 mg, you'll sleep fine, then be ugh/"off" (how & how much is mostly a function of how in-tune w/yourself you are) for mainly 2 or 3 days, and then it's ~cal'd for 4 mg
Same length of time to go back, nothing broken tho. So if you're cal'd to something dumb, just take exactly none for 3 nights, no need to taper or anything. Melatonin encourages and improves sleep and sure you'll have 3 "meh" nights and days. Nbd. Then resume at a sane dosage
Minor disclaimer, MT spike at night induces some other stuff, disruption of which should not be a big deal or even that noticeable to a "normal" person. (Mostly bc their days vary so much bc suboptimal stuff that this is unlikely to be the circuit oscillating the most noticeably)
If you're worried you're sufficiently abnormal / have something unique going --> DM
I do "office hours", + endo consults by appt if it's that kind of thing, or if it's simple enough to just answer in DM of course I will. Also if it's less simple but I like you and/or the problem
I do "office hours", + endo consults by appt if it's that kind of thing, or if it's simple enough to just answer in DM of course I will. Also if it's less simple but I like you and/or the problem
Worth adding to the thread, another common "mistake" with melatonin
