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Last day of #Microbio19 and #antibioticmakers session! Chair @kate_duncan and #ECMForum CoChair @Becca_McHugh introducing the morning session and first speaker 
First speaker #antibioticsmakers #microbio19 is @NadineZiemert discussing her lab's work on novel tools and methods for #genomemining for prioritizing which biosynthetic gene clusters to follow up on for novel #bioactives #discovery
Nadine @NadineZiemert shows automated tools to find new antibiotic targets, and many other cool tools for screening genomes on antibiotic related info
Next up is @scyphs discussing his development of clusterTools for functional domain identification in biosynthetic gene clusters #ECRchat #Microbio19
Next up is Joshua Burns @RobertGordonUni @ncimb on unexplored chemical diversity of #Streptomyces for identifying novel bioactives against A. Baumannii #ECRchat #Microbio19
After the coffee break next up in #antibioticmakers #microbio19 is Wenjung Zhang from @UCBerkeley talking about her lab's work on biosynthesis of isonitrile natural products, discovery of novel pathways, and drug discovery
Zhang explains a novel carrier protein independent route to biosynthesise isontrile using the free acid, and identifies a role for the product in Mycobacterial biofilm formation and possibly copper chelation #antibioticmakers #Microbio19
Next up is Maxime Couturier from Salmond lab detailing his work on mutasynthesis for production of novel prodigiosins, creating 8 analogues in only 3 steps #ECRchat #Microbio19
Next up is @alisia_russell from @AndyTruman4 lab on genome-led discovery of novel RiPPs, ribosomally encoded peptides using the RiPPER tool #ECRchat #Microbio19
Alicia is acknowledging her lab mates, great to see a very smiley @DavidWiddick!
After lunch it is Margerita Sosio from Naicons giving industrial perspectives on natural products for the #antibioticmakers #microbio19 afternoon session
Sosio explains how Naicons employs tools for novelty evaluation and high quality screening of unexplored rare actinobacteria to identify novel natural products
Next up is @AlexJMullins from Esh lab on biopesticidal products from/using Bulkholderia ambifaria #ECRchat #Microbio19.
Next up is Asif Fazal from @ryanfseipke lab on chain termination of disparate NRPs by a trans-acting beta-lactamase, with offloading independent of TEI or TEII type offloading domains #ECRchat #Microbio19
Next up @Becca_McHugh from @PaulHoskisson lab on auredoxin, a type III secretion inhibitor from Streptomyces goldiniensis #ECRchat #Microbio19
Oops, that should have read aurodox!
Next up is Tim Walker #ECRchat @ucl on microbiome profiling and isolating strains from an ancient Roman bath water source as #niche locations that produce novel antimicrobials #Microbio19
.@timacwalker extracting compounds from agar-grown cultures, moving on to Nanopore WGS showing bioactive strain is close relative of Streptomyces canus #ECRchat #microbio19
Next up is Winifred Akwani #ECRchat showing her PhD work at @UniOfSurrey on drug penetration in non-tb Mycobacterial biofilms using Nano-SIMS #MicroBio19
Next up @r_devine93 from @MattHutchings10 lab on novel 🐜biotics from #Streptomyces formicae, an isolate from fungus-farming ants from acacia #ECRchat #Microbio19
.@r_devine93 has unleashed #CRISPR Cas on S.formica to find different potent bioactive compounds, seeing different chemistries linking to activities #ECRchat #Microbio19
Penultimate offered paper by @BlessAnonye from @friendlymicrobe lab on the potential of an Anglo-Saxon remedy for treating diabetic foot ulcers using an artificial wound infection model #ECRchat #Microbio19
Final #ECRchat speaker of a most interesting #antibioticsmakers #Microbio19 session is @flwrs4algrnon, delivered by @Hairy_Llama, on in silico predicting and prioritizing antimicrobial peptides using the AMPLY platform
Mixing art and science: @flwrs4algrnon used poetry lines from medieval Welsh poetry Book of Taliesin as amino acid peptide input into AMPLY identifying Savage Dawn peptides with real antimicrobials with good MICs
Taliecin-1 is the first legitimate amphipathic AMP created from Welsh!
And that's a wrap! Thank you @MicrobioSoc for a fab #microbio19 Annual Conference! Bring on #microbio20 in Edinburgh!
*please read 'with' as 'that act as'
Seen this/were you involved in this study @di_luft ?
