Thread by @nick_krontiris

Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis

doi.org/10.1007/s00394…

#nutrition #VitaminK #CVD #CHD

- "Our results suggested that higher dietary phylloquinone and menaquinone intakes were consistently associated with a lower risk of total CHD, and higher dp-ucMGP concentration was associated with a higher risk of all-cause and CVD mortality...

"...In general, these data support potential benefts of vitamin K on the prevention of CVD events and all-cause mortality"

- "we found that higher dietary intakes of phylloquinone and menaquinone intake were associated with a lower risk of total CHD and a trend of lower risk but not statistically signifcant association with fatal CHD. The association appeared to be stronger for menaquinone...

"...the associations between menaquinone and CHD risks were unlikely due to confounding by a healthier diet, since menaquinone is primarily derived from dairy products, meat, and eggs, and the associations between those food groups and CHD risks were not entirely consistent...

"...no signifcant association was found for dairy

doi.org/10.1007/s10654…

and egg,

doi.org/10.1136/bmj.e8…

while increased risk was found for meat,

doi.org/10.1080/104083…

particularly processed red meat...

"...Therefore, the inverse association between menaquinone and CHD risks cannot be explained by the food sources"

- "plasma dp-ucMGP concentration is an objective biomarker that may refect vitamin K status and can avoid the aforesaid measurement errors... Although circulating total osteocalcin is thought to be a sensitive marker to reflect vitamin K status...

"...we did not find any signifcant associations between total osteocalcin and all-cause mortality or total CVD...

"...It is possible that dp-ucMGP is the main vitamin K status indicator of vascular calcifcation, while total osteocalcin is related to bone formation

doi.org/10.1007/s13668…"