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B. Wagner, M.D.
@Wagner_Nephro
, 11 tweets, 16 min read Read on Twitter
“Gadolinium-based contrast agents: Stimulators of myeloid-induced renal fibrosis and major metabolic disruptors,“ is now in press—sciencedirect.com/science/articl…

#gadolinium
#neurology 🧠
#radiology ☢️
#patientsafety
#publichealth
#toxicology
#dermatology
#nephrology
“Gadolinium-based contrast agents are not biologically inert,” sciencedirect.com/science/articl…

#gadolinium
#neurology 🧠
#radiology ☢️
#patientsafety
#publichealth
#toxicology
#dermatology
#nephrology
#rheumatology
Gadolinium-based “magnetic resonance imaging contrast agent treatment impaired renal function, induced pathologic damage, and increased kidney fibrosis,” sciencedirect.com/science/articl…

#gadolinium
#nephrology
#radiology ☢️
#patientsafety
#publichealth
#toxicology
“Mesh-like, electron-dense, gadolinium-rich nanostructures form in the renal glomerulus and proximal tubule as a result of magnetic resonance imaging contrast agent administration,” sciencedirect.com/science/articl…

#gadolinium
#radiology ☢️
#patientsafety
#toxicology
#nephrology
Gadolinium-based contrast agent-induced “subcellular violence results in recruitment of myeloid-derived fibrocytes and dysregulation of cellular energy production,” sciencedirect.com/science/articl…

#gadolinium
#radiology ☢️
#patientsafety
#publichealth
#toxicology
#nephrology
“Gadolinium-based contrast agent treatment induces dyslipidemia (elevated total cholesterol, elevated triglycerides) and induces insulin resistance,” sciencedirect.com/science/articl…

#gadolinium
#radiology ☢️
#patientsafety
#publichealth
#toxicology
#dermatology
#nephrology
“[A]nalogous to high fat diet-induced obesity, gadolinium-based contrast agents promote accumulation of lipid-laden deposits in the kidney,” sciencedirect.com/science/articl…

#gadolinium
#radiology ☢️
#patientsafety
#publichealth
#toxicology
#nephrology
“Histologic damage induced by gadolinium-based contrast agent treatment and experimental obesity are similar (and additive),” sciencedirect.com/science/articl…

#gadolinium
#radiology ☢️
#patientsafety
#publichealth
#toxicology
#nephrology
High fat diet “and gadolinium-based contrast agent treatment disrupt cellular metabolism in similar manners (with respect to disrupted oxidative phosphorylation, glycolytic switching, and perturbation of the tricarboxylic acid cycle),” sciencedirect.com/science/articl…

#gadolinium
“Despite low systemic concentrations, gadolinium from magnetic resonance imaging contrast is retained and aggregates in the lysosomes of vital organs, such as the kidneys,” sciencedirect.com/science/articl…

#gadolinium
#radiology
#patientsafety
#publichealth
#toxicology
#nephrology
“[S]imilar to how lanthanum cations leach phosphorous from cellular membranes—[gadolinium-based contrast agent administration] induces the disruption of normal cellular metabolism that culminates in the initiation of fibrosis,” sciencedirect.com/science/articl…

#gadolinium
#radiology ☢️
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Related hashtags

#gadolinium #neurology #radiology #patientsafety #publichealth #toxicology #dermatology #nephrology #rheumatology

More from @Wagner_Nephro see all

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B. Wagner, M.D.
@Wagner_Nephro
“[I]t is known that during those at least 6 weeks [after exposure to gadolinium-based contrast agent] equilibrium has not been reached and [gadolinium] can be measured for all [gadolinium-based contrast agents] in tissue,” fda.gov/downloads/Advi…

#gadolinium
🧠
☢️
“It is important to note that the exact mechanism and in particular other co-factors that are likely needed to trigger [‘nephrogenic’ systemic fibrosis] are still unknown,” fda.gov/downloads/Advi…

#gadolinium
#neurology 🧠
#radiology ☢️
#patientsafety
#publichealth
“[T]he levels of gadolinium in the body considered normal in the absence of any [gadolinium-based contrast agent] exposure is, for practical purposes, zero,” fda.gov/downloads/Advi…

#gadolinium
#neurology 🧠
#radiology ☢️
#patientsafety
#publichealth
#toxicology
Read 4 tweets
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B. Wagner, M.D.
@Wagner_Nephro
“Gadolinium is a rare earth element. It is a toxic heavy metal,” foodphoenix.blogspot.com/2019/04/litera…

#gadolinium
#neurology 🧠
#radiology ☢️
#patientsafety
#publichealth
#toxicology
#dermatology
#nephrology
#rheumatology
“Notably, in recently published rodent studies, complete clearance of the brain took up to 6 months after injection of a large amount of” gadolinium-based contrast agents. journals.lww.com/investigativer… @HrsQuiet
#gadolinium
#neurology 🧠
#radiology ☢️
#patientsafety
#publichealth
“[S]o it can be assumed that the total clearance—if achieved at all—might also take months in humans,” after gadolinium-based contrast administration— journals.lww.com/investigativer… @HrsQuiet
#gadolinium
#neurology 🧠
#radiology ☢️
#patientsafety
#publichealth
#toxicology
Read 4 tweets
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B. Wagner, M.D.
@Wagner_Nephro
“A conspicuous knowledge gap now exists about” the safety of gadolinium-based contrast agents—Dr. Stephen Brown, Harvard Medical School, in
The Need for National Guidance Around Informed Consent About GBCA Safety
tandfonline.com/doi/abs/10.108…
#gadolinium #radiology #patientsafety
“The research protocol under discussion highlights where the [National Institutes of Health] Roadmap around [gadolinium-based contrast agents] falls short,” because informed consent about gadolinium deposition could be left out—Dr. Stephen Brown
tandfonline.com/doi/abs/10.108…
“The [Institutional Review Board] should first clarify that gadolinium deposition is NOT INCIDENTAL in this study,” [emphasis added]—Dr. Stephen Brown, Harvard Medical School, in
The Need for National Guidance Around Informed Consent About GBCA Safety
tandfonline.com/doi/abs/10.108…
Read 7 tweets

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Dr Mark Guthridge
@Dr_M_Guthridge
Thread:

The 10 publications below provide scientific evidence that patients with #MECFS have #brain abnormalities in #neuroinflammation, #metabolism, #neurological connections and blood perfusion

#pwME suffer from #chronicillness

#pwME are #SickNotWeak
1. These studies “provide evidence of #neuroinflammation in #MECFS.. as well as evidence of the possible contribution of neuroinflammation to the pathophysiology of #MECFS”

#pwME

jnm.snmjournals.org/content/55/6/9…
2. This Australian study found abnormalities in the #brain MRIs and peripheral Blood Pressure and Heart Rate in #MECFS patients including the Vasomotor centre, midbrain and hypothalamus

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sciencedirect.com/science/articl…
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Caroline O.
@RVAwonk
Now seems like a good to repeat my regularly scheduled warning about the dangers of conspiracy theories and conspiratorial logic. So let's talk about that, and why conspiracy theories are particularly dangerous when combined with the politics of fear. ...1/
Critical context for this discussion: Robert Bowers, the suspect in the Pittsburgh synagogue shooting, was reportedly inspired in part by a conspiracy theory (peddled by right-wing media, pundits, & politicians) about Jews funding the migrant "caravan." 2/
This conspiracy theory has been around for a while. In April, Big League Politics (a right-wing website founded by former Breitbart employees) ran a piece falsely claiming that Soros-sponsored groups are funding the migrant "caravan." Fringe right-wing sites ran with it. 3/
Read 21 tweets
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Maarten van Smeden
@MaartenvSmeden
Let's try something new: *7 days, 7 statistical misconceptions*.
Over the next 7 days I'll post about 1 statistical misconception a day. Curious to hear your favorite #statsmisconceptions, so feel free to add you own to this thread
Day 1: "Sample size has nothing to do with bias"
👆 is something I still hear regularly. This misconception seems to be based on the oversimplified idea that sample size only affects precision - something I was told repeatedly in the first years of my studies
Read 93 tweets
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Bob Berwyn
@bberwyn
mountains, snow, avalanches and climate at #ISSW2018
Now sitting in on a session with @oeav on excessive ski area development in Tirol.
Lots of ski areas in Tirol, more lifts planned as resorts try to outrace #globalwarming. But it’s too much, says @oeav - seele-der-alpen.at
Read 51 tweets
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Jennifer Brea
@jenbrea
I don't know who wrote this but this is absolutely false and deeply embarrassing for @SMC_London: sciencemediacentre.org/cfsme-the-illn… which has shown again and again that it has absolutely no respect for science and is willing to mislead the media by promoting pseudoscience.
First, on the idea that is is somehow a battle between the medical community and "campaigners..."
.@owasow and I were hanging out with friends last weekend, one of whom happens to be a social psychology professor. We were discussing the the replication crisis in her field and completely unprompted she brought up the PACE Trial. @SMC_London
Read 40 tweets

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